![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PHYHIPL |
Gene summary for PHYHIPL |
![]() |
Gene information | Species | Human | Gene symbol | PHYHIPL | Gene ID | 84457 |
Gene name | phytanoyl-CoA 2-hydroxylase interacting protein like | |
Gene Alias | PHYHIPL | |
Cytomap | 10q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96FC7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84457 | PHYHIPL | HCC1_Meng | Human | Liver | HCC | 1.51e-06 | -3.29e-02 | 0.0246 |
84457 | PHYHIPL | HCC1 | Human | Liver | HCC | 7.94e-12 | 4.86e+00 | 0.5336 |
84457 | PHYHIPL | HCC2 | Human | Liver | HCC | 6.16e-09 | 2.40e+00 | 0.5341 |
84457 | PHYHIPL | S014 | Human | Liver | HCC | 2.27e-40 | 1.27e+00 | 0.2254 |
84457 | PHYHIPL | S015 | Human | Liver | HCC | 5.31e-32 | 1.56e+00 | 0.2375 |
84457 | PHYHIPL | S016 | Human | Liver | HCC | 2.72e-47 | 1.58e+00 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHYHIPL | insertion | Nonsense_Mutation | novel | c.806_807insCTTGGGTTAAAAAGCCAAAACAAGGGCTGA | p.Gly269_Asp270insLeuGlyTerLysAlaLysThrArgAlaGlu | p.G269_D270insLG*KAKTRAE | Q96FC7 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PHYHIPL | deletion | In_Frame_Del | c.270_281delAGAGAACAAGAA | p.Lys90_Lys93del | p.K90_K93del | Q96FC7 | protein_coding | TCGA-E2-A154-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |||
PHYHIPL | SNV | Missense_Mutation | rs369674396 | c.766G>A | p.Ala256Thr | p.A256T | Q96FC7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PHYHIPL | SNV | Missense_Mutation | c.914N>A | p.Ser305Tyr | p.S305Y | Q96FC7 | protein_coding | tolerated(0.14) | benign(0.036) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHYHIPL | SNV | Missense_Mutation | c.349A>G | p.Thr117Ala | p.T117A | Q96FC7 | protein_coding | tolerated(0.16) | benign(0.129) | TCGA-AA-A01Z-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHYHIPL | SNV | Missense_Mutation | novel | c.670N>C | p.Lys224Gln | p.K224Q | Q96FC7 | protein_coding | tolerated(0.19) | possibly_damaging(0.548) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PHYHIPL | SNV | Missense_Mutation | c.635N>G | p.Asp212Gly | p.D212G | Q96FC7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-3885-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
PHYHIPL | SNV | Missense_Mutation | c.1019T>G | p.Leu340Arg | p.L340R | Q96FC7 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHYHIPL | SNV | Missense_Mutation | novel | c.279N>T | p.Lys93Asn | p.K93N | Q96FC7 | protein_coding | tolerated(0.16) | benign(0.32) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PHYHIPL | deletion | Frame_Shift_Del | novel | c.375delN | p.Pro126GlnfsTer7 | p.P126Qfs*7 | Q96FC7 | protein_coding | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |