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Gene: PHGR1 |
Gene summary for PHGR1 |
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Gene information | Species | Human | Gene symbol | PHGR1 | Gene ID | 644844 |
Gene name | proline, histidine and glycine rich 1 | |
Gene Alias | PHGR1 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A1L2EC20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
644844 | PHGR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.70e-29 | 3.05e+00 | -0.1808 |
644844 | PHGR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.83e-15 | 1.18e+00 | -0.0811 |
644844 | PHGR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.97e-05 | 9.32e-01 | -0.1088 |
644844 | PHGR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.15e-48 | 2.42e+00 | -0.1954 |
644844 | PHGR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.63e-13 | 3.27e+00 | -0.2602 |
644844 | PHGR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.41e-16 | 2.89e+00 | -0.2196 |
644844 | PHGR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.76e-38 | 2.59e+00 | -0.1207 |
644844 | PHGR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.53e-15 | 2.16e+00 | -0.1526 |
644844 | PHGR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.50e-27 | 2.51e+00 | -0.1464 |
644844 | PHGR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.79e-14 | 1.35e+00 | -0.1001 |
644844 | PHGR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.68e-17 | 2.10e+00 | -0.059 |
644844 | PHGR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.48e-23 | 2.95e+00 | -0.1706 |
644844 | PHGR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.10e-22 | 2.37e+00 | -0.2061 |
644844 | PHGR1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.72e-12 | 2.69e+00 | -0.1462 |
644844 | PHGR1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.56e-19 | 1.99e+00 | -0.0842 |
644844 | PHGR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.58e-06 | 9.38e-01 | -0.0177 |
644844 | PHGR1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.55e-02 | 7.72e-01 | 0.0171 |
644844 | PHGR1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.22e-02 | 5.42e-01 | 0.0338 |
644844 | PHGR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.57e-04 | 6.20e-01 | 0.0674 |
644844 | PHGR1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.95e-02 | 4.16e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHGR1 | SNV | Missense_Mutation | novel | c.101N>T | p.Pro34Leu | p.P34L | C9JFL3 | protein_coding | benign(0.067) | TCGA-DD-AAVY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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