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Gene: PHF17 |
Gene summary for PHF17 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PHF17 | Gene ID | 79960 |
Gene name | jade family PHD finger 1 | |
Gene Alias | PHF17 | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q6IE81 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79960 | PHF17 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 1.55e-02 | 4.07e-01 | 0.1479 |
79960 | PHF17 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 1.29e-04 | 5.68e-01 | 0.1531 |
79960 | PHF17 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 6.73e-22 | 6.93e-01 | 0.1633 |
79960 | PHF17 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.78e-12 | 4.31e-01 | 0.1608 |
79960 | PHF17 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 4.78e-16 | 5.80e-01 | 0.1604 |
79960 | PHF17 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 2.44e-23 | 7.34e-01 | 0.1621 |
79960 | PHF17 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 1.83e-09 | 7.14e-01 | 0.1619 |
79960 | PHF17 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.86e-05 | 4.26e-01 | 0.159 |
79960 | PHF17 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.61e-11 | 5.46e-01 | 0.1602 |
79960 | PHF17 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 2.14e-14 | 8.21e-01 | 0.1608 |
79960 | PHF17 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 4.97e-13 | 8.10e-01 | 0.1622 |
79960 | PHF17 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 3.09e-16 | 5.79e-01 | 0.1575 |
79960 | PHF17 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 8.22e-09 | 4.23e-01 | 0.1545 |
79960 | PHF17 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.53e-12 | 5.81e-01 | 0.1569 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Prostate | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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