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Gene: PHF14 |
Gene summary for PHF14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PHF14 | Gene ID | 9678 |
| Gene name | PHD finger protein 14 | |
| Gene Alias | PHF14 | |
| Cytomap | 7p21.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DG57 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9678 | PHF14 | CA_HPV_1 | Human | Cervix | CC | 9.97e-04 | -1.68e-01 | 0.0264 |
| 9678 | PHF14 | CA_HPV_3 | Human | Cervix | CC | 1.34e-02 | 1.94e-01 | 0.0414 |
| 9678 | PHF14 | CCI_1 | Human | Cervix | CC | 1.77e-03 | 6.78e-01 | 0.528 |
| 9678 | PHF14 | CCI_3 | Human | Cervix | CC | 8.06e-03 | 5.61e-01 | 0.516 |
| 9678 | PHF14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.08e-13 | -4.80e-01 | 0.0155 |
| 9678 | PHF14 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.96e-04 | -4.76e-01 | -0.1207 |
| 9678 | PHF14 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.91e-06 | -2.88e-01 | -0.1464 |
| 9678 | PHF14 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.23e-02 | -2.77e-01 | -0.1001 |
| 9678 | PHF14 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.97e-05 | -5.89e-01 | -0.2061 |
| 9678 | PHF14 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.60e-06 | 9.75e-01 | 0.3487 |
| 9678 | PHF14 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.94e-03 | 5.24e-01 | 0.281 |
| 9678 | PHF14 | A002-C-010 | Human | Colorectum | FAP | 1.94e-02 | 1.71e-01 | 0.242 |
| 9678 | PHF14 | A015-C-203 | Human | Colorectum | FAP | 1.61e-27 | -2.16e-01 | -0.1294 |
| 9678 | PHF14 | A015-C-204 | Human | Colorectum | FAP | 4.66e-04 | -9.87e-02 | -0.0228 |
| 9678 | PHF14 | A014-C-040 | Human | Colorectum | FAP | 9.56e-07 | -1.53e-01 | -0.1184 |
| 9678 | PHF14 | A002-C-201 | Human | Colorectum | FAP | 4.81e-12 | -1.59e-01 | 0.0324 |
| 9678 | PHF14 | A002-C-203 | Human | Colorectum | FAP | 1.65e-03 | 1.77e-01 | 0.2786 |
| 9678 | PHF14 | A001-C-119 | Human | Colorectum | FAP | 2.55e-04 | 2.11e-02 | -0.1557 |
| 9678 | PHF14 | A001-C-108 | Human | Colorectum | FAP | 6.85e-11 | -5.98e-02 | -0.0272 |
| 9678 | PHF14 | A002-C-205 | Human | Colorectum | FAP | 4.16e-27 | 1.44e-02 | -0.1236 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
| GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
| GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
| GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
| GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
| GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
| GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
| GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
| GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
| GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
| GO:00064755 | Esophagus | HGIN | internal protein amino acid acetylation | 36/2587 | 160/18723 | 1.87e-03 | 2.01e-02 | 36 |
| GO:00183935 | Esophagus | HGIN | internal peptidyl-lysine acetylation | 35/2587 | 158/18723 | 2.82e-03 | 2.75e-02 | 35 |
| GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
| GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
| GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
| GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
| GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
| GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
| GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
| GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PHF14 | SNV | Missense_Mutation | c.1852N>T | p.Asp618Tyr | p.D618Y | O94880 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
| PHF14 | SNV | Missense_Mutation | rs751491414 | c.2396N>A | p.Arg799Gln | p.R799Q | O94880 | protein_coding | deleterious(0) | possibly_damaging(0.744) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| PHF14 | SNV | Missense_Mutation | c.2483N>C | p.Arg828Thr | p.R828T | O94880 | protein_coding | deleterious(0.04) | benign(0.074) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| PHF14 | SNV | Missense_Mutation | rs753298294 | c.2027G>A | p.Arg676Gln | p.R676Q | O94880 | protein_coding | tolerated(0.18) | benign(0.14) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PHF14 | SNV | Missense_Mutation | rs751823773 | c.2534N>G | p.Glu845Gly | p.E845G | O94880 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
| PHF14 | SNV | Missense_Mutation | c.921G>C | p.Lys307Asn | p.K307N | O94880 | protein_coding | tolerated(0.06) | benign(0.143) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| PHF14 | deletion | Frame_Shift_Del | novel | c.1226delN | p.Leu410CysfsTer6 | p.L410Cfs*6 | O94880 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| PHF14 | SNV | Missense_Mutation | novel | c.2275C>T | p.Leu759Phe | p.L759F | O94880 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
| PHF14 | SNV | Missense_Mutation | c.877N>A | p.Leu293Ile | p.L293I | O94880 | protein_coding | tolerated(0.11) | benign(0.045) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| PHF14 | SNV | Missense_Mutation | c.1154N>A | p.Cys385Tyr | p.C385Y | O94880 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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