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Gene: PHF13 |
Gene summary for PHF13 |
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Gene information | Species | Human | Gene symbol | PHF13 | Gene ID | 148479 |
Gene name | PHD finger protein 13 | |
Gene Alias | PHF5 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A158RFV6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148479 | PHF13 | LZE24T | Human | Esophagus | ESCC | 2.29e-07 | 1.58e-01 | 0.0596 |
148479 | PHF13 | P1T-E | Human | Esophagus | ESCC | 2.94e-04 | 2.31e-01 | 0.0875 |
148479 | PHF13 | P2T-E | Human | Esophagus | ESCC | 3.19e-20 | 3.25e-01 | 0.1177 |
148479 | PHF13 | P4T-E | Human | Esophagus | ESCC | 2.21e-11 | 1.20e-01 | 0.1323 |
148479 | PHF13 | P5T-E | Human | Esophagus | ESCC | 2.13e-08 | 7.85e-02 | 0.1327 |
148479 | PHF13 | P8T-E | Human | Esophagus | ESCC | 8.14e-08 | 4.93e-02 | 0.0889 |
148479 | PHF13 | P9T-E | Human | Esophagus | ESCC | 1.43e-04 | 5.48e-02 | 0.1131 |
148479 | PHF13 | P10T-E | Human | Esophagus | ESCC | 3.41e-09 | 7.14e-02 | 0.116 |
148479 | PHF13 | P11T-E | Human | Esophagus | ESCC | 5.70e-03 | 1.32e-01 | 0.1426 |
148479 | PHF13 | P12T-E | Human | Esophagus | ESCC | 6.23e-14 | 2.86e-01 | 0.1122 |
148479 | PHF13 | P15T-E | Human | Esophagus | ESCC | 3.24e-09 | 1.97e-01 | 0.1149 |
148479 | PHF13 | P16T-E | Human | Esophagus | ESCC | 1.84e-07 | 1.55e-01 | 0.1153 |
148479 | PHF13 | P17T-E | Human | Esophagus | ESCC | 2.40e-02 | 1.20e-01 | 0.1278 |
148479 | PHF13 | P20T-E | Human | Esophagus | ESCC | 4.71e-16 | 1.39e-01 | 0.1124 |
148479 | PHF13 | P21T-E | Human | Esophagus | ESCC | 2.15e-09 | 1.15e-01 | 0.1617 |
148479 | PHF13 | P22T-E | Human | Esophagus | ESCC | 7.98e-04 | -2.75e-02 | 0.1236 |
148479 | PHF13 | P23T-E | Human | Esophagus | ESCC | 1.48e-08 | 1.83e-01 | 0.108 |
148479 | PHF13 | P24T-E | Human | Esophagus | ESCC | 5.55e-11 | 7.04e-02 | 0.1287 |
148479 | PHF13 | P26T-E | Human | Esophagus | ESCC | 5.41e-19 | 2.37e-01 | 0.1276 |
148479 | PHF13 | P27T-E | Human | Esophagus | ESCC | 7.64e-16 | 4.09e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00070761 | Esophagus | ESCC | mitotic chromosome condensation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF13 | SNV | Missense_Mutation | c.59A>C | p.Lys20Thr | p.K20T | Q86YI8 | protein_coding | deleterious(0.01) | benign(0.154) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
PHF13 | SNV | Missense_Mutation | c.760A>C | p.Thr254Pro | p.T254P | Q86YI8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PHF13 | SNV | Missense_Mutation | novel | c.682G>A | p.Asp228Asn | p.D228N | Q86YI8 | protein_coding | deleterious(0) | possibly_damaging(0.766) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHF13 | SNV | Missense_Mutation | c.490N>T | p.Pro164Ser | p.P164S | Q86YI8 | protein_coding | tolerated(0.58) | benign(0) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PHF13 | SNV | Missense_Mutation | c.769C>T | p.His257Tyr | p.H257Y | Q86YI8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PHF13 | SNV | Missense_Mutation | c.830N>A | p.Cys277Tyr | p.C277Y | Q86YI8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHF13 | SNV | Missense_Mutation | rs182208081 | c.458N>T | p.Thr153Met | p.T153M | Q86YI8 | protein_coding | tolerated(0.36) | benign(0.006) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHF13 | SNV | Missense_Mutation | rs141668960 | c.202G>A | p.Asp68Asn | p.D68N | Q86YI8 | protein_coding | deleterious(0.05) | possibly_damaging(0.734) | TCGA-AZ-4308-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Targeted Molecular therapy | avastin | CR |
PHF13 | SNV | Missense_Mutation | c.697N>A | p.Val233Met | p.V233M | Q86YI8 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PHF13 | SNV | Missense_Mutation | rs138938066 | c.65N>A | p.Arg22His | p.R22H | Q86YI8 | protein_coding | tolerated(0.07) | benign(0.019) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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