GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701516 | Endometrium | AEH | actin filament organization | 98/2100 | 442/18723 | 1.99e-11 | 2.98e-09 | 98 |
GO:00315329 | Endometrium | AEH | actin cytoskeleton reorganization | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:003103210 | Endometrium | AEH | actomyosin structure organization | 46/2100 | 196/18723 | 8.00e-07 | 2.91e-05 | 46 |
GO:005101716 | Endometrium | AEH | actin filament bundle assembly | 39/2100 | 157/18723 | 1.21e-06 | 3.91e-05 | 39 |
GO:006157216 | Endometrium | AEH | actin filament bundle organization | 39/2100 | 161/18723 | 2.36e-06 | 6.86e-05 | 39 |
GO:003003815 | Endometrium | AEH | contractile actin filament bundle assembly | 28/2100 | 106/18723 | 1.08e-05 | 2.45e-04 | 28 |
GO:004314915 | Endometrium | AEH | stress fiber assembly | 28/2100 | 106/18723 | 1.08e-05 | 2.45e-04 | 28 |
GO:00163588 | Endometrium | AEH | dendrite development | 46/2100 | 243/18723 | 2.56e-04 | 3.03e-03 | 46 |
GO:00017642 | Endometrium | AEH | neuron migration | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:000701517 | Endometrium | EEC | actin filament organization | 95/2168 | 442/18723 | 1.31e-09 | 1.09e-07 | 95 |
GO:003153214 | Endometrium | EEC | actin cytoskeleton reorganization | 33/2168 | 107/18723 | 7.46e-08 | 3.89e-06 | 33 |
GO:003103214 | Endometrium | EEC | actomyosin structure organization | 46/2168 | 196/18723 | 1.94e-06 | 5.80e-05 | 46 |
GO:005101717 | Endometrium | EEC | actin filament bundle assembly | 37/2168 | 157/18723 | 1.71e-05 | 3.26e-04 | 37 |
GO:006157217 | Endometrium | EEC | actin filament bundle organization | 37/2168 | 161/18723 | 3.09e-05 | 5.34e-04 | 37 |
GO:003003816 | Endometrium | EEC | contractile actin filament bundle assembly | 27/2168 | 106/18723 | 5.47e-05 | 8.64e-04 | 27 |
GO:004314916 | Endometrium | EEC | stress fiber assembly | 27/2168 | 106/18723 | 5.47e-05 | 8.64e-04 | 27 |
GO:00017641 | Endometrium | EEC | neuron migration | 33/2168 | 156/18723 | 4.17e-04 | 4.38e-03 | 33 |
GO:001635813 | Endometrium | EEC | dendrite development | 44/2168 | 243/18723 | 1.72e-03 | 1.34e-02 | 44 |
GO:00219874 | Endometrium | EEC | cerebral cortex development | 23/2168 | 114/18723 | 5.41e-03 | 3.32e-02 | 23 |
GO:00070158 | Lung | IAC | actin filament organization | 92/2061 | 442/18723 | 1.01e-09 | 1.93e-07 | 92 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHACTR1 | SNV | Missense_Mutation | rs749322966 | c.323G>A | p.Arg108His | p.R108H | Q9C0D0 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHACTR1 | SNV | Missense_Mutation | | c.217N>A | p.Ala73Thr | p.A73T | Q9C0D0 | protein_coding | tolerated(1) | benign(0.013) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHACTR1 | SNV | Missense_Mutation | rs867956571 | c.1736G>A | p.Arg579Gln | p.R579Q | Q9C0D0 | protein_coding | deleterious(0.01) | benign(0.294) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHACTR1 | SNV | Missense_Mutation | novel | c.1736N>T | p.Arg579Leu | p.R579L | Q9C0D0 | protein_coding | deleterious(0) | benign(0.302) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHACTR1 | SNV | Missense_Mutation | novel | c.116C>T | p.Thr39Ile | p.T39I | Q9C0D0 | protein_coding | deleterious_low_confidence(0.01) | benign(0.118) | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
PHACTR1 | SNV | Missense_Mutation | rs751014962 | c.1732N>T | p.His578Tyr | p.H578Y | Q9C0D0 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHACTR1 | SNV | Missense_Mutation | | c.1681N>G | p.Lys561Glu | p.K561E | Q9C0D0 | protein_coding | deleterious(0) | possibly_damaging(0.81) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
PHACTR1 | SNV | Missense_Mutation | | c.1531G>A | p.Glu511Lys | p.E511K | Q9C0D0 | protein_coding | deleterious(0.02) | probably_damaging(0.952) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PHACTR1 | SNV | Missense_Mutation | novel | c.983N>T | p.Glu328Val | p.E328V | Q9C0D0 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PHACTR1 | deletion | In_Frame_Del | | c.1250_1252delNNN | p.Lys417_Val418delinsIle | p.K417_V418delinsI | Q9C0D0 | protein_coding | | | TCGA-A2-A0SV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate therapy | zometa | PD |