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Gene: PGPEP1 |
Gene summary for PGPEP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PGPEP1 | Gene ID | 54858 |
Gene name | pyroglutamyl-peptidase I | |
Gene Alias | PAP-I | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NXJ5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54858 | PGPEP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.90e-05 | 4.37e-01 | -0.1808 |
54858 | PGPEP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.00e-06 | 4.13e-01 | -0.0811 |
54858 | PGPEP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.72e-11 | 4.54e-01 | -0.1954 |
54858 | PGPEP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.34e-03 | 9.01e-01 | -0.2602 |
54858 | PGPEP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-03 | 4.50e-01 | -0.1464 |
54858 | PGPEP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.17e-02 | 4.03e-01 | -0.059 |
54858 | PGPEP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.75e-02 | 3.28e-01 | 0.0674 |
54858 | PGPEP1 | A002-C-010 | Human | Colorectum | FAP | 5.60e-04 | -1.80e-01 | 0.242 |
54858 | PGPEP1 | A015-C-203 | Human | Colorectum | FAP | 4.82e-09 | -2.03e-01 | -0.1294 |
54858 | PGPEP1 | A001-C-108 | Human | Colorectum | FAP | 1.40e-06 | -1.54e-01 | -0.0272 |
54858 | PGPEP1 | A002-C-205 | Human | Colorectum | FAP | 3.77e-05 | -1.89e-01 | -0.1236 |
54858 | PGPEP1 | A015-C-006 | Human | Colorectum | FAP | 2.98e-03 | -2.57e-01 | -0.0994 |
54858 | PGPEP1 | A015-C-106 | Human | Colorectum | FAP | 3.26e-05 | -1.53e-01 | -0.0511 |
54858 | PGPEP1 | A002-C-114 | Human | Colorectum | FAP | 4.93e-05 | -2.49e-01 | -0.1561 |
54858 | PGPEP1 | A015-C-104 | Human | Colorectum | FAP | 1.24e-11 | -2.22e-01 | -0.1899 |
54858 | PGPEP1 | A001-C-014 | Human | Colorectum | FAP | 5.30e-05 | -1.54e-01 | 0.0135 |
54858 | PGPEP1 | A002-C-016 | Human | Colorectum | FAP | 2.34e-08 | -2.15e-01 | 0.0521 |
54858 | PGPEP1 | A001-C-203 | Human | Colorectum | FAP | 1.80e-05 | -8.66e-02 | -0.0481 |
54858 | PGPEP1 | A002-C-116 | Human | Colorectum | FAP | 6.93e-10 | -1.78e-01 | -0.0452 |
54858 | PGPEP1 | A014-C-008 | Human | Colorectum | FAP | 6.05e-03 | -2.46e-01 | -0.191 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PGPEP1 | SNV | Missense_Mutation | c.146T>C | p.Val49Ala | p.V49A | Q9NXJ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PGPEP1 | SNV | Missense_Mutation | c.548N>A | p.Arg183Lys | p.R183K | Q9NXJ5 | protein_coding | tolerated(0.83) | benign(0.067) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PGPEP1 | SNV | Missense_Mutation | novel | c.477G>T | p.Gln159His | p.Q159H | Q9NXJ5 | protein_coding | tolerated(0.63) | possibly_damaging(0.87) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
PGPEP1 | SNV | Missense_Mutation | novel | c.584T>C | p.Leu195Pro | p.L195P | Q9NXJ5 | protein_coding | tolerated(0.21) | benign(0.121) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PGPEP1 | SNV | Missense_Mutation | rs748073683 | c.488N>A | p.Arg163Gln | p.R163Q | Q9NXJ5 | protein_coding | tolerated(0.24) | possibly_damaging(0.557) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PGPEP1 | SNV | Missense_Mutation | c.442C>A | p.Leu148Ile | p.L148I | Q9NXJ5 | protein_coding | tolerated(0.23) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PGPEP1 | SNV | Missense_Mutation | novel | c.52G>A | p.Glu18Lys | p.E18K | Q9NXJ5 | protein_coding | tolerated(0.07) | benign(0.111) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PGPEP1 | SNV | Missense_Mutation | rs532174440 | c.118G>A | p.Val40Met | p.V40M | Q9NXJ5 | protein_coding | deleterious(0.03) | probably_damaging(0.932) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PGPEP1 | SNV | Missense_Mutation | novel | c.218N>G | p.Val73Gly | p.V73G | Q9NXJ5 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-EY-A2OM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
PGPEP1 | SNV | Missense_Mutation | novel | c.289N>A | p.Asp97Asn | p.D97N | Q9NXJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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