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Gene: PGGT1B |
Gene summary for PGGT1B |
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Gene information | Species | Human | Gene symbol | PGGT1B | Gene ID | 5229 |
Gene name | protein geranylgeranyltransferase type I subunit beta | |
Gene Alias | BGGI | |
Cytomap | 5q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P53609 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5229 | PGGT1B | LZE4T | Human | Esophagus | ESCC | 2.24e-04 | 1.59e-01 | 0.0811 |
5229 | PGGT1B | LZE8T | Human | Esophagus | ESCC | 5.33e-03 | 6.78e-02 | 0.067 |
5229 | PGGT1B | LZE20T | Human | Esophagus | ESCC | 1.78e-03 | 9.97e-02 | 0.0662 |
5229 | PGGT1B | LZE24T | Human | Esophagus | ESCC | 4.11e-12 | 2.45e-01 | 0.0596 |
5229 | PGGT1B | P2T-E | Human | Esophagus | ESCC | 1.22e-17 | 2.40e-01 | 0.1177 |
5229 | PGGT1B | P4T-E | Human | Esophagus | ESCC | 1.73e-12 | 2.13e-01 | 0.1323 |
5229 | PGGT1B | P5T-E | Human | Esophagus | ESCC | 1.01e-06 | 7.65e-02 | 0.1327 |
5229 | PGGT1B | P8T-E | Human | Esophagus | ESCC | 1.60e-18 | 1.74e-01 | 0.0889 |
5229 | PGGT1B | P9T-E | Human | Esophagus | ESCC | 1.59e-06 | 1.48e-01 | 0.1131 |
5229 | PGGT1B | P10T-E | Human | Esophagus | ESCC | 1.84e-13 | 1.50e-01 | 0.116 |
5229 | PGGT1B | P11T-E | Human | Esophagus | ESCC | 1.69e-08 | 2.41e-01 | 0.1426 |
5229 | PGGT1B | P12T-E | Human | Esophagus | ESCC | 8.64e-18 | 2.26e-01 | 0.1122 |
5229 | PGGT1B | P15T-E | Human | Esophagus | ESCC | 2.70e-18 | 3.37e-01 | 0.1149 |
5229 | PGGT1B | P16T-E | Human | Esophagus | ESCC | 4.23e-08 | 6.46e-02 | 0.1153 |
5229 | PGGT1B | P17T-E | Human | Esophagus | ESCC | 2.44e-08 | 3.05e-01 | 0.1278 |
5229 | PGGT1B | P19T-E | Human | Esophagus | ESCC | 2.12e-07 | 2.92e-01 | 0.1662 |
5229 | PGGT1B | P20T-E | Human | Esophagus | ESCC | 4.82e-11 | 3.21e-01 | 0.1124 |
5229 | PGGT1B | P21T-E | Human | Esophagus | ESCC | 6.43e-08 | 1.39e-01 | 0.1617 |
5229 | PGGT1B | P22T-E | Human | Esophagus | ESCC | 6.86e-07 | 1.40e-01 | 0.1236 |
5229 | PGGT1B | P23T-E | Human | Esophagus | ESCC | 5.23e-12 | 2.90e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00457879 | Oral cavity | OSCC | positive regulation of cell cycle | 173/7305 | 313/18723 | 3.28e-09 | 7.44e-08 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PGGT1B | SNV | Missense_Mutation | rs761868131 | c.346N>A | p.Pro116Thr | p.P116T | P53609 | protein_coding | tolerated(0.29) | benign(0.087) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PGGT1B | SNV | Missense_Mutation | c.659N>C | p.Gly220Ala | p.G220A | P53609 | protein_coding | tolerated(0.05) | probably_damaging(0.957) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PGGT1B | SNV | Missense_Mutation | novel | c.453N>C | p.Leu151Phe | p.L151F | P53609 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PGGT1B | SNV | Missense_Mutation | novel | c.620N>G | p.Asp207Gly | p.D207G | P53609 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A1FH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PGGT1B | SNV | Missense_Mutation | c.608N>C | p.Ser203Thr | p.S203T | P53609 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD | |
PGGT1B | SNV | Missense_Mutation | c.37G>A | p.Gly13Ser | p.G13S | P53609 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PGGT1B | SNV | Missense_Mutation | novel | c.976N>C | p.Ile326Leu | p.I326L | P53609 | protein_coding | tolerated(1) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PGGT1B | SNV | Missense_Mutation | c.876N>T | p.Glu292Asp | p.E292D | P53609 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PGGT1B | SNV | Missense_Mutation | rs755476746 | c.160G>A | p.Ala54Thr | p.A54T | P53609 | protein_coding | deleterious(0) | benign(0.29) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PGGT1B | SNV | Missense_Mutation | novel | c.57T>A | p.Asp19Glu | p.D19E | P53609 | protein_coding | tolerated(0.89) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5229 | PGGT1B | ENZYME, DRUGGABLE GENOME | GGTI-2418 |
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