Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: PFN1

Gene summary for PFN1

Gene summary.

Gene information	Species	Human
	Gene symbol	PFN1
	Gene ID	5216
	Gene name	profilin 1
	Gene Alias	ALS18
	Cytomap	17p13.2
	Gene Type	protein-coding
	GO ID	GO:0001667
	UniProtAcc	P07737

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
5216	PFN1	GSM4909281	Human	Breast	IDC	1.34e-06	2.42e-01	0.21
5216	PFN1	GSM4909282	Human	Breast	IDC	2.68e-02	1.98e-01	-0.0288
5216	PFN1	GSM4909285	Human	Breast	IDC	1.13e-03	2.25e-01	0.21
5216	PFN1	GSM4909286	Human	Breast	IDC	4.52e-46	-6.45e-01	0.1081
5216	PFN1	GSM4909288	Human	Breast	IDC	1.43e-03	-4.62e-01	0.0988
5216	PFN1	GSM4909292	Human	Breast	IDC	1.10e-04	-8.23e-01	0.1236
5216	PFN1	GSM4909293	Human	Breast	IDC	4.09e-21	-3.77e-01	0.1581
5216	PFN1	GSM4909294	Human	Breast	IDC	3.40e-11	-5.08e-01	0.2022
5216	PFN1	GSM4909295	Human	Breast	IDC	1.03e-07	3.15e-01	0.0898
5216	PFN1	GSM4909296	Human	Breast	IDC	4.18e-05	2.11e-03	0.1524
5216	PFN1	GSM4909297	Human	Breast	IDC	1.37e-20	-2.39e-01	0.1517
5216	PFN1	GSM4909298	Human	Breast	IDC	1.09e-03	-1.17e-01	0.1551
5216	PFN1	GSM4909299	Human	Breast	IDC	2.69e-05	-1.93e-01	0.035
5216	PFN1	GSM4909301	Human	Breast	IDC	8.85e-38	4.08e-01	0.1577
5216	PFN1	GSM4909303	Human	Breast	IDC	2.04e-07	-5.90e-01	0.0438
5216	PFN1	GSM4909308	Human	Breast	IDC	2.83e-05	-1.08e-01	0.158
5216	PFN1	GSM4909311	Human	Breast	IDC	2.46e-49	-6.93e-01	0.1534
5216	PFN1	GSM4909312	Human	Breast	IDC	5.78e-04	-2.37e-01	0.1552
5216	PFN1	GSM4909317	Human	Breast	IDC	1.77e-19	-4.98e-01	0.1355
5216	PFN1	GSM4909319	Human	Breast	IDC	7.22e-65	-7.13e-01	0.1563

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Breast		IDC: Invasive ductal carcinoma
		DCIS: Ductal carcinoma in situ
		Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
GC		CAG: Chronic atrophic gastritis
		CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
		CSG: Chronic superficial gastritis
		GC: Gastric cancer
		SIM: Severe intestinal metaplasia
		WIM: Wild intestinal metaplasia
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Prostate		BPH: Benign Prostatic Hyperplasia
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00432549	Breast	Precancer	regulation of protein-containing complex assembly	50/1080	428/18723	1.63e-06	5.97e-05	50
GO:00508219	Breast	Precancer	protein stabilization	29/1080	191/18723	1.67e-06	6.08e-05	29
GO:00313349	Breast	Precancer	positive regulation of protein-containing complex assembly	33/1080	237/18723	2.39e-06	8.21e-05	33
GO:00316479	Breast	Precancer	regulation of protein stability	38/1080	298/18723	3.73e-06	1.19e-04	38
GO:00106348	Breast	Precancer	positive regulation of epithelial cell migration	25/1080	176/18723	2.75e-05	6.21e-04	25
GO:19029059	Breast	Precancer	positive regulation of supramolecular fiber organization	28/1080	209/18723	2.79e-05	6.28e-04	28
GO:00106319	Breast	Precancer	epithelial cell migration	40/1080	357/18723	4.57e-05	9.71e-04	40
GO:19029039	Breast	Precancer	regulation of supramolecular fiber organization	42/1080	383/18723	4.92e-05	1.04e-03	42
GO:00901329	Breast	Precancer	epithelium migration	40/1080	360/18723	5.51e-05	1.14e-03	40
GO:00901309	Breast	Precancer	tissue migration	40/1080	365/18723	7.48e-05	1.47e-03	40
GO:00329709	Breast	Precancer	regulation of actin filament-based process	42/1080	397/18723	1.11e-04	2.01e-03	42
GO:00514959	Breast	Precancer	positive regulation of cytoskeleton organization	28/1080	226/18723	1.13e-04	2.04e-03	28
GO:00106329	Breast	Precancer	regulation of epithelial cell migration	33/1080	292/18723	1.74e-04	2.86e-03	33
GO:00016678	Breast	Precancer	ameboidal-type cell migration	47/1080	475/18723	2.19e-04	3.35e-03	47
GO:00434624	Breast	Precancer	regulation of ATPase activity	10/1080	46/18723	2.38e-04	3.57e-03	10
GO:00070159	Breast	Precancer	actin filament organization	44/1080	442/18723	3.02e-04	4.35e-03	44
GO:00329569	Breast	Precancer	regulation of actin cytoskeleton organization	36/1080	358/18723	8.56e-04	9.88e-03	36
GO:00351486	Breast	Precancer	tube formation	19/1080	148/18723	8.79e-04	1.01e-02	19
GO:00322739	Breast	Precancer	positive regulation of protein polymerization	18/1080	138/18723	9.85e-04	1.11e-02	18
GO:00313338	Breast	Precancer	negative regulation of protein-containing complex assembly	18/1080	141/18723	1.27e-03	1.35e-02	18

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0501416	Breast	Precancer	Amyotrophic lateral sclerosis	98/684	364/8465	2.13e-28	8.41e-27	6.44e-27	98
hsa0513218	Breast	Precancer	Salmonella infection	49/684	249/8465	2.92e-09	6.15e-08	4.71e-08	49
hsa0513118	Breast	Precancer	Shigellosis	44/684	247/8465	3.91e-07	6.86e-06	5.26e-06	44
hsa0501417	Breast	Precancer	Amyotrophic lateral sclerosis	98/684	364/8465	2.13e-28	8.41e-27	6.44e-27	98
hsa0513219	Breast	Precancer	Salmonella infection	49/684	249/8465	2.92e-09	6.15e-08	4.71e-08	49
hsa0513119	Breast	Precancer	Shigellosis	44/684	247/8465	3.91e-07	6.86e-06	5.26e-06	44
hsa0501423	Breast	IDC	Amyotrophic lateral sclerosis	102/867	364/8465	1.29e-22	5.22e-21	3.91e-21	102
hsa0513224	Breast	IDC	Salmonella infection	55/867	249/8465	2.07e-08	4.49e-07	3.36e-07	55
hsa0513124	Breast	IDC	Shigellosis	47/867	247/8465	1.78e-05	2.00e-04	1.49e-04	47
hsa0481014	Breast	IDC	Regulation of actin cytoskeleton	36/867	229/8465	5.79e-03	3.13e-02	2.34e-02	36
hsa0501433	Breast	IDC	Amyotrophic lateral sclerosis	102/867	364/8465	1.29e-22	5.22e-21	3.91e-21	102
hsa0513234	Breast	IDC	Salmonella infection	55/867	249/8465	2.07e-08	4.49e-07	3.36e-07	55
hsa0513134	Breast	IDC	Shigellosis	47/867	247/8465	1.78e-05	2.00e-04	1.49e-04	47
hsa0481015	Breast	IDC	Regulation of actin cytoskeleton	36/867	229/8465	5.79e-03	3.13e-02	2.34e-02	36
hsa0501443	Breast	DCIS	Amyotrophic lateral sclerosis	101/846	364/8465	7.14e-23	2.88e-21	2.12e-21	101
hsa0513243	Breast	DCIS	Salmonella infection	55/846	249/8465	8.71e-09	1.87e-07	1.38e-07	55
hsa0513144	Breast	DCIS	Shigellosis	46/846	247/8465	2.06e-05	2.38e-04	1.75e-04	46
hsa0481023	Breast	DCIS	Regulation of actin cytoskeleton	35/846	229/8465	6.89e-03	3.37e-02	2.48e-02	35
hsa0501453	Breast	DCIS	Amyotrophic lateral sclerosis	101/846	364/8465	7.14e-23	2.88e-21	2.12e-21	101
hsa0513253	Breast	DCIS	Salmonella infection	55/846	249/8465	8.71e-09	1.87e-07	1.38e-07	55

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

PFN1

SNV

Missense_Mutation

novel

c.25N>C

p.Asp9His

p.D9H

P07737

protein_coding

tolerated(0.08)

possibly_damaging(0.771)

TCGA-DG-A2KK-01

Cervix

cervical & endocervical cancer

Female

<65

III/IV

Chemotherapy

cisplatin

PFN1

SNV

Missense_Mutation

c.349N>C

p.Glu117Gln

p.E117Q

P07737

protein_coding

deleterious(0.01)

possibly_damaging(0.517)

TCGA-HM-A4S6-01

Cervix

cervical & endocervical cancer

Female

<65

III/IV

Chemotherapy

cisplatin

PFN1

SNV

Missense_Mutation

c.349G>A

p.Glu117Lys

p.E117K

P07737

protein_coding

tolerated(0.15)

benign(0.26)

TCGA-ZJ-AAXU-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

PFN1

SNV

Missense_Mutation

c.401A>T

p.His134Leu

p.H134L

P07737

protein_coding

tolerated(0.12)

benign(0.019)

TCGA-CK-4951-01

Colorectum

colon adenocarcinoma

Female

>=65

I/II

Unknown

PFN1

SNV

Missense_Mutation

novel

c.197N>G

p.Leu66Arg

p.L66R

P07737

protein_coding

deleterious(0)

probably_damaging(0.992)

TCGA-A5-A1OF-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

PFN1

SNV

Missense_Mutation

novel

c.355N>A

p.Val119Ile

p.V119I

P07737

protein_coding

tolerated(0.13)

benign(0.001)

TCGA-AP-A059-01

Endometrium

uterine corpus endometrioid carcinoma

Female

>=65

I/II

Unknown

PFN1

SNV

Missense_Mutation

novel

c.382N>G

p.Cys128Gly

p.C128G

P07737

protein_coding

deleterious(0)

benign(0.184)

TCGA-AX-A1CE-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unspecific

Paclitaxel

PFN1

SNV

Missense_Mutation

c.313N>G

p.Lys105Glu

p.K105E

P07737

protein_coding

deleterious(0.04)

benign(0.068)

TCGA-D1-A174-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

PFN1

SNV

Missense_Mutation

novel

c.380N>G

p.Lys127Arg

p.K127R

P07737

protein_coding

deleterious(0.01)

benign(0.011)

TCGA-E6-A1LX-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

PFN1

SNV

Missense_Mutation

novel

c.172N>C

p.Ser58Arg

p.S58R

P07737

protein_coding

tolerated(0.27)

benign(0.224)

TCGA-EY-A1GI-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

Page: 1 2

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1