Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PDHX

Gene summary for PDHX

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PDHX

Gene ID

8050

Gene namepyruvate dehydrogenase complex component X
Gene AliasDLDBP
Cytomap11p13
Gene Typeprotein-coding
GO ID

GO:0006082

UniProtAcc

O00330


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8050PDHXLZE4THumanEsophagusESCC5.91e-103.97e-010.0811
8050PDHXLZE7THumanEsophagusESCC2.31e-094.62e-010.0667
8050PDHXLZE22THumanEsophagusESCC5.55e-033.13e-010.068
8050PDHXLZE24THumanEsophagusESCC2.65e-143.54e-010.0596
8050PDHXP1T-EHumanEsophagusESCC7.55e-032.63e-010.0875
8050PDHXP2T-EHumanEsophagusESCC5.66e-232.52e-010.1177
8050PDHXP4T-EHumanEsophagusESCC1.21e-062.44e-010.1323
8050PDHXP5T-EHumanEsophagusESCC1.79e-082.18e-020.1327
8050PDHXP8T-EHumanEsophagusESCC3.71e-263.25e-010.0889
8050PDHXP9T-EHumanEsophagusESCC8.25e-122.25e-010.1131
8050PDHXP10T-EHumanEsophagusESCC6.63e-201.82e-010.116
8050PDHXP11T-EHumanEsophagusESCC4.24e-043.76e-010.1426
8050PDHXP12T-EHumanEsophagusESCC2.20e-223.04e-010.1122
8050PDHXP15T-EHumanEsophagusESCC3.72e-183.70e-010.1149
8050PDHXP16T-EHumanEsophagusESCC3.35e-212.26e-010.1153
8050PDHXP20T-EHumanEsophagusESCC1.15e-092.45e-010.1124
8050PDHXP21T-EHumanEsophagusESCC3.85e-112.11e-010.1617
8050PDHXP22T-EHumanEsophagusESCC3.04e-386.36e-010.1236
8050PDHXP23T-EHumanEsophagusESCC5.88e-061.68e-010.108
8050PDHXP24T-EHumanEsophagusESCC4.44e-191.89e-010.1287
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006753110EsophagusESCCnucleoside phosphate metabolic process288/8552497/187231.80e-083.50e-07288
GO:0019693111EsophagusESCCribose phosphate metabolic process234/8552396/187234.24e-087.76e-07234
GO:0009117111EsophagusESCCnucleotide metabolic process282/8552489/187234.70e-088.50e-07282
GO:00067906EsophagusESCCsulfur compound metabolic process201/8552339/187232.64e-073.94e-06201
GO:0009259111EsophagusESCCribonucleotide metabolic process224/8552385/187234.41e-076.00e-06224
GO:0072521111EsophagusESCCpurine-containing compound metabolic process238/8552416/187231.20e-061.49e-05238
GO:0009150111EsophagusESCCpurine ribonucleotide metabolic process213/8552368/187231.40e-061.69e-05213
GO:0046390110EsophagusESCCribose phosphate biosynthetic process119/8552190/187231.73e-062.06e-05119
GO:00442725EsophagusESCCsulfur compound biosynthetic process96/8552148/187231.86e-062.16e-0596
GO:0006163111EsophagusESCCpurine nucleotide metabolic process226/8552396/187232.81e-063.21e-05226
GO:000916516EsophagusESCCnucleotide biosynthetic process150/8552254/187231.12e-051.06e-04150
GO:0009260110EsophagusESCCribonucleotide biosynthetic process112/8552182/187231.12e-051.06e-04112
GO:190129316EsophagusESCCnucleoside phosphate biosynthetic process151/8552256/187231.15e-051.08e-04151
GO:00338664EsophagusESCCnucleoside bisphosphate biosynthetic process44/855260/187231.25e-051.15e-0444
GO:00340304EsophagusESCCribonucleoside bisphosphate biosynthetic process44/855260/187231.25e-051.15e-0444
GO:00340334EsophagusESCCpurine nucleoside bisphosphate biosynthetic process44/855260/187231.25e-051.15e-0444
GO:007252217EsophagusESCCpurine-containing compound biosynthetic process120/8552200/187233.02e-052.51e-04120
GO:0009152110EsophagusESCCpurine ribonucleotide biosynthetic process103/8552169/187234.40e-053.51e-04103
GO:000616417EsophagusESCCpurine nucleotide biosynthetic process113/8552191/187231.16e-048.04e-04113
GO:00353844EsophagusESCCthioester biosynthetic process32/855245/187234.87e-042.70e-0332
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PDHXSNVMissense_Mutationnovelc.1328N>Ap.Gly443Glup.G443EO00330protein_codingdeleterious(0)probably_damaging(1)TCGA-E9-A1NE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinCR
PDHXinsertionNonsense_Mutationnovelc.757_758insGCTAAATATGTAATATTAGCATAACTAATATTAGCTATTAGCATAAp.Pro253ArgfsTer2p.P253Rfs*2O00330protein_codingTCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
PDHXinsertionNonsense_Mutationnovelc.1396_1397insAAACTAAAAAACACTAGATTGACCAGAATGGAp.Leu466GlnfsTer6p.L466Qfs*6O00330protein_codingTCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
PDHXdeletionFrame_Shift_Delnovelc.297delNp.Val100LeufsTer3p.V100Lfs*3O00330protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
PDHXSNVMissense_Mutationnovelc.548N>Tp.Arg183Leup.R183LO00330protein_codingtolerated(0.07)possibly_damaging(0.708)TCGA-EA-A4BA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinCR
PDHXSNVMissense_Mutationc.992N>Gp.Phe331Cysp.F331CO00330protein_codingdeleterious(0.03)possibly_damaging(0.617)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
PDHXSNVMissense_Mutationc.713N>Tp.Thr238Ilep.T238IO00330protein_codingtolerated(0.07)benign(0.047)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PDHXSNVMissense_Mutationnovelc.1357N>Ap.Glu453Lysp.E453KO00330protein_codingtolerated(0.08)benign(0.297)TCGA-MA-AA41-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PDHXSNVMissense_Mutationc.1427G>Ap.Arg476Glnp.R476QO00330protein_codingdeleterious(0.02)probably_damaging(0.978)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
PDHXSNVMissense_Mutationrs371811647c.1279N>Ap.Glu427Lysp.E427KO00330protein_codingtolerated(0.07)benign(0.206)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
8050PDHXKINASEAUTOANTIGEN8464876
8050PDHXKINASEANTIOXIDANT14607783
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