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Gene: PDCD2L |
Gene summary for PDCD2L |
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Gene information | Species | Human | Gene symbol | PDCD2L | Gene ID | 84306 |
Gene name | programmed cell death 2 like | |
Gene Alias | PDCD2L | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q9BRP1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84306 | PDCD2L | LZE7T | Human | Esophagus | ESCC | 9.21e-04 | 2.50e-01 | 0.0667 |
84306 | PDCD2L | LZE22T | Human | Esophagus | ESCC | 7.63e-03 | 2.46e-01 | 0.068 |
84306 | PDCD2L | LZE24T | Human | Esophagus | ESCC | 4.02e-06 | 1.92e-01 | 0.0596 |
84306 | PDCD2L | LZE6T | Human | Esophagus | ESCC | 9.07e-04 | 2.02e-01 | 0.0845 |
84306 | PDCD2L | P2T-E | Human | Esophagus | ESCC | 3.00e-11 | 1.42e-01 | 0.1177 |
84306 | PDCD2L | P4T-E | Human | Esophagus | ESCC | 3.18e-18 | 4.37e-01 | 0.1323 |
84306 | PDCD2L | P5T-E | Human | Esophagus | ESCC | 6.54e-16 | 3.62e-01 | 0.1327 |
84306 | PDCD2L | P8T-E | Human | Esophagus | ESCC | 1.75e-16 | 2.19e-01 | 0.0889 |
84306 | PDCD2L | P9T-E | Human | Esophagus | ESCC | 2.08e-13 | 2.75e-01 | 0.1131 |
84306 | PDCD2L | P10T-E | Human | Esophagus | ESCC | 7.48e-13 | 3.31e-01 | 0.116 |
84306 | PDCD2L | P11T-E | Human | Esophagus | ESCC | 9.94e-04 | 2.18e-01 | 0.1426 |
84306 | PDCD2L | P12T-E | Human | Esophagus | ESCC | 8.47e-20 | 3.65e-01 | 0.1122 |
84306 | PDCD2L | P15T-E | Human | Esophagus | ESCC | 4.99e-15 | 3.12e-01 | 0.1149 |
84306 | PDCD2L | P16T-E | Human | Esophagus | ESCC | 6.14e-07 | 1.35e-01 | 0.1153 |
84306 | PDCD2L | P20T-E | Human | Esophagus | ESCC | 1.04e-10 | 2.86e-01 | 0.1124 |
84306 | PDCD2L | P21T-E | Human | Esophagus | ESCC | 3.29e-10 | 1.88e-01 | 0.1617 |
84306 | PDCD2L | P22T-E | Human | Esophagus | ESCC | 3.10e-13 | 2.19e-01 | 0.1236 |
84306 | PDCD2L | P23T-E | Human | Esophagus | ESCC | 1.61e-17 | 4.34e-01 | 0.108 |
84306 | PDCD2L | P24T-E | Human | Esophagus | ESCC | 5.05e-13 | 3.07e-01 | 0.1287 |
84306 | PDCD2L | P26T-E | Human | Esophagus | ESCC | 9.62e-18 | 3.23e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCD2L | SNV | Missense_Mutation | c.1027N>A | p.Glu343Lys | p.E343K | Q9BRP1 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PDCD2L | SNV | Missense_Mutation | novel | c.397N>A | p.Asp133Asn | p.D133N | Q9BRP1 | protein_coding | tolerated(0.09) | benign(0.09) | TCGA-LL-A6FP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PDCD2L | insertion | Frame_Shift_Ins | novel | c.408_409insAGCTGCTATGCCACCTCTCCTGCTGTCAGGAAGCTTAGGTGTGATCT | p.Gly137SerfsTer36 | p.G137Sfs*36 | Q9BRP1 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
PDCD2L | insertion | Nonsense_Mutation | novel | c.862_863insGGATGTGGGGCATGGTTTTGGGATGAAACTGTTCA | p.Ala288GlyfsTer9 | p.A288Gfs*9 | Q9BRP1 | protein_coding | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
PDCD2L | insertion | Frame_Shift_Ins | novel | c.864_865insTCAGATCA | p.Cys289SerfsTer30 | p.C289Sfs*30 | Q9BRP1 | protein_coding | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
PDCD2L | insertion | Frame_Shift_Ins | novel | c.558_559insTTCTTGAACTCCTGGACTCAAACAGT | p.Pro187PhefsTer34 | p.P187Ffs*34 | Q9BRP1 | protein_coding | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
PDCD2L | SNV | Missense_Mutation | novel | c.32G>A | p.Gly11Asp | p.G11D | Q9BRP1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD2L | SNV | Missense_Mutation | novel | c.214N>G | p.His72Asp | p.H72D | Q9BRP1 | protein_coding | deleterious(0.02) | benign(0.24) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PDCD2L | SNV | Missense_Mutation | novel | c.807G>C | p.Trp269Cys | p.W269C | Q9BRP1 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD2L | SNV | Missense_Mutation | novel | c.973C>G | p.Leu325Val | p.L325V | Q9BRP1 | protein_coding | tolerated(0.08) | probably_damaging(0.953) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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