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Gene: PDCD11 |
Gene summary for PDCD11 |
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Gene information | Species | Human | Gene symbol | PDCD11 | Gene ID | 22984 |
Gene name | programmed cell death 11 | |
Gene Alias | ALG-4 | |
Cytomap | 10q24.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14690 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22984 | PDCD11 | LZE4T | Human | Esophagus | ESCC | 2.20e-02 | 9.79e-02 | 0.0811 |
22984 | PDCD11 | LZE24T | Human | Esophagus | ESCC | 2.10e-04 | 1.27e-01 | 0.0596 |
22984 | PDCD11 | P1T-E | Human | Esophagus | ESCC | 5.89e-03 | 1.20e-01 | 0.0875 |
22984 | PDCD11 | P2T-E | Human | Esophagus | ESCC | 1.79e-13 | 3.08e-01 | 0.1177 |
22984 | PDCD11 | P4T-E | Human | Esophagus | ESCC | 1.61e-13 | 3.05e-01 | 0.1323 |
22984 | PDCD11 | P5T-E | Human | Esophagus | ESCC | 2.52e-11 | 2.26e-01 | 0.1327 |
22984 | PDCD11 | P8T-E | Human | Esophagus | ESCC | 1.05e-05 | 1.53e-01 | 0.0889 |
22984 | PDCD11 | P9T-E | Human | Esophagus | ESCC | 6.25e-05 | 4.37e-02 | 0.1131 |
22984 | PDCD11 | P10T-E | Human | Esophagus | ESCC | 7.70e-04 | 8.95e-02 | 0.116 |
22984 | PDCD11 | P11T-E | Human | Esophagus | ESCC | 1.31e-06 | 1.58e-01 | 0.1426 |
22984 | PDCD11 | P12T-E | Human | Esophagus | ESCC | 1.53e-08 | 1.77e-01 | 0.1122 |
22984 | PDCD11 | P15T-E | Human | Esophagus | ESCC | 5.57e-09 | 1.66e-01 | 0.1149 |
22984 | PDCD11 | P16T-E | Human | Esophagus | ESCC | 1.22e-39 | 1.35e+00 | 0.1153 |
22984 | PDCD11 | P17T-E | Human | Esophagus | ESCC | 2.05e-02 | 1.26e-01 | 0.1278 |
22984 | PDCD11 | P20T-E | Human | Esophagus | ESCC | 8.42e-16 | 1.86e-01 | 0.1124 |
22984 | PDCD11 | P21T-E | Human | Esophagus | ESCC | 1.14e-09 | 1.73e-01 | 0.1617 |
22984 | PDCD11 | P22T-E | Human | Esophagus | ESCC | 9.40e-09 | 1.09e-01 | 0.1236 |
22984 | PDCD11 | P23T-E | Human | Esophagus | ESCC | 5.92e-16 | 2.92e-01 | 0.108 |
22984 | PDCD11 | P26T-E | Human | Esophagus | ESCC | 1.58e-08 | 2.50e-01 | 0.1276 |
22984 | PDCD11 | P27T-E | Human | Esophagus | ESCC | 2.89e-07 | 2.81e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCD11 | SNV | Missense_Mutation | c.112G>A | p.Glu38Lys | p.E38K | Q14690 | protein_coding | tolerated(0.09) | benign(0.076) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PDCD11 | SNV | Missense_Mutation | novel | c.1244A>G | p.Asn415Ser | p.N415S | Q14690 | protein_coding | tolerated(0.93) | benign(0) | TCGA-A2-A3XX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
PDCD11 | SNV | Missense_Mutation | novel | c.391C>G | p.Gln131Glu | p.Q131E | Q14690 | protein_coding | tolerated(1) | benign(0) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD11 | SNV | Missense_Mutation | rs772009790 | c.1036N>T | p.Arg346Cys | p.R346C | Q14690 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD11 | SNV | Missense_Mutation | c.3604G>T | p.Ala1202Ser | p.A1202S | Q14690 | protein_coding | tolerated(0.05) | possibly_damaging(0.472) | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD | ||
PDCD11 | SNV | Missense_Mutation | c.4340N>T | p.Gln1447Leu | p.Q1447L | Q14690 | protein_coding | tolerated(0.4) | benign(0.058) | TCGA-AR-A1AU-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
PDCD11 | SNV | Missense_Mutation | c.2482N>G | p.Leu828Val | p.L828V | Q14690 | protein_coding | tolerated(0.1) | benign(0.345) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
PDCD11 | SNV | Missense_Mutation | novel | c.1025N>C | p.His342Pro | p.H342P | Q14690 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
PDCD11 | SNV | Missense_Mutation | c.1251N>G | p.His417Gln | p.H417Q | Q14690 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDCD11 | SNV | Missense_Mutation | c.1531G>C | p.Asp511His | p.D511H | Q14690 | protein_coding | tolerated(0.09) | probably_damaging(0.972) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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