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Gene: PCNX |
Gene summary for PCNX |
Gene summary. |
Gene information | Species | Human | Gene symbol | PCNX | Gene ID | 22990 |
Gene name | pecanex 1 | |
Gene Alias | PCNX | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96RV3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22990 | PCNX | P2T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.26e-01 | 0.1177 |
22990 | PCNX | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 1.70e-01 | 0.1323 |
22990 | PCNX | P5T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.27e-01 | 0.1327 |
22990 | PCNX | P8T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.95e-01 | 0.0889 |
22990 | PCNX | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.22e-01 | 0.1131 |
22990 | PCNX | P10T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.38e-01 | 0.116 |
22990 | PCNX | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 4.41e-01 | 0.1426 |
22990 | PCNX | P12T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.97e-01 | 0.1122 |
22990 | PCNX | P15T-E | Human | Esophagus | ESCC | 1.52e-21 | 4.34e-01 | 0.1149 |
22990 | PCNX | P16T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.97e-01 | 0.1153 |
22990 | PCNX | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.50e-01 | 0.1662 |
22990 | PCNX | P20T-E | Human | Esophagus | ESCC | 8.62e-07 | 1.71e-01 | 0.1124 |
22990 | PCNX | P21T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.08e-01 | 0.1617 |
22990 | PCNX | P22T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.94e-01 | 0.1236 |
22990 | PCNX | P23T-E | Human | Esophagus | ESCC | 3.88e-04 | 1.34e-01 | 0.108 |
22990 | PCNX | P24T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.64e-01 | 0.1287 |
22990 | PCNX | P26T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.79e-01 | 0.1276 |
22990 | PCNX | P27T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.70e-01 | 0.1055 |
22990 | PCNX | P28T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.92e-01 | 0.1149 |
22990 | PCNX | P30T-E | Human | Esophagus | ESCC | 6.12e-09 | 2.68e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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