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Gene: PCDH11X |
Gene summary for PCDH11X |
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Gene information | Species | Human | Gene symbol | PCDH11X | Gene ID | 27328 |
Gene name | protocadherin 11 X-linked | |
Gene Alias | PCDH-X | |
Cytomap | Xq21.31 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q9BZA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27328 | PCDH11X | p6 | Human | Liver | Cyst | 9.43e-17 | 7.23e-01 | -0.0218 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCDH11X | SNV | Missense_Mutation | novel | c.3064N>A | p.Pro1022Thr | p.P1022T | Q9BZA7 | protein_coding | deleterious(0.04) | benign(0.205) | TCGA-A2-A4S1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | c.331N>C | p.Glu111Gln | p.E111Q | Q9BZA7 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PCDH11X | SNV | Missense_Mutation | c.3573N>T | p.Gln1191His | p.Q1191H | Q9BZA7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.601) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PCDH11X | SNV | Missense_Mutation | c.333N>T | p.Glu111Asp | p.E111D | Q9BZA7 | protein_coding | tolerated(0.15) | probably_damaging(0.999) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCDH11X | SNV | Missense_Mutation | c.529N>A | p.Glu177Lys | p.E177K | Q9BZA7 | protein_coding | tolerated(0.11) | benign(0.056) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PCDH11X | SNV | Missense_Mutation | novel | c.2509C>T | p.Arg837Cys | p.R837C | Q9BZA7 | protein_coding | tolerated(0.11) | benign(0.075) | TCGA-AC-A3OD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | novel | c.1943N>T | p.Gly648Val | p.G648V | Q9BZA7 | protein_coding | deleterious(0.01) | possibly_damaging(0.772) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | rs369246059 | c.2314G>A | p.Val772Met | p.V772M | Q9BZA7 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCDH11X | SNV | Missense_Mutation | novel | c.730G>A | p.Asp244Asn | p.D244N | Q9BZA7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B6-A2IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PCDH11X | SNV | Missense_Mutation | c.3502N>A | p.Ala1168Thr | p.A1168T | Q9BZA7 | protein_coding | tolerated_low_confidence(0.38) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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