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Gene: PCAT1 |
Gene summary for PCAT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PCAT1 | Gene ID | 100750225 |
| Gene name | prostate cancer associated transcript 1 | |
| Gene Alias | PCA1 | |
| Cytomap | 8q24.21 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100750225 | PCAT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.31e-10 | -4.46e-01 | 0.0155 |
| 100750225 | PCAT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.09e-05 | -4.24e-01 | -0.1088 |
| 100750225 | PCAT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.32e-03 | -4.32e-01 | -0.1207 |
| 100750225 | PCAT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.70e-06 | -3.20e-01 | -0.1464 |
| 100750225 | PCAT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.54e-10 | -4.00e-01 | -0.1001 |
| 100750225 | PCAT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.31e-02 | -5.06e-01 | -0.2061 |
| 100750225 | PCAT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.75e-04 | -3.70e-01 | 0.096 |
| 100750225 | PCAT1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.52e-04 | -4.12e-01 | 0.0338 |
| 100750225 | PCAT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.36e-10 | -4.07e-01 | 0.0674 |
| 100750225 | PCAT1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.20e-03 | -3.00e-01 | 0.0588 |
| 100750225 | PCAT1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.24e-03 | -1.65e-01 | 0.3859 |
| 100750225 | PCAT1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.92e-02 | -4.42e-01 | 0.2585 |
| 100750225 | PCAT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.52e-08 | -3.52e-01 | 0.3005 |
| 100750225 | PCAT1 | A015-C-203 | Human | Colorectum | FAP | 6.81e-07 | -1.48e-01 | -0.1294 |
| 100750225 | PCAT1 | A002-C-201 | Human | Colorectum | FAP | 1.68e-03 | -2.46e-01 | 0.0324 |
| 100750225 | PCAT1 | A002-C-205 | Human | Colorectum | FAP | 1.14e-06 | -2.34e-01 | -0.1236 |
| 100750225 | PCAT1 | A015-C-006 | Human | Colorectum | FAP | 1.28e-02 | 3.32e-02 | -0.0994 |
| 100750225 | PCAT1 | A002-C-114 | Human | Colorectum | FAP | 9.77e-05 | -2.40e-01 | -0.1561 |
| 100750225 | PCAT1 | A015-C-104 | Human | Colorectum | FAP | 2.29e-08 | -2.09e-01 | -0.1899 |
| 100750225 | PCAT1 | A002-C-016 | Human | Colorectum | FAP | 5.49e-05 | -1.21e-01 | 0.0521 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
| GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
| GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
| GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
| GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
| GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
| GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
| GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
| GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
| GO:00066561 | Esophagus | ESCC | phosphatidylcholine biosynthetic process | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
| GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
| GO:00066541 | Esophagus | ESCC | phosphatidic acid biosynthetic process | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
| GO:00464733 | Esophagus | ESCC | phosphatidic acid metabolic process | 28/8552 | 37/18723 | 2.00e-04 | 1.26e-03 | 28 |
| GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
| GO:01501724 | Esophagus | ESCC | regulation of phosphatidylcholine metabolic process | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
| GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
| GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
| GO:004217622 | Liver | HCC | regulation of protein catabolic process | 267/7958 | 391/18723 | 2.45e-25 | 7.38e-23 | 267 |
| GO:004573222 | Liver | HCC | positive regulation of protein catabolic process | 163/7958 | 231/18723 | 4.00e-18 | 4.69e-16 | 163 |
| GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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