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Gene: PBOV1 |
Gene summary for PBOV1 |
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Gene information | Species | Human | Gene symbol | PBOV1 | Gene ID | 59351 |
Gene name | prostate and breast cancer overexpressed 1 | |
Gene Alias | UC28 | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9GZY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59351 | PBOV1 | HCC1 | Human | Liver | HCC | 1.33e-05 | 8.73e-01 | 0.5336 |
59351 | PBOV1 | HCC2 | Human | Liver | HCC | 5.93e-12 | 1.27e+00 | 0.5341 |
59351 | PBOV1 | HCC5 | Human | Liver | HCC | 1.19e-05 | 5.04e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PBOV1 | SNV | Missense_Mutation | novel | c.309A>C | p.Glu103Asp | p.E103D | Q9GZY1 | protein_coding | tolerated_low_confidence(0.11) | benign(0.122) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PBOV1 | SNV | Missense_Mutation | c.139N>T | p.Pro47Ser | p.P47S | Q9GZY1 | protein_coding | tolerated_low_confidence(0.54) | benign(0.014) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
PBOV1 | SNV | Missense_Mutation | c.204N>A | p.Phe68Leu | p.F68L | Q9GZY1 | protein_coding | tolerated_low_confidence(0.45) | benign(0.067) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PBOV1 | SNV | Missense_Mutation | novel | c.399N>T | p.Gln133His | p.Q133H | Q9GZY1 | protein_coding | deleterious_low_confidence(0.04) | benign(0.192) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PBOV1 | SNV | Missense_Mutation | novel | c.208N>T | p.Asp70Tyr | p.D70Y | Q9GZY1 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.973) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBOV1 | SNV | Missense_Mutation | novel | c.100N>G | p.Arg34Gly | p.R34G | Q9GZY1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.882) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PBOV1 | SNV | Missense_Mutation | novel | c.128N>A | p.Thr43Asn | p.T43N | Q9GZY1 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PBOV1 | SNV | Missense_Mutation | novel | c.53N>G | p.His18Arg | p.H18R | Q9GZY1 | protein_coding | deleterious_low_confidence(0) | benign(0.1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PBOV1 | SNV | Missense_Mutation | c.204C>A | p.Phe68Leu | p.F68L | Q9GZY1 | protein_coding | tolerated_low_confidence(0.45) | benign(0.067) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
PBOV1 | SNV | Missense_Mutation | c.143N>A | p.Phe48Tyr | p.F48Y | Q9GZY1 | protein_coding | tolerated_low_confidence(0.09) | benign(0.063) | TCGA-J2-8192-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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