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Gene: PBLD |
Gene summary for PBLD |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PBLD | Gene ID | 64081 |
| Gene name | phenazine biosynthesis like protein domain containing | |
| Gene Alias | HEL-S-306 | |
| Cytomap | 10q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | P30039 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64081 | PBLD | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.19e-08 | 6.31e-01 | -0.0811 |
| 64081 | PBLD | HTA11_347_2000001011 | Human | Colorectum | AD | 2.37e-21 | 8.44e-01 | -0.1954 |
| 64081 | PBLD | HTA11_696_2000001011 | Human | Colorectum | AD | 6.64e-03 | 3.91e-01 | -0.1464 |
| 64081 | PBLD | HTA11_866_2000001011 | Human | Colorectum | AD | 1.57e-06 | 5.07e-01 | -0.1001 |
| 64081 | PBLD | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.55e-06 | 5.66e-01 | -0.059 |
| 64081 | PBLD | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.66e-03 | -1.82e-01 | 0.3005 |
| 64081 | PBLD | A015-C-203 | Human | Colorectum | FAP | 1.96e-07 | -1.11e-01 | -0.1294 |
| 64081 | PBLD | A002-C-201 | Human | Colorectum | FAP | 1.40e-05 | -1.71e-01 | 0.0324 |
| 64081 | PBLD | A001-C-108 | Human | Colorectum | FAP | 1.62e-04 | -9.43e-02 | -0.0272 |
| 64081 | PBLD | A002-C-205 | Human | Colorectum | FAP | 5.86e-06 | -1.06e-01 | -0.1236 |
| 64081 | PBLD | A015-C-006 | Human | Colorectum | FAP | 1.85e-05 | -2.10e-01 | -0.0994 |
| 64081 | PBLD | A002-C-114 | Human | Colorectum | FAP | 1.25e-04 | -8.95e-02 | -0.1561 |
| 64081 | PBLD | A015-C-104 | Human | Colorectum | FAP | 5.83e-10 | -8.81e-02 | -0.1899 |
| 64081 | PBLD | A001-C-014 | Human | Colorectum | FAP | 2.27e-03 | -1.23e-01 | 0.0135 |
| 64081 | PBLD | A002-C-016 | Human | Colorectum | FAP | 1.52e-05 | -8.12e-02 | 0.0521 |
| 64081 | PBLD | A015-C-002 | Human | Colorectum | FAP | 7.93e-05 | -2.41e-01 | -0.0763 |
| 64081 | PBLD | A001-C-007 | Human | Colorectum | CRC | 5.72e-03 | -2.65e-01 | 0.1899 |
| 64081 | PBLD | A002-C-116 | Human | Colorectum | FAP | 6.46e-09 | 3.12e-02 | -0.0452 |
| 64081 | PBLD | A014-C-008 | Human | Colorectum | FAP | 1.39e-04 | -2.06e-01 | -0.191 |
| 64081 | PBLD | A018-E-020 | Human | Colorectum | FAP | 1.30e-05 | 1.97e-04 | -0.2034 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
| GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
| GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
| GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
| GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
| GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
| GO:0060390 | Colorectum | AD | regulation of SMAD protein signal transduction | 14/3918 | 31/18723 | 2.10e-03 | 1.67e-02 | 14 |
| GO:0060395 | Colorectum | AD | SMAD protein signal transduction | 28/3918 | 82/18723 | 3.73e-03 | 2.63e-02 | 28 |
| GO:0030277 | Colorectum | AD | maintenance of gastrointestinal epithelium | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
| GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
| GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
| GO:00603901 | Colorectum | MSS | regulation of SMAD protein signal transduction | 14/3467 | 31/18723 | 5.98e-04 | 6.60e-03 | 14 |
| GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
| GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
| GO:00715591 | Colorectum | FAP | response to transforming growth factor beta | 63/2622 | 256/18723 | 3.82e-06 | 1.32e-04 | 63 |
| GO:00071782 | Colorectum | FAP | transmembrane receptor protein serine/threonine kinase signaling pathway | 81/2622 | 355/18723 | 4.28e-06 | 1.46e-04 | 81 |
| GO:00715601 | Colorectum | FAP | cellular response to transforming growth factor beta stimulus | 61/2622 | 250/18723 | 7.22e-06 | 2.19e-04 | 61 |
| GO:00071791 | Colorectum | FAP | transforming growth factor beta receptor signaling pathway | 50/2622 | 198/18723 | 1.75e-05 | 4.44e-04 | 50 |
| GO:00018944 | Colorectum | FAP | tissue homeostasis | 61/2622 | 268/18723 | 6.71e-05 | 1.28e-03 | 61 |
| GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PBLD | insertion | Nonsense_Mutation | novel | c.551_552insCAGGGCTCAGAACTTTCAGTGCTAAAACCAGAAC | p.Leu185ArgfsTer8 | p.L185Rfs*8 | P30039 | protein_coding | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| PBLD | SNV | Missense_Mutation | c.59N>T | p.Pro20Leu | p.P20L | P30039 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
| PBLD | SNV | Missense_Mutation | c.607N>A | p.Glu203Lys | p.E203K | P30039 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
| PBLD | SNV | Missense_Mutation | rs750680281 | c.299N>T | p.Thr100Met | p.T100M | P30039 | protein_coding | deleterious(0.04) | benign(0.017) | TCGA-VS-A8QH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
| PBLD | SNV | Missense_Mutation | novel | c.709N>A | p.Leu237Ile | p.L237I | P30039 | protein_coding | deleterious(0.04) | possibly_damaging(0.884) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PBLD | SNV | Missense_Mutation | novel | c.358N>A | p.Val120Ile | p.V120I | P30039 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-AX-A3G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| PBLD | SNV | Missense_Mutation | c.514N>C | p.Ser172Pro | p.S172P | P30039 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| PBLD | SNV | Missense_Mutation | c.814N>A | p.Val272Ile | p.V272I | P30039 | protein_coding | tolerated(0.21) | benign(0.057) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| PBLD | SNV | Missense_Mutation | novel | c.525N>T | p.Glu175Asp | p.E175D | P30039 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PBLD | SNV | Missense_Mutation | novel | c.836C>A | p.Ala279Asp | p.A279D | P30039 | protein_coding | deleterious(0.03) | benign(0.295) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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