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Gene: PAX8-AS1 |
Gene summary for PAX8-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PAX8-AS1 | Gene ID | 654433 |
Gene name | PAX8 antisense RNA 1 | |
Gene Alias | PAX8-AS1 | |
Cytomap | 2q14.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
654433 | PAX8-AS1 | sample1 | Human | Cervix | CC | 1.65e-06 | 2.51e-01 | 0.0959 |
654433 | PAX8-AS1 | sample3 | Human | Cervix | CC | 6.41e-50 | 6.51e-01 | 0.1387 |
654433 | PAX8-AS1 | L1 | Human | Cervix | CC | 8.39e-03 | 1.98e-01 | 0.0802 |
654433 | PAX8-AS1 | T1 | Human | Cervix | CC | 3.55e-18 | 3.70e-01 | 0.0918 |
654433 | PAX8-AS1 | T2 | Human | Cervix | CC | 8.72e-04 | 1.96e-01 | 0.0709 |
654433 | PAX8-AS1 | T3 | Human | Cervix | CC | 9.62e-53 | 6.31e-01 | 0.1389 |
654433 | PAX8-AS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.22e-13 | 2.70e-01 | 0.0155 |
654433 | PAX8-AS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.54e-19 | 5.41e-01 | -0.1808 |
654433 | PAX8-AS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.83e-13 | 3.71e-01 | -0.0811 |
654433 | PAX8-AS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.07e-15 | 5.27e-01 | -0.1088 |
654433 | PAX8-AS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.64e-06 | 1.91e-01 | -0.1954 |
654433 | PAX8-AS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 4.03e-01 | -0.2602 |
654433 | PAX8-AS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 1.57e-01 | -0.1207 |
654433 | PAX8-AS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.92e-07 | 2.97e-01 | -0.1526 |
654433 | PAX8-AS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-19 | 3.88e-01 | -0.1464 |
654433 | PAX8-AS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.36e-09 | 3.61e-01 | -0.0842 |
654433 | PAX8-AS1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.38e-12 | 4.04e-01 | -0.0179 |
654433 | PAX8-AS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.85e-21 | 4.25e-01 | 0.096 |
654433 | PAX8-AS1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.41e-01 | 0.0446 |
654433 | PAX8-AS1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 1.62e-01 | 0.0528 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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