|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: PATZ1 |
Gene summary for PATZ1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PATZ1 | Gene ID | 23598 |
| Gene name | POZ/BTB and AT hook containing zinc finger 1 | |
| Gene Alias | MAZR | |
| Cytomap | 22q12.2 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R1M5 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23598 | PATZ1 | HCC1_Meng | Human | Liver | HCC | 1.13e-39 | 5.28e-02 | 0.0246 |
| 23598 | PATZ1 | HCC2_Meng | Human | Liver | HCC | 1.86e-06 | 2.33e-02 | 0.0107 |
| 23598 | PATZ1 | cirrhotic2 | Human | Liver | Cirrhotic | 3.47e-05 | 1.65e-01 | 0.0201 |
| 23598 | PATZ1 | HCC1 | Human | Liver | HCC | 3.53e-03 | 2.68e+00 | 0.5336 |
| 23598 | PATZ1 | HCC2 | Human | Liver | HCC | 1.74e-06 | 2.26e+00 | 0.5341 |
| 23598 | PATZ1 | S014 | Human | Liver | HCC | 4.56e-17 | 6.54e-01 | 0.2254 |
| 23598 | PATZ1 | S015 | Human | Liver | HCC | 2.99e-12 | 6.67e-01 | 0.2375 |
| 23598 | PATZ1 | S016 | Human | Liver | HCC | 1.60e-10 | 5.30e-01 | 0.2243 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00614585 | Liver | Cirrhotic | reproductive system development | 132/4634 | 427/18723 | 2.07e-03 | 1.28e-02 | 132 |
| GO:00486085 | Liver | Cirrhotic | reproductive structure development | 131/4634 | 424/18723 | 2.19e-03 | 1.34e-02 | 131 |
| GO:000166712 | Liver | Cirrhotic | ameboidal-type cell migration | 145/4634 | 475/18723 | 2.23e-03 | 1.36e-02 | 145 |
| GO:00106327 | Liver | Cirrhotic | regulation of epithelial cell migration | 93/4634 | 292/18723 | 3.46e-03 | 1.92e-02 | 93 |
| GO:00106317 | Liver | Cirrhotic | epithelial cell migration | 110/4634 | 357/18723 | 5.14e-03 | 2.65e-02 | 110 |
| GO:00901327 | Liver | Cirrhotic | epithelium migration | 110/4634 | 360/18723 | 6.79e-03 | 3.35e-02 | 110 |
| GO:00901307 | Liver | Cirrhotic | tissue migration | 111/4634 | 365/18723 | 7.66e-03 | 3.61e-02 | 111 |
| GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
| GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| PATZ1 | IMGOB | Colorectum | Healthy | NME3,OR8D4,ITPKB, etc. | 2.05e-01 |  |
| PATZ1 | MVA | Endometrium | ADJ | BCL11A,ZNF814,AC015922.3, etc. | 2.02e-02 |  |
| PATZ1 | MVA | Endometrium | AEH | BCL11A,ZNF814,AC015922.3, etc. | 3.14e-02 |  |
| PATZ1 | MEGA | Liver | Cirrhotic | ZNF667,CASQ2,MIS12, etc. | 2.79e-01 |  |
| PATZ1 | HSC | Liver | Cirrhotic | ZNF667,CASQ2,MIS12, etc. | 3.40e-01 | |
| PATZ1 | END | Liver | HCC | ZNF667,CASQ2,MIS12, etc. | 3.30e-01 |  |
| PATZ1 | HSC | Liver | NAFLD | ZNF667,CASQ2,MIS12, etc. | 1.02e-01 |  |
| PATZ1 | CD8TEREX | Lung | MIAC | CCDC77,SNHG31,AC016074.2, etc. | 3.56e-02 |  |
| PATZ1 | INMON | Oral cavity | OSCC | HES6,TAFA2,SYAP1, etc. | 1.41e-01 |  |
| PATZ1 | MYOFIB | Skin | AK | SPDYE2,AC018647.1,URB2, etc. | 2.45e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PATZ1 | SNV | Missense_Mutation | novel | c.884N>T | p.Gly295Val | p.G295V | Q9HBE1 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-BH-A0C7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| PATZ1 | SNV | Missense_Mutation | c.1901N>A | p.Gly634Asp | p.G634D | Q9HBE1 | protein_coding | tolerated(0.12) | benign(0.42) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| PATZ1 | insertion | Frame_Shift_Ins | novel | c.965_966insGCCGGATTCCTCAGGCCAGAGCCACC | p.Tyr323ProfsTer115 | p.Y323Pfs*115 | Q9HBE1 | protein_coding | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | ||
| PATZ1 | deletion | Frame_Shift_Del | novel | c.1269delC | p.Arg424GlyfsTer5 | p.R424Gfs*5 | Q9HBE1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| PATZ1 | deletion | Frame_Shift_Del | novel | c.1616delT | p.Phe539SerfsTer36 | p.F539Sfs*36 | Q9HBE1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| PATZ1 | SNV | Missense_Mutation | c.307N>C | p.Glu103Gln | p.E103Q | Q9HBE1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| PATZ1 | SNV | Missense_Mutation | c.1016C>G | p.Ser339Cys | p.S339C | Q9HBE1 | protein_coding | deleterious(0.01) | benign(0.39) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
| PATZ1 | deletion | Frame_Shift_Del | c.533delC | p.Pro178LeufsTer12 | p.P178Lfs*12 | Q9HBE1 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
| PATZ1 | insertion | Frame_Shift_Ins | novel | c.1202_1203insA | p.His401GlnfsTer6 | p.H401Qfs*6 | Q9HBE1 | protein_coding | TCGA-EK-A2RB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
| PATZ1 | SNV | Missense_Mutation | novel | c.1064N>G | p.Val355Gly | p.V355G | Q9HBE1 | protein_coding | tolerated(0.11) | probably_damaging(0.996) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |