Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PARVA

Gene summary for PARVA

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PARVA

Gene ID

55742

Gene nameparvin alpha
Gene AliasCH-ILKBP
Cytomap11p15.3
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

J3KNQ4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55742PARVAHTA11_99999974143_84620HumanColorectumMSS7.72e-09-3.40e-010.3005
55742PARVAF007HumanColorectumFAP4.27e-03-3.41e-010.1176
55742PARVAA002-C-010HumanColorectumFAP6.28e-05-1.80e-010.242
55742PARVAA001-C-207HumanColorectumFAP1.13e-03-3.25e-010.1278
55742PARVAA015-C-203HumanColorectumFAP1.81e-29-5.57e-01-0.1294
55742PARVAA015-C-204HumanColorectumFAP1.60e-09-4.50e-01-0.0228
55742PARVAA014-C-040HumanColorectumFAP1.75e-03-4.79e-01-0.1184
55742PARVAA002-C-201HumanColorectumFAP2.48e-14-4.76e-010.0324
55742PARVAA002-C-203HumanColorectumFAP1.27e-06-2.35e-010.2786
55742PARVAA001-C-119HumanColorectumFAP1.05e-12-5.51e-01-0.1557
55742PARVAA001-C-108HumanColorectumFAP5.36e-20-4.37e-01-0.0272
55742PARVAA002-C-205HumanColorectumFAP1.09e-21-5.37e-01-0.1236
55742PARVAA014-C-108HumanColorectumFAP8.05e-03-3.99e-01-0.124
55742PARVAA001-C-104HumanColorectumFAP9.32e-10-4.00e-010.0184
55742PARVAA015-C-005HumanColorectumFAP7.34e-06-3.74e-01-0.0336
55742PARVAA015-C-006HumanColorectumFAP2.79e-16-6.01e-01-0.0994
55742PARVAA015-C-106HumanColorectumFAP1.27e-14-3.68e-01-0.0511
55742PARVAA002-C-114HumanColorectumFAP7.13e-18-5.24e-01-0.1561
55742PARVAA015-C-104HumanColorectumFAP2.38e-30-5.52e-01-0.1899
55742PARVAA001-C-014HumanColorectumFAP2.94e-20-4.75e-010.0135
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00316472ColorectumMSSregulation of protein stability103/3467298/187232.52e-113.49e-09103
GO:00226042ColorectumMSSregulation of cell morphogenesis103/3467309/187232.70e-102.56e-08103
GO:00508212ColorectumMSSprotein stabilization68/3467191/187231.53e-088.81e-0768
GO:00071632ColorectumMSSestablishment or maintenance of cell polarity72/3467218/187231.90e-078.30e-0672
GO:00315322ColorectumMSSactin cytoskeleton reorganization41/3467107/187231.21e-064.06e-0541
GO:00315892ColorectumMSScell-substrate adhesion104/3467363/187231.35e-064.51e-05104
GO:00083602ColorectumMSSregulation of cell shape52/3467154/187234.40e-061.24e-0452
GO:00300482ColorectumMSSactin filament-based movement44/3467127/187231.11e-052.64e-0444
GO:00344462ColorectumMSSsubstrate adhesion-dependent cell spreading39/3467108/187231.15e-052.71e-0439
GO:0070252ColorectumMSSactin-mediated cell contraction29/346797/187234.38e-033.10e-0229
GO:00226044ColorectumFAPregulation of cell morphogenesis87/2622309/187234.89e-111.87e-0887
GO:00315893ColorectumFAPcell-substrate adhesion93/2622363/187232.48e-094.61e-0793
GO:00071633ColorectumFAPestablishment or maintenance of cell polarity64/2622218/187232.83e-095.07e-0764
GO:00300483ColorectumFAPactin filament-based movement44/2622127/187233.48e-095.93e-0744
GO:00315323ColorectumFAPactin cytoskeleton reorganization34/2622107/187231.99e-068.03e-0534
GO:00508214ColorectumFAPprotein stabilization51/2622191/187232.63e-069.96e-0551
GO:00083603ColorectumFAPregulation of cell shape43/2622154/187234.55e-061.52e-0443
GO:00316474ColorectumFAPregulation of protein stability70/2622298/187236.60e-062.04e-0470
GO:00702521ColorectumFAPactin-mediated cell contraction28/262297/187231.06e-041.76e-0328
GO:00344464ColorectumFAPsubstrate adhesion-dependent cell spreading30/2622108/187231.32e-042.12e-0330
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa045102ColorectumFAPFocal adhesion61/1404203/84651.03e-062.15e-051.31e-0561
hsa045103ColorectumFAPFocal adhesion61/1404203/84651.03e-062.15e-051.31e-0561
hsa045104ColorectumCRCFocal adhesion51/1091203/84651.29e-065.41e-053.66e-0551
hsa045105ColorectumCRCFocal adhesion51/1091203/84651.29e-065.41e-053.66e-0551
hsa0451020EsophagusESCCFocal adhesion127/4205203/84651.25e-044.99e-042.56e-04127
hsa04510111EsophagusESCCFocal adhesion127/4205203/84651.25e-044.99e-042.56e-04127
hsa0451021LiverCirrhoticFocal adhesion93/2530203/84659.27e-071.10e-056.80e-0693
hsa0451031LiverCirrhoticFocal adhesion93/2530203/84659.27e-071.10e-056.80e-0693
hsa0451041LiverHCCFocal adhesion125/4020203/84653.12e-051.88e-041.04e-04125
hsa0451051LiverHCCFocal adhesion125/4020203/84653.12e-051.88e-041.04e-04125
hsa0451019Oral cavityOSCCFocal adhesion128/3704203/84651.71e-081.63e-078.31e-08128
hsa04510110Oral cavityOSCCFocal adhesion128/3704203/84651.71e-081.63e-078.31e-08128
hsa0451043Oral cavityNEOLPFocal adhesion71/1112203/84657.25e-167.68e-144.83e-1471
hsa0451053Oral cavityNEOLPFocal adhesion71/1112203/84657.25e-167.68e-144.83e-1471
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PARVASNVMissense_Mutationrs138341373c.331G>Ap.Glu111Lysp.E111Kprotein_codingtolerated(0.12)probably_damaging(0.997)TCGA-A8-A0A9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
PARVASNVMissense_Mutationnovelc.43N>Gp.Gln15Glup.Q15Eprotein_codingbenign(0.095)TCGA-UC-A7PG-06Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinPD
PARVASNVMissense_Mutationnovelc.236N>Ap.Arg79Glnp.R79Qprotein_codingdeleterious(0.01)possibly_damaging(0.897)TCGA-A6-5659-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
PARVASNVMissense_Mutationc.917A>Gp.Lys306Argp.K306Rprotein_codingtolerated(0.27)benign(0.027)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
PARVASNVMissense_Mutationc.731N>Ap.Pro244Glnp.P244Qprotein_codingdeleterious(0.03)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
PARVASNVMissense_Mutationnovelc.793N>Ap.Leu265Ilep.L265Iprotein_codingdeleterious(0.03)probably_damaging(0.997)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
PARVASNVMissense_Mutationnovelc.1126G>Tp.Asp376Tyrp.D376Yprotein_codingdeleterious(0)probably_damaging(1)TCGA-AJ-A5DW-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PARVASNVMissense_Mutationnovelc.395N>Ap.Pro132Hisp.P132Hprotein_codingdeleterious(0)possibly_damaging(0.525)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PARVASNVMissense_Mutationnovelc.287N>Tp.Ala96Valp.A96Vprotein_codingdeleterious(0)possibly_damaging(0.898)TCGA-B5-A3FC-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
PARVASNVMissense_Mutationnovelc.432N>Tp.Trp144Cysp.W144Cprotein_codingdeleterious(0)probably_damaging(0.959)TCGA-BG-A222-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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