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Gene: PARP11 |
Gene summary for PARP11 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PARP11 | Gene ID | 57097 |
| Gene name | poly(ADP-ribose) polymerase family member 11 | |
| Gene Alias | ARTD11 | |
| Cytomap | 12p13.32 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NR21 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57097 | PARP11 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 9.89e-02 | 0.0596 |
| 57097 | PARP11 | P2T-E | Human | Esophagus | ESCC | 5.95e-29 | 5.11e-01 | 0.1177 |
| 57097 | PARP11 | P4T-E | Human | Esophagus | ESCC | 8.33e-13 | 3.00e-01 | 0.1323 |
| 57097 | PARP11 | P8T-E | Human | Esophagus | ESCC | 1.46e-07 | 1.89e-01 | 0.0889 |
| 57097 | PARP11 | P10T-E | Human | Esophagus | ESCC | 3.19e-11 | 2.51e-01 | 0.116 |
| 57097 | PARP11 | P11T-E | Human | Esophagus | ESCC | 9.07e-04 | 1.56e-01 | 0.1426 |
| 57097 | PARP11 | P12T-E | Human | Esophagus | ESCC | 1.10e-20 | 3.85e-01 | 0.1122 |
| 57097 | PARP11 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 9.50e-02 | 0.1149 |
| 57097 | PARP11 | P20T-E | Human | Esophagus | ESCC | 3.11e-04 | 9.89e-02 | 0.1124 |
| 57097 | PARP11 | P22T-E | Human | Esophagus | ESCC | 4.13e-14 | 2.77e-01 | 0.1236 |
| 57097 | PARP11 | P24T-E | Human | Esophagus | ESCC | 7.96e-04 | 8.73e-02 | 0.1287 |
| 57097 | PARP11 | P26T-E | Human | Esophagus | ESCC | 1.07e-04 | 1.86e-01 | 0.1276 |
| 57097 | PARP11 | P27T-E | Human | Esophagus | ESCC | 4.63e-07 | 2.13e-01 | 0.1055 |
| 57097 | PARP11 | P30T-E | Human | Esophagus | ESCC | 4.84e-02 | 1.11e-01 | 0.137 |
| 57097 | PARP11 | P31T-E | Human | Esophagus | ESCC | 1.39e-06 | 1.14e-01 | 0.1251 |
| 57097 | PARP11 | P36T-E | Human | Esophagus | ESCC | 5.72e-04 | 1.27e-01 | 0.1187 |
| 57097 | PARP11 | P37T-E | Human | Esophagus | ESCC | 1.83e-06 | 1.27e-01 | 0.1371 |
| 57097 | PARP11 | P47T-E | Human | Esophagus | ESCC | 5.99e-04 | 8.15e-02 | 0.1067 |
| 57097 | PARP11 | P49T-E | Human | Esophagus | ESCC | 4.64e-06 | 3.83e-01 | 0.1768 |
| 57097 | PARP11 | P52T-E | Human | Esophagus | ESCC | 2.16e-06 | 1.65e-01 | 0.1555 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
| GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
| GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
| GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
| GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
| GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
| GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
| GO:000699811 | Esophagus | ESCC | nuclear envelope organization | 39/8552 | 47/18723 | 1.48e-07 | 2.35e-06 | 39 |
| GO:00702131 | Esophagus | ESCC | protein auto-ADP-ribosylation | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
| GO:0006471 | Esophagus | ESCC | protein ADP-ribosylation | 24/8552 | 35/18723 | 5.25e-03 | 1.97e-02 | 24 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PARP11 | SNV | Missense_Mutation | c.479C>T | p.Thr160Met | p.T160M | Q9NR21 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| PARP11 | insertion | In_Frame_Ins | novel | c.392_393insGGGCATCTCAGGCATCAGGGGCAG | p.Asn131delinsLysGlyIleSerGlyIleArgGlySer | p.N131delinsKGISGIRGS | Q9NR21 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
| PARP11 | SNV | Missense_Mutation | rs774543070 | c.560N>G | p.Gln187Arg | p.Q187R | Q9NR21 | protein_coding | deleterious(0.04) | possibly_damaging(0.806) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| PARP11 | SNV | Missense_Mutation | c.479N>T | p.Thr160Met | p.T160M | Q9NR21 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PARP11 | SNV | Missense_Mutation | rs762146923 | c.494N>A | p.Arg165Gln | p.R165Q | Q9NR21 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PARP11 | SNV | Missense_Mutation | novel | c.142N>C | p.Phe48Leu | p.F48L | Q9NR21 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PARP11 | SNV | Missense_Mutation | novel | c.860N>C | p.Tyr287Ser | p.Y287S | Q9NR21 | protein_coding | tolerated(0.22) | probably_damaging(0.997) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
| PARP11 | SNV | Missense_Mutation | c.227N>A | p.Ser76Tyr | p.S76Y | Q9NR21 | protein_coding | deleterious(0.02) | benign(0.349) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
| PARP11 | SNV | Missense_Mutation | c.905N>A | p.Gly302Glu | p.G302E | Q9NR21 | protein_coding | tolerated(0.14) | possibly_damaging(0.768) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
| PARP11 | SNV | Missense_Mutation | c.119N>A | p.Ala40Glu | p.A40E | Q9NR21 | protein_coding | tolerated(1) | benign(0.12) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 57097 | PARP11 | DRUGGABLE GENOME | antidepressants |
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