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Gene: PARD3B |
Gene summary for PARD3B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PARD3B | Gene ID | 117583 |
| Gene name | par-3 family cell polarity regulator beta | |
| Gene Alias | ALS2CR19 | |
| Cytomap | 2q33.3 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TEW8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 117583 | PARD3B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.88e-55 | -7.90e-01 | 0.0155 |
| 117583 | PARD3B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.24e-05 | -5.67e-01 | 0.0216 |
| 117583 | PARD3B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.37e-19 | -6.39e-01 | -0.1207 |
| 117583 | PARD3B | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.70e-03 | -3.74e-01 | -0.2061 |
| 117583 | PARD3B | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.47e-08 | -6.37e-01 | -0.1462 |
| 117583 | PARD3B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.34e-02 | -4.31e-01 | -0.0842 |
| 117583 | PARD3B | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.84e-03 | -4.76e-01 | -0.00410000000000005 |
| 117583 | PARD3B | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.48e-03 | -3.32e-01 | -0.0179 |
| 117583 | PARD3B | HTA11_866_3004761011 | Human | Colorectum | AD | 8.54e-33 | -7.06e-01 | 0.096 |
| 117583 | PARD3B | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.22e-05 | -7.23e-01 | 0.0451 |
| 117583 | PARD3B | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.33e-23 | -8.95e-01 | 0.0528 |
| 117583 | PARD3B | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.62e-03 | -4.39e-01 | -0.0177 |
| 117583 | PARD3B | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.94e-02 | -3.18e-01 | 0.0338 |
| 117583 | PARD3B | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.28e-04 | -4.53e-01 | 0.0112 |
| 117583 | PARD3B | HTA11_11156_2000001011 | Human | Colorectum | AD | 6.22e-04 | -4.94e-01 | 0.0397 |
| 117583 | PARD3B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.65e-27 | -5.87e-01 | 0.294 |
| 117583 | PARD3B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.41e-06 | -4.50e-01 | 0.281 |
| 117583 | PARD3B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.07e-12 | -5.03e-01 | 0.3859 |
| 117583 | PARD3B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.60e-13 | -5.09e-01 | 0.3005 |
| 117583 | PARD3B | A001-C-207 | Human | Colorectum | FAP | 1.82e-03 | -3.00e-01 | 0.1278 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
| GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
| GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
| GO:0045197 | Colorectum | AD | establishment or maintenance of epithelial cell apical/basal polarity | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
| GO:0035088 | Colorectum | AD | establishment or maintenance of apical/basal cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
| GO:0061245 | Colorectum | AD | establishment or maintenance of bipolar cell polarity | 21/3918 | 49/18723 | 4.31e-04 | 4.82e-03 | 21 |
| GO:0051660 | Colorectum | AD | establishment of centrosome localization | 7/3918 | 10/18723 | 1.15e-03 | 1.04e-02 | 7 |
| GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
| GO:00071631 | Colorectum | SER | establishment or maintenance of cell polarity | 60/2897 | 218/18723 | 3.45e-06 | 1.33e-04 | 60 |
| GO:00451971 | Colorectum | SER | establishment or maintenance of epithelial cell apical/basal polarity | 16/2897 | 44/18723 | 5.64e-04 | 7.83e-03 | 16 |
| GO:00350881 | Colorectum | SER | establishment or maintenance of apical/basal cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
| GO:00612451 | Colorectum | SER | establishment or maintenance of bipolar cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
| GO:00300101 | Colorectum | SER | establishment of cell polarity | 37/2897 | 143/18723 | 8.72e-04 | 1.06e-02 | 37 |
| GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
| GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
| GO:00300102 | Colorectum | MSS | establishment of cell polarity | 47/3467 | 143/18723 | 2.74e-05 | 5.58e-04 | 47 |
| GO:00451972 | Colorectum | MSS | establishment or maintenance of epithelial cell apical/basal polarity | 19/3467 | 44/18723 | 1.38e-04 | 2.06e-03 | 19 |
| GO:00350882 | Colorectum | MSS | establishment or maintenance of apical/basal cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
| GO:00612452 | Colorectum | MSS | establishment or maintenance of bipolar cell polarity | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
| GO:00516601 | Colorectum | MSS | establishment of centrosome localization | 7/3467 | 10/18723 | 5.26e-04 | 5.99e-03 | 7 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PARD3B | SNV | Missense_Mutation | novel | c.992N>G | p.Ala331Gly | p.A331G | Q8TEW8 | protein_coding | tolerated(0.23) | benign(0.114) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
| PARD3B | SNV | Missense_Mutation | rs757121760 | c.2404N>C | p.Asp802His | p.D802H | Q8TEW8 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| PARD3B | SNV | Missense_Mutation | novel | c.1316N>A | p.Arg439Lys | p.R439K | Q8TEW8 | protein_coding | tolerated(0.26) | probably_damaging(0.985) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PARD3B | SNV | Missense_Mutation | novel | c.2244G>C | p.Glu748Asp | p.E748D | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| PARD3B | deletion | Frame_Shift_Del | c.1570_1577delNNNNNNNN | p.Leu525PhefsTer13 | p.L525Ffs*13 | Q8TEW8 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| PARD3B | SNV | Missense_Mutation | novel | c.2668N>A | p.Glu890Lys | p.E890K | Q8TEW8 | protein_coding | tolerated(0.37) | benign(0.039) | TCGA-C5-A3HD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| PARD3B | SNV | Missense_Mutation | c.2335N>A | p.Glu779Lys | p.E779K | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| PARD3B | SNV | Missense_Mutation | novel | c.2643N>T | p.Lys881Asn | p.K881N | Q8TEW8 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| PARD3B | SNV | Missense_Mutation | novel | c.1441N>A | p.Glu481Lys | p.E481K | Q8TEW8 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| PARD3B | SNV | Missense_Mutation | c.917N>G | p.Ile306Ser | p.I306S | Q8TEW8 | protein_coding | tolerated(0.6) | benign(0.018) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 117583 | PARD3B | NA | oxaliplatin | OXALIPLATIN | 22310351 | |
| 117583 | PARD3B | NA | fluorouracil | FLUOROURACIL | 22310351 |
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