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Gene: PAQR5 |
Gene summary for PAQR5 |
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Gene information | Species | Human | Gene symbol | PAQR5 | Gene ID | 54852 |
Gene name | progestin and adipoQ receptor family member 5 | |
Gene Alias | MPRG | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R607 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54852 | PAQR5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.12e-07 | -3.98e-01 | 0.0155 |
54852 | PAQR5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.36e-06 | 4.31e-01 | -0.1954 |
54852 | PAQR5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.16e-07 | -4.27e-01 | 0.096 |
54852 | PAQR5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.54e-02 | -3.97e-01 | 0.0338 |
54852 | PAQR5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.61e-13 | -3.85e-01 | 0.0674 |
54852 | PAQR5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.88e-02 | -4.45e-01 | 0.0588 |
54852 | PAQR5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.99e-18 | -4.43e-01 | 0.294 |
54852 | PAQR5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.60e-19 | -4.61e-01 | 0.3859 |
54852 | PAQR5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.76e-19 | -4.60e-01 | 0.3005 |
54852 | PAQR5 | F007 | Human | Colorectum | FAP | 8.90e-09 | -5.05e-01 | 0.1176 |
54852 | PAQR5 | A002-C-010 | Human | Colorectum | FAP | 2.69e-16 | -4.22e-01 | 0.242 |
54852 | PAQR5 | A001-C-207 | Human | Colorectum | FAP | 2.28e-10 | -4.72e-01 | 0.1278 |
54852 | PAQR5 | A015-C-203 | Human | Colorectum | FAP | 9.73e-30 | -5.06e-01 | -0.1294 |
54852 | PAQR5 | A015-C-204 | Human | Colorectum | FAP | 1.61e-12 | -5.06e-01 | -0.0228 |
54852 | PAQR5 | A014-C-040 | Human | Colorectum | FAP | 3.02e-02 | -3.47e-01 | -0.1184 |
54852 | PAQR5 | A002-C-201 | Human | Colorectum | FAP | 1.55e-16 | -4.80e-01 | 0.0324 |
54852 | PAQR5 | A002-C-203 | Human | Colorectum | FAP | 7.35e-21 | -5.00e-01 | 0.2786 |
54852 | PAQR5 | A001-C-119 | Human | Colorectum | FAP | 5.55e-09 | -4.70e-01 | -0.1557 |
54852 | PAQR5 | A001-C-108 | Human | Colorectum | FAP | 7.22e-29 | -4.84e-01 | -0.0272 |
54852 | PAQR5 | A002-C-021 | Human | Colorectum | FAP | 1.53e-05 | -3.00e-01 | 0.1171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAQR5 | SNV | Missense_Mutation | c.47N>G | p.Pro16Arg | p.P16R | Q9NXK6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
PAQR5 | SNV | Missense_Mutation | c.430A>G | p.Met144Val | p.M144V | Q9NXK6 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAQR5 | SNV | Missense_Mutation | novel | c.601N>G | p.Phe201Val | p.F201V | Q9NXK6 | protein_coding | tolerated(0.07) | benign(0.144) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PAQR5 | SNV | Missense_Mutation | rs770284774 | c.413N>T | p.Thr138Met | p.T138M | Q9NXK6 | protein_coding | tolerated(0.05) | possibly_damaging(0.667) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PAQR5 | SNV | Missense_Mutation | c.301N>A | p.Ala101Thr | p.A101T | Q9NXK6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAQR5 | SNV | Missense_Mutation | novel | c.224N>G | p.Ile75Ser | p.I75S | Q9NXK6 | protein_coding | tolerated(0.21) | benign(0.015) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAQR5 | SNV | Missense_Mutation | c.73C>A | p.Leu25Met | p.L25M | Q9NXK6 | protein_coding | tolerated(0.39) | benign(0.196) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAQR5 | SNV | Missense_Mutation | c.183N>A | p.Phe61Leu | p.F61L | Q9NXK6 | protein_coding | deleterious(0) | benign(0.232) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PAQR5 | SNV | Missense_Mutation | c.332N>T | p.Ala111Val | p.A111V | Q9NXK6 | protein_coding | deleterious(0.05) | probably_damaging(0.951) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAQR5 | SNV | Missense_Mutation | novel | c.491N>T | p.Thr164Ile | p.T164I | Q9NXK6 | protein_coding | deleterious(0.03) | benign(0.35) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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