Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: PAPOLA

Gene summary for PAPOLA

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PAPOLA

Gene ID

10914

Gene namepoly(A) polymerase alpha
Gene AliasPAP
Cytomap14q32.2
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

P51003


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10914PAPOLAHTA11_3410_2000001011HumanColorectumAD1.33e-18-5.39e-010.0155
10914PAPOLAHTA11_696_2000001011HumanColorectumAD6.60e-04-3.40e-01-0.1464
10914PAPOLAHTA11_866_2000001011HumanColorectumAD1.47e-03-3.41e-01-0.1001
10914PAPOLAHTA11_546_2000001011HumanColorectumAD2.06e-03-3.92e-01-0.0842
10914PAPOLAHTA11_9341_2000001011HumanColorectumSER4.59e-04-7.52e-01-0.00410000000000005
10914PAPOLAHTA11_10711_2000001011HumanColorectumAD4.61e-03-4.07e-010.0338
10914PAPOLAHTA11_7696_3000711011HumanColorectumAD1.59e-05-3.75e-010.0674
10914PAPOLAHTA11_99999971662_82457HumanColorectumMSS7.81e-04-3.08e-010.3859
10914PAPOLAHTA11_99999974143_84620HumanColorectumMSS1.35e-06-3.91e-010.3005
10914PAPOLAF007HumanColorectumFAP9.66e-05-1.99e-010.1176
10914PAPOLAA001-C-207HumanColorectumFAP8.83e-07-2.64e-010.1278
10914PAPOLAA015-C-203HumanColorectumFAP5.18e-30-3.31e-01-0.1294
10914PAPOLAA015-C-204HumanColorectumFAP1.30e-10-2.44e-01-0.0228
10914PAPOLAA014-C-040HumanColorectumFAP8.18e-06-4.07e-01-0.1184
10914PAPOLAA002-C-201HumanColorectumFAP2.02e-18-3.57e-010.0324
10914PAPOLAA002-C-203HumanColorectumFAP4.32e-04-1.53e-010.2786
10914PAPOLAA001-C-119HumanColorectumFAP1.41e-11-4.38e-01-0.1557
10914PAPOLAA001-C-108HumanColorectumFAP2.17e-21-3.35e-01-0.0272
10914PAPOLAA002-C-205HumanColorectumFAP1.60e-27-4.00e-01-0.1236
10914PAPOLAA001-C-104HumanColorectumFAP2.66e-05-2.26e-010.0184
Page: 1 2 3 4 5 6 7 8 9 10 11 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:1903311ColorectumADregulation of mRNA metabolic process117/3918288/187231.69e-144.23e-12117
GO:0050684ColorectumADregulation of mRNA processing61/3918137/187234.23e-103.58e-0861
GO:19033111ColorectumSERregulation of mRNA metabolic process78/2897288/187232.61e-071.43e-0578
GO:00506841ColorectumSERregulation of mRNA processing42/2897137/187235.57e-062.01e-0442
GO:19033112ColorectumMSSregulation of mRNA metabolic process115/3467288/187231.23e-176.41e-15115
GO:00506842ColorectumMSSregulation of mRNA processing57/3467137/187232.88e-102.68e-0857
GO:19033114ColorectumFAPregulation of mRNA metabolic process97/2622288/187231.35e-174.13e-1497
GO:00506844ColorectumFAPregulation of mRNA processing51/2622137/187239.70e-124.96e-0951
GO:19033115ColorectumCRCregulation of mRNA metabolic process80/2078288/187233.21e-156.40e-1280
GO:00506845ColorectumCRCregulation of mRNA processing41/2078137/187231.57e-095.23e-0741
GO:190331110EndometriumAEHregulation of mRNA metabolic process77/2100288/187231.69e-134.40e-1177
GO:005068410EndometriumAEHregulation of mRNA processing42/2100137/187236.05e-105.67e-0842
GO:190331115EndometriumEECregulation of mRNA metabolic process79/2168288/187231.01e-132.64e-1179
GO:005068414EndometriumEECregulation of mRNA processing43/2168137/187234.52e-104.59e-0843
GO:1903311110EsophagusESCCregulation of mRNA metabolic process210/8552288/187233.25e-215.56e-19210
GO:0050684110EsophagusESCCregulation of mRNA processing109/8552137/187233.51e-162.59e-14109
GO:003112412EsophagusESCCmRNA 3'-end processing47/855262/187231.29e-061.58e-0547
GO:003144013EsophagusESCCregulation of mRNA 3'-end processing25/855228/187231.77e-062.10e-0525
GO:00311233EsophagusESCCRNA 3'-end processing76/8552116/187231.25e-051.15e-0476
GO:00063783EsophagusESCCmRNA polyadenylation33/855244/187237.30e-055.49e-0433
Page: 1 2 3 4 5 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa03015ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030151ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030152ColorectumFAPmRNA surveillance pathway26/140497/84657.11e-032.64e-021.60e-0226
hsa030153ColorectumFAPmRNA surveillance pathway26/140497/84657.11e-032.64e-021.60e-0226
hsa0301524EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa0301534EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa030154LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301511LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301521LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa0301531LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa030158Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301513Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301523Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa0301533Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa0301541Oral cavityEOLPmRNA surveillance pathway30/121897/84652.26e-051.20e-047.07e-0530
hsa0301551Oral cavityEOLPmRNA surveillance pathway30/121897/84652.26e-051.20e-047.07e-0530
hsa030156Oral cavityNEOLPmRNA surveillance pathway25/111297/84655.70e-043.18e-032.00e-0325
hsa030157Oral cavityNEOLPmRNA surveillance pathway25/111297/84655.70e-043.18e-032.00e-0325
hsa030155ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
hsa0301512ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
Page: 1 2 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PAPOLASNVMissense_Mutationc.554N>Tp.Arg185Leup.R185LP51003protein_codingdeleterious(0.05)benign(0.037)TCGA-A8-A097-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
PAPOLASNVMissense_Mutationc.1099T>Ap.Phe367Ilep.F367IP51003protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PAPOLASNVMissense_Mutationc.377N>Ap.Arg126Glnp.R126QP51003protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PAPOLASNVMissense_Mutationnovelc.1101N>Ap.Phe367Leup.F367LP51003protein_codingdeleterious(0.01)probably_damaging(0.995)TCGA-BH-A1FC-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PAPOLAinsertionFrame_Shift_Insnovelc.321_322insGAGCp.His108GlufsTer7p.H108Efs*7P51003protein_codingTCGA-A8-A07P-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilSD
PAPOLAinsertionFrame_Shift_Insnovelc.323_324insCCGTACCTGGCTGAAAACTTTTATTTTCp.Thr109ArgfsTer14p.T109Rfs*14P51003protein_codingTCGA-A8-A07P-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilSD
PAPOLAinsertionFrame_Shift_Insnovelc.662_663insATTCACAp.Leu222PhefsTer52p.L222Ffs*52P51003protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PAPOLAdeletionFrame_Shift_Delnovelc.1727delNp.Ser577LeufsTer5p.S577Lfs*5P51003protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
PAPOLASNVMissense_Mutationnovelc.1886N>Tp.Ser629Leup.S629LP51003protein_codingtolerated(0.22)unknown(0)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
PAPOLAinsertionIn_Frame_Insnovelc.2142_2142+1insAAAACATCCAGTACAGACCTTTCTGATATCCCTGCTCTCCCTp.Lys715_Pro728dupp.K715_P728dupP51003protein_codingTCGA-JW-A5VK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
10914PAPOLANAETOPOSIDEETOPOSIDE15503822
Page: 1