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Gene: PAPLN |
Gene summary for PAPLN |
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Gene information | Species | Human | Gene symbol | PAPLN | Gene ID | 89932 |
Gene name | papilin, proteoglycan like sulfated glycoprotein | |
Gene Alias | PPN | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B3KXI1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89932 | PAPLN | male-WTA | Human | Thyroid | PTC | 1.21e-24 | 2.92e-01 | 0.1037 |
89932 | PAPLN | PTC01 | Human | Thyroid | PTC | 1.24e-09 | 1.93e-01 | 0.1899 |
89932 | PAPLN | PTC04 | Human | Thyroid | PTC | 1.50e-26 | 5.35e-01 | 0.1927 |
89932 | PAPLN | PTC05 | Human | Thyroid | PTC | 3.01e-16 | 5.63e-01 | 0.2065 |
89932 | PAPLN | PTC06 | Human | Thyroid | PTC | 5.23e-29 | 6.59e-01 | 0.2057 |
89932 | PAPLN | PTC07 | Human | Thyroid | PTC | 9.63e-25 | 3.54e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0052547113 | Thyroid | PTC | regulation of peptidase activity | 191/5968 | 461/18723 | 7.82e-06 | 9.02e-05 | 191 |
GO:0052548113 | Thyroid | PTC | regulation of endopeptidase activity | 174/5968 | 432/18723 | 1.20e-04 | 9.55e-04 | 174 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:0051346112 | Thyroid | PTC | negative regulation of hydrolase activity | 146/5968 | 379/18723 | 3.33e-03 | 1.62e-02 | 146 |
GO:0045861113 | Thyroid | PTC | negative regulation of proteolysis | 136/5968 | 351/18723 | 3.54e-03 | 1.71e-02 | 136 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAPLN | SNV | Missense_Mutation | c.2341N>T | p.Leu781Phe | p.L781F | O95428 | protein_coding | tolerated(0.63) | benign(0.134) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PAPLN | SNV | Missense_Mutation | novel | c.2161N>G | p.His721Asp | p.H721D | O95428 | protein_coding | deleterious(0.01) | benign(0.028) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PAPLN | SNV | Missense_Mutation | c.2417N>A | p.Ala806Glu | p.A806E | O95428 | protein_coding | tolerated(0.55) | benign(0.037) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PAPLN | SNV | Missense_Mutation | rs530218324 | c.1205N>T | p.Pro402Leu | p.P402L | O95428 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-EW-A6SB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PAPLN | SNV | Missense_Mutation | novel | c.1085N>A | p.Cys362Tyr | p.C362Y | O95428 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A3NY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PAPLN | SNV | Missense_Mutation | rs777386780 | c.1105G>A | p.Gly369Ser | p.G369S | O95428 | protein_coding | tolerated(0.38) | benign(0.351) | TCGA-OL-A66K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAPLN | insertion | Frame_Shift_Ins | novel | c.3359_3360insGGCTCACGCC | p.Asp1121AlafsTer4 | p.D1121Afs*4 | O95428 | protein_coding | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
PAPLN | deletion | Frame_Shift_Del | novel | c.1493delN | p.Lys499SerfsTer276 | p.K499Sfs*276 | O95428 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PAPLN | SNV | Missense_Mutation | rs374521670 | c.688N>T | p.Arg230Trp | p.R230W | O95428 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAPLN | SNV | Missense_Mutation | novel | c.1907N>G | p.Tyr636Cys | p.Y636C | O95428 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
89932 | PAPLN | PROTEASE INHIBITOR | citalopram | CITALOPRAM |
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