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Gene: PAPD5 |
Gene summary for PAPD5 |
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Gene information | Species | Human | Gene symbol | PAPD5 | Gene ID | 64282 |
Gene name | terminal nucleotidyltransferase 4B | |
Gene Alias | PAPD5 | |
Cytomap | 16q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q8NDF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64282 | PAPD5 | P2T-E | Human | Esophagus | ESCC | 1.33e-10 | 3.75e-02 | 0.1177 |
64282 | PAPD5 | P4T-E | Human | Esophagus | ESCC | 2.64e-15 | 2.27e-01 | 0.1323 |
64282 | PAPD5 | P5T-E | Human | Esophagus | ESCC | 4.73e-10 | 9.09e-02 | 0.1327 |
64282 | PAPD5 | P8T-E | Human | Esophagus | ESCC | 5.66e-06 | 1.22e-01 | 0.0889 |
64282 | PAPD5 | P10T-E | Human | Esophagus | ESCC | 1.00e-14 | 9.54e-02 | 0.116 |
64282 | PAPD5 | P11T-E | Human | Esophagus | ESCC | 1.16e-09 | 3.03e-01 | 0.1426 |
64282 | PAPD5 | P12T-E | Human | Esophagus | ESCC | 3.38e-13 | 1.07e-01 | 0.1122 |
64282 | PAPD5 | P15T-E | Human | Esophagus | ESCC | 3.99e-09 | 7.94e-02 | 0.1149 |
64282 | PAPD5 | P16T-E | Human | Esophagus | ESCC | 7.86e-14 | 5.81e-02 | 0.1153 |
64282 | PAPD5 | P20T-E | Human | Esophagus | ESCC | 3.54e-08 | 1.08e-01 | 0.1124 |
64282 | PAPD5 | P21T-E | Human | Esophagus | ESCC | 4.65e-13 | 1.51e-01 | 0.1617 |
64282 | PAPD5 | P22T-E | Human | Esophagus | ESCC | 1.68e-08 | 7.32e-02 | 0.1236 |
64282 | PAPD5 | P23T-E | Human | Esophagus | ESCC | 6.92e-05 | 5.84e-02 | 0.108 |
64282 | PAPD5 | P26T-E | Human | Esophagus | ESCC | 8.17e-15 | 2.56e-01 | 0.1276 |
64282 | PAPD5 | P27T-E | Human | Esophagus | ESCC | 3.23e-09 | 6.22e-02 | 0.1055 |
64282 | PAPD5 | P28T-E | Human | Esophagus | ESCC | 1.76e-15 | 2.45e-01 | 0.1149 |
64282 | PAPD5 | P30T-E | Human | Esophagus | ESCC | 4.04e-10 | 4.57e-01 | 0.137 |
64282 | PAPD5 | P31T-E | Human | Esophagus | ESCC | 4.56e-08 | 1.33e-01 | 0.1251 |
64282 | PAPD5 | P32T-E | Human | Esophagus | ESCC | 8.90e-08 | 1.17e-01 | 0.1666 |
64282 | PAPD5 | P36T-E | Human | Esophagus | ESCC | 1.80e-06 | 1.05e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAPD5 | SNV | Missense_Mutation | novel | c.1736N>T | p.Gln579Leu | p.Q579L | Q8NDF8 | protein_coding | tolerated(0.24) | benign(0) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAPD5 | SNV | Missense_Mutation | c.1511G>A | p.Arg504Lys | p.R504K | Q8NDF8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PAPD5 | SNV | Missense_Mutation | c.1700N>G | p.Ser567Cys | p.S567C | Q8NDF8 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PAPD5 | SNV | Missense_Mutation | novel | c.1653N>C | p.Lys551Asn | p.K551N | Q8NDF8 | protein_coding | tolerated(0.19) | possibly_damaging(0.738) | TCGA-V7-A7HQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | letrozole | CR |
PAPD5 | insertion | Nonsense_Mutation | novel | c.1737_1738insCTTTGATA | p.Ser580LeufsTer2 | p.S580Lfs*2 | Q8NDF8 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PAPD5 | SNV | Missense_Mutation | novel | c.1718C>T | p.Ser573Leu | p.S573L | Q8NDF8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAPD5 | SNV | Missense_Mutation | c.1795N>A | p.Leu599Ile | p.L599I | Q8NDF8 | protein_coding | tolerated_low_confidence(0.41) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAPD5 | SNV | Missense_Mutation | c.1700N>T | p.Ser567Phe | p.S567F | Q8NDF8 | protein_coding | deleterious(0.04) | probably_damaging(0.942) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAPD5 | SNV | Missense_Mutation | c.652A>G | p.Lys218Glu | p.K218E | Q8NDF8 | protein_coding | tolerated(0.23) | benign(0.017) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAPD5 | SNV | Missense_Mutation | c.860N>T | p.Ser287Leu | p.S287L | Q8NDF8 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-AY-5543-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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