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Gene: PAF1 |
Gene summary for PAF1 |
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Gene information | Species | Human | Gene symbol | PAF1 | Gene ID | 54623 |
Gene name | PAF1 homolog, Paf1/RNA polymerase II complex component | |
Gene Alias | F23149_1 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8N7H5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54623 | PAF1 | LZE4T | Human | Esophagus | ESCC | 2.35e-10 | 2.85e-01 | 0.0811 |
54623 | PAF1 | LZE7T | Human | Esophagus | ESCC | 6.25e-07 | 4.52e-01 | 0.0667 |
54623 | PAF1 | LZE8T | Human | Esophagus | ESCC | 3.60e-14 | 2.37e-01 | 0.067 |
54623 | PAF1 | LZE20T | Human | Esophagus | ESCC | 4.50e-05 | -2.04e-02 | 0.0662 |
54623 | PAF1 | LZE22T | Human | Esophagus | ESCC | 5.57e-07 | 2.63e-01 | 0.068 |
54623 | PAF1 | LZE24T | Human | Esophagus | ESCC | 1.03e-17 | 5.06e-01 | 0.0596 |
54623 | PAF1 | LZE21T | Human | Esophagus | ESCC | 3.29e-05 | 1.87e-01 | 0.0655 |
54623 | PAF1 | LZE6T | Human | Esophagus | ESCC | 1.99e-10 | 2.19e-01 | 0.0845 |
54623 | PAF1 | P1T-E | Human | Esophagus | ESCC | 1.06e-11 | 9.73e-01 | 0.0875 |
54623 | PAF1 | P2T-E | Human | Esophagus | ESCC | 3.36e-25 | 5.34e-01 | 0.1177 |
54623 | PAF1 | P4T-E | Human | Esophagus | ESCC | 1.15e-21 | 5.15e-01 | 0.1323 |
54623 | PAF1 | P5T-E | Human | Esophagus | ESCC | 6.83e-13 | 1.96e-01 | 0.1327 |
54623 | PAF1 | P8T-E | Human | Esophagus | ESCC | 3.63e-33 | 8.67e-01 | 0.0889 |
54623 | PAF1 | P9T-E | Human | Esophagus | ESCC | 8.69e-19 | 6.26e-02 | 0.1131 |
54623 | PAF1 | P10T-E | Human | Esophagus | ESCC | 2.53e-27 | 4.87e-01 | 0.116 |
54623 | PAF1 | P11T-E | Human | Esophagus | ESCC | 4.35e-16 | 6.07e-01 | 0.1426 |
54623 | PAF1 | P12T-E | Human | Esophagus | ESCC | 2.92e-30 | 6.29e-01 | 0.1122 |
54623 | PAF1 | P15T-E | Human | Esophagus | ESCC | 2.61e-24 | 5.29e-01 | 0.1149 |
54623 | PAF1 | P16T-E | Human | Esophagus | ESCC | 8.13e-20 | 2.43e-01 | 0.1153 |
54623 | PAF1 | P17T-E | Human | Esophagus | ESCC | 5.58e-08 | 3.81e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:190331316 | Esophagus | ESCC | positive regulation of mRNA metabolic process | 87/8552 | 118/18723 | 5.10e-10 | 1.32e-08 | 87 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:001657414 | Esophagus | ESCC | histone ubiquitination | 40/8552 | 47/18723 | 2.40e-08 | 4.55e-07 | 40 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAF1 | SNV | Missense_Mutation | c.1067T>C | p.Met356Thr | p.M356T | Q8N7H5 | protein_coding | tolerated(0.11) | possibly_damaging(0.647) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
PAF1 | SNV | Missense_Mutation | c.79N>A | p.Ser27Thr | p.S27T | Q8N7H5 | protein_coding | tolerated(0.1) | benign(0.214) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PAF1 | SNV | Missense_Mutation | c.1099N>T | p.Arg367Trp | p.R367W | Q8N7H5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1BN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
PAF1 | SNV | Missense_Mutation | c.1234G>C | p.Glu412Gln | p.E412Q | Q8N7H5 | protein_coding | deleterious(0.05) | benign(0.105) | TCGA-DG-A2KH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PAF1 | SNV | Missense_Mutation | c.261N>G | p.Ile87Met | p.I87M | Q8N7H5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PAF1 | SNV | Missense_Mutation | c.499N>A | p.Glu167Lys | p.E167K | Q8N7H5 | protein_coding | tolerated(0.5) | benign(0.082) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
PAF1 | SNV | Missense_Mutation | c.1321N>C | p.Glu441Gln | p.E441Q | Q8N7H5 | protein_coding | deleterious(0.03) | possibly_damaging(0.856) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAF1 | SNV | Missense_Mutation | c.526N>C | p.Ile176Leu | p.I176L | Q8N7H5 | protein_coding | deleterious(0.04) | possibly_damaging(0.465) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAF1 | SNV | Missense_Mutation | c.931T>C | p.Tyr311His | p.Y311H | Q8N7H5 | protein_coding | tolerated(0.06) | possibly_damaging(0.76) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PAF1 | SNV | Missense_Mutation | novel | c.98N>C | p.Val33Ala | p.V33A | Q8N7H5 | protein_coding | deleterious(0) | possibly_damaging(0.726) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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