|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: PACSIN3 |
Gene summary for PACSIN3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PACSIN3 | Gene ID | 29763 |
| Gene name | protein kinase C and casein kinase substrate in neurons 3 | |
| Gene Alias | SDPIII | |
| Cytomap | 11p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UKS6 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 29763 | PACSIN3 | LZE4T | Human | Esophagus | ESCC | 1.12e-02 | 9.31e-02 | 0.0811 |
| 29763 | PACSIN3 | LZE7T | Human | Esophagus | ESCC | 6.51e-03 | 2.51e-01 | 0.0667 |
| 29763 | PACSIN3 | LZE8T | Human | Esophagus | ESCC | 6.63e-04 | 4.49e-02 | 0.067 |
| 29763 | PACSIN3 | LZE22T | Human | Esophagus | ESCC | 2.79e-02 | 1.81e-01 | 0.068 |
| 29763 | PACSIN3 | LZE24T | Human | Esophagus | ESCC | 6.28e-09 | 3.45e-01 | 0.0596 |
| 29763 | PACSIN3 | P1T-E | Human | Esophagus | ESCC | 1.97e-04 | 4.41e-01 | 0.0875 |
| 29763 | PACSIN3 | P2T-E | Human | Esophagus | ESCC | 1.41e-22 | 5.46e-01 | 0.1177 |
| 29763 | PACSIN3 | P4T-E | Human | Esophagus | ESCC | 2.83e-23 | 5.00e-01 | 0.1323 |
| 29763 | PACSIN3 | P5T-E | Human | Esophagus | ESCC | 4.39e-17 | 2.60e-01 | 0.1327 |
| 29763 | PACSIN3 | P8T-E | Human | Esophagus | ESCC | 2.57e-22 | 3.84e-01 | 0.0889 |
| 29763 | PACSIN3 | P9T-E | Human | Esophagus | ESCC | 4.09e-15 | 4.58e-01 | 0.1131 |
| 29763 | PACSIN3 | P10T-E | Human | Esophagus | ESCC | 3.89e-13 | 1.04e-01 | 0.116 |
| 29763 | PACSIN3 | P11T-E | Human | Esophagus | ESCC | 3.49e-14 | 6.27e-01 | 0.1426 |
| 29763 | PACSIN3 | P12T-E | Human | Esophagus | ESCC | 7.62e-20 | 3.95e-01 | 0.1122 |
| 29763 | PACSIN3 | P15T-E | Human | Esophagus | ESCC | 2.38e-17 | 4.13e-01 | 0.1149 |
| 29763 | PACSIN3 | P16T-E | Human | Esophagus | ESCC | 7.82e-24 | 3.74e-01 | 0.1153 |
| 29763 | PACSIN3 | P17T-E | Human | Esophagus | ESCC | 7.98e-15 | 5.69e-01 | 0.1278 |
| 29763 | PACSIN3 | P19T-E | Human | Esophagus | ESCC | 1.00e-04 | 6.91e-01 | 0.1662 |
| 29763 | PACSIN3 | P20T-E | Human | Esophagus | ESCC | 3.77e-19 | 4.52e-01 | 0.1124 |
| 29763 | PACSIN3 | P21T-E | Human | Esophagus | ESCC | 2.02e-36 | 7.97e-01 | 0.1617 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
| GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
| GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
| GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
| GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
| GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
| GO:00065095 | Esophagus | ESCC | membrane protein ectodomain proteolysis | 31/8552 | 43/18723 | 4.04e-04 | 2.30e-03 | 31 |
| GO:00336195 | Esophagus | ESCC | membrane protein proteolysis | 39/8552 | 57/18723 | 4.34e-04 | 2.44e-03 | 39 |
| GO:00510431 | Esophagus | ESCC | regulation of membrane protein ectodomain proteolysis | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
| GO:004217612 | Liver | Cirrhotic | regulation of protein catabolic process | 181/4634 | 391/18723 | 7.94e-21 | 2.77e-18 | 181 |
| GO:000989612 | Liver | Cirrhotic | positive regulation of catabolic process | 215/4634 | 492/18723 | 1.13e-20 | 3.56e-18 | 215 |
| GO:003133112 | Liver | Cirrhotic | positive regulation of cellular catabolic process | 190/4634 | 427/18723 | 1.94e-19 | 4.18e-17 | 190 |
| GO:004586212 | Liver | Cirrhotic | positive regulation of proteolysis | 163/4634 | 372/18723 | 4.18e-16 | 5.14e-14 | 163 |
| GO:004573212 | Liver | Cirrhotic | positive regulation of protein catabolic process | 112/4634 | 231/18723 | 3.89e-15 | 4.21e-13 | 112 |
| GO:00336192 | Liver | Cirrhotic | membrane protein proteolysis | 31/4634 | 57/18723 | 1.55e-06 | 3.02e-05 | 31 |
| GO:00065092 | Liver | Cirrhotic | membrane protein ectodomain proteolysis | 24/4634 | 43/18723 | 1.30e-05 | 1.82e-04 | 24 |
| GO:003010011 | Liver | Cirrhotic | regulation of endocytosis | 74/4634 | 211/18723 | 4.86e-04 | 3.90e-03 | 74 |
| GO:0051043 | Liver | Cirrhotic | regulation of membrane protein ectodomain proteolysis | 13/4634 | 24/18723 | 1.89e-03 | 1.19e-02 | 13 |
| GO:00510514 | Liver | Cirrhotic | negative regulation of transport | 141/4634 | 470/18723 | 5.06e-03 | 2.62e-02 | 141 |
| GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PACSIN3 | SNV | Missense_Mutation | c.663N>T | p.Met221Ile | p.M221I | Q9UKS6 | protein_coding | tolerated(0.15) | possibly_damaging(0.677) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
| PACSIN3 | SNV | Missense_Mutation | c.634N>A | p.Glu212Lys | p.E212K | Q9UKS6 | protein_coding | deleterious(0) | benign(0.341) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
| PACSIN3 | SNV | Missense_Mutation | rs763827628 | c.71G>A | p.Arg24His | p.R24H | Q9UKS6 | protein_coding | deleterious(0.01) | possibly_damaging(0.494) | TCGA-D8-A1XY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | tamoxiphen | SD |
| PACSIN3 | SNV | Missense_Mutation | novel | c.839N>G | p.Asp280Gly | p.D280G | Q9UKS6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-GM-A5PV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| PACSIN3 | SNV | Missense_Mutation | c.901G>A | p.Glu301Lys | p.E301K | Q9UKS6 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| PACSIN3 | SNV | Missense_Mutation | novel | c.1179G>C | p.Met393Ile | p.M393I | Q9UKS6 | protein_coding | tolerated(0.62) | benign(0.003) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| PACSIN3 | SNV | Missense_Mutation | c.1229G>A | p.Arg410His | p.R410H | Q9UKS6 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PACSIN3 | SNV | Missense_Mutation | rs199499148 | c.139N>A | p.Ala47Thr | p.A47T | Q9UKS6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| PACSIN3 | SNV | Missense_Mutation | c.1103T>C | p.Val368Ala | p.V368A | Q9UKS6 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| PACSIN3 | SNV | Missense_Mutation | c.1229N>A | p.Arg410His | p.R410H | Q9UKS6 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |