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Gene: PAAF1 |
Gene summary for PAAF1 |
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Gene information | Species | Human | Gene symbol | PAAF1 | Gene ID | 80227 |
Gene name | proteasomal ATPase associated factor 1 | |
Gene Alias | PAAF | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0000502 | UniProtAcc | A0A024R5N4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80227 | PAAF1 | LZE4T | Human | Esophagus | ESCC | 6.04e-05 | 7.89e-02 | 0.0811 |
80227 | PAAF1 | LZE7T | Human | Esophagus | ESCC | 1.15e-02 | 9.75e-02 | 0.0667 |
80227 | PAAF1 | LZE8T | Human | Esophagus | ESCC | 1.43e-05 | 1.25e-01 | 0.067 |
80227 | PAAF1 | LZE20T | Human | Esophagus | ESCC | 6.51e-05 | 1.34e-01 | 0.0662 |
80227 | PAAF1 | LZE22D1 | Human | Esophagus | HGIN | 1.28e-02 | 1.40e-01 | 0.0595 |
80227 | PAAF1 | LZE22T | Human | Esophagus | ESCC | 1.62e-02 | 2.66e-01 | 0.068 |
80227 | PAAF1 | LZE24T | Human | Esophagus | ESCC | 7.16e-09 | 2.30e-01 | 0.0596 |
80227 | PAAF1 | LZE6T | Human | Esophagus | ESCC | 3.45e-05 | 1.30e-01 | 0.0845 |
80227 | PAAF1 | P2T-E | Human | Esophagus | ESCC | 1.67e-51 | 8.98e-01 | 0.1177 |
80227 | PAAF1 | P4T-E | Human | Esophagus | ESCC | 2.12e-29 | 5.33e-01 | 0.1323 |
80227 | PAAF1 | P5T-E | Human | Esophagus | ESCC | 9.54e-12 | 1.20e-01 | 0.1327 |
80227 | PAAF1 | P8T-E | Human | Esophagus | ESCC | 1.00e-19 | 2.57e-01 | 0.0889 |
80227 | PAAF1 | P9T-E | Human | Esophagus | ESCC | 7.82e-10 | 1.60e-01 | 0.1131 |
80227 | PAAF1 | P10T-E | Human | Esophagus | ESCC | 4.68e-18 | 2.31e-01 | 0.116 |
80227 | PAAF1 | P11T-E | Human | Esophagus | ESCC | 1.01e-07 | 3.21e-01 | 0.1426 |
80227 | PAAF1 | P12T-E | Human | Esophagus | ESCC | 1.86e-23 | 4.08e-01 | 0.1122 |
80227 | PAAF1 | P15T-E | Human | Esophagus | ESCC | 1.44e-08 | 8.10e-02 | 0.1149 |
80227 | PAAF1 | P16T-E | Human | Esophagus | ESCC | 3.09e-17 | 2.80e-01 | 0.1153 |
80227 | PAAF1 | P17T-E | Human | Esophagus | ESCC | 8.48e-06 | 2.73e-01 | 0.1278 |
80227 | PAAF1 | P19T-E | Human | Esophagus | ESCC | 8.44e-05 | 3.63e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAAF1 | insertion | Frame_Shift_Ins | novel | c.277_278insG | p.Lys93ArgfsTer19 | p.K93Rfs*19 | Q9BRP4 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
PAAF1 | insertion | Frame_Shift_Ins | novel | c.280_281insATCATAGTTTTTGCTGTCTGTGA | p.Ser94AsnfsTer8 | p.S94Nfs*8 | Q9BRP4 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
PAAF1 | deletion | Frame_Shift_Del | c.907_910delNNNN | p.Tyr304SerfsTer4 | p.Y304Sfs*4 | Q9BRP4 | protein_coding | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |||
PAAF1 | SNV | Missense_Mutation | rs763363623 | c.734N>A | p.Arg245Gln | p.R245Q | Q9BRP4 | protein_coding | deleterious(0.01) | possibly_damaging(0.457) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAAF1 | SNV | Missense_Mutation | c.902G>A | p.Gly301Glu | p.G301E | Q9BRP4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
PAAF1 | SNV | Missense_Mutation | novel | c.781A>G | p.Lys261Glu | p.K261E | Q9BRP4 | protein_coding | tolerated(0.15) | benign(0.037) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PAAF1 | SNV | Missense_Mutation | c.386N>C | p.Val129Ala | p.V129A | Q9BRP4 | protein_coding | tolerated(0.75) | benign(0.011) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAAF1 | SNV | Missense_Mutation | rs771669139 | c.619C>T | p.Arg207Cys | p.R207C | Q9BRP4 | protein_coding | deleterious(0.01) | benign(0.353) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PAAF1 | SNV | Missense_Mutation | c.520N>T | p.Gly174Cys | p.G174C | Q9BRP4 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAAF1 | SNV | Missense_Mutation | novel | c.247C>T | p.Pro83Ser | p.P83S | Q9BRP4 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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