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Gene: OTOS |
Gene summary for OTOS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | OTOS | Gene ID | 150677 |
| Gene name | otospiralin | |
| Gene Alias | OTOSP | |
| Cytomap | 2q37.3 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8NHW6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 150677 | OTOS | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.58e-12 | -6.22e-01 | 0.02 |
| 150677 | OTOS | PTCwithHT_6 | Human | Thyroid | HT | 5.09e-09 | -6.19e-01 | 0.02 |
| 150677 | OTOS | PTCwithHT_8 | Human | Thyroid | HT | 1.22e-09 | -5.84e-01 | 0.0351 |
| 150677 | OTOS | PTCwithoutHT_2 | Human | Thyroid | PTC | 1.23e-17 | -6.44e-01 | 0.0419 |
| 150677 | OTOS | PTCwithoutHT_7 | Human | Thyroid | PTC | 4.22e-03 | -5.89e-01 | 0.0381 |
| 150677 | OTOS | male-WTA | Human | Thyroid | PTC | 1.25e-13 | -5.65e-01 | 0.1037 |
| 150677 | OTOS | female-WTA | Human | Thyroid | PTC | 1.41e-04 | -6.23e-01 | 0.0726 |
| 150677 | OTOS | PTC01 | Human | Thyroid | PTC | 1.05e-17 | -5.69e-01 | 0.1899 |
| 150677 | OTOS | PTC03 | Human | Thyroid | PTC | 1.65e-06 | -5.63e-01 | 0.1784 |
| 150677 | OTOS | PTC05 | Human | Thyroid | PTC | 4.16e-06 | -4.92e-01 | 0.2065 |
| 150677 | OTOS | PTC06 | Human | Thyroid | PTC | 8.44e-09 | -3.01e-01 | 0.2057 |
| 150677 | OTOS | PTC07 | Human | Thyroid | PTC | 1.52e-15 | -2.90e-01 | 0.2044 |
| 150677 | OTOS | ATC08 | Human | Thyroid | ATC | 9.11e-05 | -6.44e-01 | 0.0541 |
| 150677 | OTOS | ATC09 | Human | Thyroid | ATC | 1.24e-05 | -6.44e-01 | 0.2871 |
| 150677 | OTOS | ATC12 | Human | Thyroid | ATC | 6.38e-17 | -6.44e-01 | 0.34 |
| 150677 | OTOS | ATC13 | Human | Thyroid | ATC | 7.43e-16 | -6.43e-01 | 0.34 |
| 150677 | OTOS | ATC1 | Human | Thyroid | ATC | 2.06e-04 | -6.44e-01 | 0.2878 |
| 150677 | OTOS | ATC4 | Human | Thyroid | ATC | 1.62e-17 | -6.44e-01 | 0.34 |
| 150677 | OTOS | ATC5 | Human | Thyroid | ATC | 6.38e-17 | -6.43e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| OTOS | SNV | Missense_Mutation | novel | c.267C>G | p.Asp89Glu | p.D89E | Q8NHW6 | protein_coding | tolerated(0.61) | benign(0.012) | TCGA-A7-A5ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
| OTOS | SNV | Missense_Mutation | novel | c.103C>T | p.Pro35Ser | p.P35S | Q8NHW6 | protein_coding | tolerated(0.1) | probably_damaging(0.947) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| OTOS | SNV | Missense_Mutation | novel | c.107N>T | p.Ala36Val | p.A36V | Q8NHW6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| OTOS | SNV | Missense_Mutation | novel | c.28N>A | p.Ala10Thr | p.A10T | Q8NHW6 | protein_coding | tolerated(0.38) | possibly_damaging(0.765) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| OTOS | SNV | Missense_Mutation | c.199N>A | p.Ala67Thr | p.A67T | Q8NHW6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| OTOS | SNV | Missense_Mutation | novel | c.89N>A | p.Pro30His | p.P30H | Q8NHW6 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| OTOS | deletion | Frame_Shift_Del | c.184delN | p.Gln62ArgfsTer? | p.Q62Rfs*? | Q8NHW6 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| OTOS | deletion | Frame_Shift_Del | c.184delN | p.Gln62ArgfsTer? | p.Q62Rfs*? | Q8NHW6 | protein_coding | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
| OTOS | SNV | Missense_Mutation | novel | c.35N>T | p.Cys12Phe | p.C12F | Q8NHW6 | protein_coding | tolerated(0.15) | possibly_damaging(0.648) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| OTOS | SNV | Missense_Mutation | novel | c.242N>T | p.Gly81Val | p.G81V | Q8NHW6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 150677 | OTOS | DRUGGABLE GENOME | cisplatin | CISPLATIN | 25410892,31666714 |
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