Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: OSR2

Gene summary for OSR2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

OSR2

Gene ID

116039

Gene nameodd-skipped related transciption factor 2
Gene AliasOSR2
Cytomap8q22.2
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q8N2R0


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
116039OSR2AEH-subject1HumanEndometriumAEH9.80e-32-6.48e-01-0.3059
116039OSR2AEH-subject2HumanEndometriumAEH4.31e-25-6.14e-01-0.2525
116039OSR2AEH-subject3HumanEndometriumAEH2.47e-27-6.26e-01-0.2576
116039OSR2AEH-subject4HumanEndometriumAEH1.02e-15-5.75e-01-0.2657
116039OSR2AEH-subject5HumanEndometriumAEH2.10e-32-6.72e-01-0.2953
116039OSR2EEC-subject1HumanEndometriumEEC1.55e-31-6.58e-01-0.2682
116039OSR2EEC-subject2HumanEndometriumEEC9.75e-31-6.65e-01-0.2607
116039OSR2EEC-subject3HumanEndometriumEEC1.22e-35-6.51e-01-0.2525
116039OSR2EEC-subject4HumanEndometriumEEC4.33e-29-6.17e-01-0.2571
116039OSR2EEC-subject5HumanEndometriumEEC7.41e-35-6.72e-01-0.249
116039OSR2GSM5276934HumanEndometriumEEC3.33e-30-6.35e-01-0.0913
116039OSR2GSM5276935HumanEndometriumEEC5.94e-34-6.73e-01-0.123
116039OSR2GSM5276937HumanEndometriumEEC1.10e-20-5.97e-01-0.0897
116039OSR2GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC5.48e-25-6.26e-01-0.1869
116039OSR2GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC2.55e-28-6.83e-01-0.1875
116039OSR2GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC3.77e-28-6.35e-01-0.1883
116039OSR2GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC3.55e-35-6.74e-01-0.1934
116039OSR2GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC1.40e-37-6.73e-01-0.1917
116039OSR2GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC2.62e-39-6.70e-01-0.1916
116039OSR2GSM6177623_NYU_UCEC3_VisHumanEndometriumEEC2.81e-07-4.42e-01-0.1269
Page: 1 2 3 4 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00506738EndometriumAEHepithelial cell proliferation84/2100437/187234.88e-071.94e-0584
GO:00015038EndometriumAEHossification78/2100408/187231.54e-064.85e-0578
GO:00016556EndometriumAEHurogenital system development67/2100338/187232.30e-066.76e-0567
GO:00506788EndometriumAEHregulation of epithelial cell proliferation73/2100381/187233.04e-068.44e-0573
GO:00720015EndometriumAEHrenal system development61/2100302/187233.43e-069.24e-0561
GO:00018224EndometriumAEHkidney development57/2100293/187232.25e-054.35e-0457
GO:00506795EndometriumAEHpositive regulation of epithelial cell proliferation43/2100207/187234.55e-057.61e-0443
GO:00016562EndometriumAEHmetanephros development22/210085/187231.27e-041.74e-0322
GO:00336872EndometriumAEHosteoblast proliferation11/210032/187234.71e-044.91e-0311
GO:00351073EndometriumAEHappendage morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00351083EndometriumAEHlimb morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00487366EndometriumAEHappendage development33/2100172/187231.41e-031.18e-0233
GO:00601736EndometriumAEHlimb development33/2100172/187231.41e-031.18e-0233
GO:0061448EndometriumAEHconnective tissue development44/2100252/187231.92e-031.51e-0244
GO:00018232EndometriumAEHmesonephros development21/210096/187231.93e-031.52e-0221
GO:0030326EndometriumAEHembryonic limb morphogenesis23/2100116/187234.58e-032.95e-0223
GO:0035113EndometriumAEHembryonic appendage morphogenesis23/2100116/187234.58e-032.95e-0223
GO:0070167EndometriumAEHregulation of biomineral tissue development20/210097/187235.00e-033.14e-0220
GO:0035115EndometriumAEHembryonic forelimb morphogenesis9/210031/187235.59e-033.44e-029
GO:00302822EndometriumAEHbone mineralization23/2100119/187236.32e-033.75e-0223
Page: 1 2 3 4 5 6 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
OSR2GLANEndometriumADJMMP11,SPON2,ISLR, etc.6.05e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2GLANEndometriumAEHMMP11,SPON2,ISLR, etc.3.92e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2PLAEsophagusHealthyOTUD4,OVOL2,STAC, etc.2.68e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2MYOFIBEsophagusADJENTPD2,CTD-2003C8.2,CPZ, etc.6.05e-04The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2SMCEsophagusESCCENTPD2,CTD-2003C8.2,CPZ, etc.2.75e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2MYOFIBEsophagusHealthyENTPD2,CTD-2003C8.2,CPZ, etc.1.31e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2INCAFEsophagusHealthyENTPD2,CTD-2003C8.2,CPZ, etc.1.53e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2MSCEsophagusHealthyENTPD2,CTD-2003C8.2,CPZ, etc.3.30e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2pDCProstateBPHPCOLCE,DCN,GPM6B, etc.1.61e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
OSR2INCAFProstateBPHOLFML3,DCN,LGALS3BP, etc.1.08e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 2 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
OSR2SNVMissense_Mutationc.1124N>Tp.Ser375Phep.S375FQ8N2R0protein_codingdeleterious_low_confidence(0)possibly_damaging(0.76)TCGA-AR-A1AI-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanPD
OSR2SNVMissense_Mutationc.699N>Gp.Asp233Glup.D233EQ8N2R0protein_codingtolerated_low_confidence(0.17)benign(0.013)TCGA-E9-A1NA-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
OSR2SNVMissense_Mutationc.502C>Gp.Gln168Glup.Q168EQ8N2R0protein_codingdeleterious_low_confidence(0)benign(0.244)TCGA-EW-A1PA-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
OSR2insertionNonsense_Mutationnovelc.938_939insATTTTATTAAATCTTATATCCATATAGAAGAATAATTGCAACATAAp.Thr314PhefsTer3p.T314Ffs*3Q8N2R0protein_codingTCGA-A2-A0CT-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
OSR2SNVMissense_Mutationc.1078N>Ap.Gln360Lysp.Q360KQ8N2R0protein_codingdeleterious_low_confidence(0)possibly_damaging(0.694)TCGA-EK-A2PG-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
OSR2SNVMissense_Mutationc.496N>Ap.Ala166Thrp.A166TQ8N2R0protein_codingdeleterious_low_confidence(0.02)probably_damaging(0.993)TCGA-MA-AA3X-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
OSR2SNVMissense_Mutationnovelc.1105N>Cp.Thr369Prop.T369PQ8N2R0protein_codingdeleterious_low_confidence(0.01)possibly_damaging(0.837)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
OSR2SNVMissense_Mutationnovelc.820T>Gp.Leu274Valp.L274VQ8N2R0protein_codingdeleterious_low_confidence(0.03)benign(0.297)TCGA-AA-3684-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
OSR2SNVMissense_Mutationnovelc.709N>Cp.Phe237Leup.F237LQ8N2R0protein_codingdeleterious_low_confidence(0.04)probably_damaging(0.986)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
OSR2SNVMissense_Mutationc.386N>Tp.Ala129Valp.A129VQ8N2R0protein_codingdeleterious_low_confidence(0)probably_damaging(0.99)TCGA-AD-6965-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyoxaliplatinPD
Page: 1 2 3 4 5 6 7 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1