Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: OS9

Gene summary for OS9

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

OS9

Gene ID

10956

Gene nameOS9 endoplasmic reticulum lectin
Gene AliasERLEC2
Cytomap12q13.3-q14.1
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

Q13438


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10956OS9AEH-subject2HumanEndometriumAEH5.53e-08-2.18e-01-0.2525
10956OS9AEH-subject3HumanEndometriumAEH3.90e-16-3.44e-01-0.2576
10956OS9AEH-subject4HumanEndometriumAEH1.05e-06-2.74e-01-0.2657
10956OS9AEH-subject5HumanEndometriumAEH4.08e-12-3.77e-01-0.2953
10956OS9EEC-subject1HumanEndometriumEEC6.27e-18-3.34e-01-0.2682
10956OS9EEC-subject2HumanEndometriumEEC6.12e-13-3.72e-01-0.2607
10956OS9EEC-subject3HumanEndometriumEEC9.85e-35-4.01e-01-0.2525
10956OS9EEC-subject4HumanEndometriumEEC4.43e-05-2.31e-01-0.2571
10956OS9EEC-subject5HumanEndometriumEEC3.29e-04-2.75e-01-0.249
10956OS9GSM5276934HumanEndometriumEEC9.92e-03-1.33e-01-0.0913
10956OS9GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC1.49e-28-2.91e-01-0.1869
10956OS9GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC3.13e-30-2.37e-01-0.1875
10956OS9GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC5.16e-29-3.21e-01-0.1883
10956OS9GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC1.89e-26-7.23e-02-0.1934
10956OS9GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC4.43e-44-2.72e-01-0.1917
10956OS9GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC6.93e-37-3.08e-01-0.1916
10956OS9GSM6177623_NYU_UCEC3_VisHumanEndometriumEEC3.85e-05-2.80e-02-0.1269
10956OS9LZE4THumanEsophagusESCC1.75e-034.21e-010.0811
10956OS9LZE8THumanEsophagusESCC3.67e-032.90e-010.067
10956OS9LZE24THumanEsophagusESCC5.79e-188.86e-010.0596
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001049816EndometriumAEHproteasomal protein catabolic process108/2100490/187232.73e-124.67e-10108
GO:004316116EndometriumAEHproteasome-mediated ubiquitin-dependent protein catabolic process88/2100412/187231.54e-091.36e-0788
GO:003497616EndometriumAEHresponse to endoplasmic reticulum stress62/2100256/187232.88e-092.13e-0762
GO:000660516EndometriumAEHprotein targeting68/2100314/187236.30e-083.38e-0668
GO:003315710EndometriumAEHregulation of intracellular protein transport51/2100229/187231.13e-063.75e-0551
GO:003596616EndometriumAEHresponse to topologically incorrect protein39/2100159/187231.69e-065.23e-0539
GO:000698616EndometriumAEHresponse to unfolded protein35/2100137/187232.09e-066.28e-0535
GO:004518516EndometriumAEHmaintenance of protein location27/210094/187232.78e-067.89e-0527
GO:00709727EndometriumAEHprotein localization to endoplasmic reticulum23/210074/187233.44e-069.24e-0523
GO:00323869EndometriumAEHregulation of intracellular transport66/2100337/187234.18e-061.10e-0466
GO:00325078EndometriumAEHmaintenance of protein location in cell21/210065/187234.56e-061.18e-0421
GO:003462015EndometriumAEHcellular response to unfolded protein25/210096/187234.07e-056.97e-0425
GO:005165116EndometriumAEHmaintenance of location in cell44/2100214/187234.84e-057.94e-0444
GO:003596716EndometriumAEHcellular response to topologically incorrect protein28/2100116/187236.38e-059.94e-0428
GO:005123510EndometriumAEHmaintenance of location60/2100327/187238.19e-051.22e-0360
GO:00725956EndometriumAEHmaintenance of protein localization in organelle14/210042/187231.20e-041.67e-0314
GO:00510515EndometriumAEHnegative regulation of transport79/2100470/187231.51e-041.99e-0379
GO:00365033EndometriumAEHERAD pathway23/2100107/187231.55e-031.27e-0223
GO:00354375EndometriumAEHmaintenance of protein localization in endoplasmic reticulum6/210014/187232.67e-031.94e-026
GO:00309689EndometriumAEHendoplasmic reticulum unfolded protein response17/210074/187232.92e-032.08e-0217
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0414126EndometriumAEHProtein processing in endoplasmic reticulum62/1197174/84655.97e-131.39e-111.01e-1162
hsa04141111EndometriumAEHProtein processing in endoplasmic reticulum62/1197174/84655.97e-131.39e-111.01e-1162
hsa0414127EndometriumEECProtein processing in endoplasmic reticulum64/1237174/84652.17e-135.09e-123.80e-1264
hsa0414136EndometriumEECProtein processing in endoplasmic reticulum64/1237174/84652.17e-135.09e-123.80e-1264
hsa04141211EsophagusESCCProtein processing in endoplasmic reticulum147/4205174/84653.29e-221.10e-195.64e-20147
hsa04141310EsophagusESCCProtein processing in endoplasmic reticulum147/4205174/84653.29e-221.10e-195.64e-20147
hsa0414114LiverCirrhoticProtein processing in endoplasmic reticulum114/2530174/84651.16e-229.67e-215.96e-21114
hsa0414115LiverCirrhoticProtein processing in endoplasmic reticulum114/2530174/84651.16e-229.67e-215.96e-21114
hsa0414122LiverHCCProtein processing in endoplasmic reticulum146/4020174/84657.34e-242.46e-211.37e-21146
hsa0414132LiverHCCProtein processing in endoplasmic reticulum146/4020174/84657.34e-242.46e-211.37e-21146
hsa0414130Oral cavityOSCCProtein processing in endoplasmic reticulum143/3704174/84656.82e-262.28e-231.16e-23143
hsa04141113Oral cavityOSCCProtein processing in endoplasmic reticulum143/3704174/84656.82e-262.28e-231.16e-23143
hsa04141210Oral cavityLPProtein processing in endoplasmic reticulum113/2418174/84658.74e-245.82e-223.76e-22113
hsa0414138Oral cavityLPProtein processing in endoplasmic reticulum113/2418174/84658.74e-245.82e-223.76e-22113
hsa0414145Oral cavityEOLPProtein processing in endoplasmic reticulum70/1218174/84652.84e-173.06e-151.81e-1570
hsa0414155Oral cavityEOLPProtein processing in endoplasmic reticulum70/1218174/84652.84e-173.06e-151.81e-1570
hsa0414128ProstateBPHProtein processing in endoplasmic reticulum97/1718174/84652.37e-251.30e-238.07e-2497
hsa04141112ProstateBPHProtein processing in endoplasmic reticulum97/1718174/84652.37e-251.30e-238.07e-2497
hsa0414129ProstateTumorProtein processing in endoplasmic reticulum99/1791174/84652.58e-251.71e-231.06e-2399
hsa0414137ProstateTumorProtein processing in endoplasmic reticulum99/1791174/84652.58e-251.71e-231.06e-2399
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
OS9SNVMissense_Mutationc.451G>Ap.Ala151Thrp.A151TQ13438protein_codingtolerated(0.07)benign(0.037)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
OS9SNVMissense_Mutationnovelc.74C>Gp.Thr25Serp.T25SQ13438protein_codingtolerated(0.82)benign(0.197)TCGA-AQ-A54O-01Breastbreast invasive carcinomaMale<65I/IIChemotherapyadriamycinCR
OS9SNVMissense_Mutationc.1261N>Ap.Glu421Lysp.E421KQ13438protein_codingtolerated(0.22)benign(0.034)TCGA-E2-A159-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
OS9insertionFrame_Shift_Insnovelc.1757_1758insCACTCTCAACAAACTCATCAAAp.Ala587ThrfsTer13p.A587Tfs*13Q13438protein_codingTCGA-A2-A04Y-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
OS9insertionIn_Frame_Insnovelc.1979_1980insTAAATTATTTCTTCTTCTTGTATCCCCTTGTGTCCATTTCATAGTp.Gly660_Asp661insLysLeuPheLeuLeuLeuValSerProCysValHisPheIleValp.G660_D661insKLFLLLVSPCVHFIVQ13438protein_codingTCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
OS9insertionNonsense_Mutationnovelc.1744_1745insCAGTAGAAGGCCTGGAACTGAATAAACTAAATGGTTAATATTTGTp.Arg582delinsThrValGluGlyLeuGluLeuAsnLysLeuAsnGlyTerTyrLeuTrpp.R582delinsTVEGLELNKLNG*YLWQ13438protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
OS9insertionFrame_Shift_Insnovelc.1994_1995insGGGAp.Phe665LeufsTer3p.F665Lfs*3Q13438protein_codingTCGA-AN-A0FL-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
OS9insertionNonsense_Mutationnovelc.1996_1997insGAGGGGAGAGCTAAGCCTGGGAGGGAGGTTGGGTp.Asp666GlyfsTer5p.D666Gfs*5Q13438protein_codingTCGA-AN-A0FL-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
OS9SNVMissense_Mutationrs770299465c.497N>Ap.Arg166Hisp.R166HQ13438protein_codingdeleterious(0)probably_damaging(0.996)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
OS9SNVMissense_Mutationnovelc.1789N>Tp.Arg597Cysp.R597CQ13438protein_codingdeleterious(0.01)possibly_damaging(0.828)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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