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Gene: ORAOV1 |
Gene summary for ORAOV1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ORAOV1 | Gene ID | 220064 |
Gene name | LTO1 maturation factor of ABCE1 | |
Gene Alias | CIAB1 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | A0A024R5H3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
220064 | ORAOV1 | P1T-E | Human | Esophagus | ESCC | 2.78e-24 | 1.18e+00 | 0.0875 |
220064 | ORAOV1 | P2T-E | Human | Esophagus | ESCC | 2.62e-89 | 1.54e+00 | 0.1177 |
220064 | ORAOV1 | P4T-E | Human | Esophagus | ESCC | 8.08e-17 | 4.08e-01 | 0.1323 |
220064 | ORAOV1 | P5T-E | Human | Esophagus | ESCC | 9.99e-16 | 3.47e-01 | 0.1327 |
220064 | ORAOV1 | P8T-E | Human | Esophagus | ESCC | 1.84e-19 | 3.88e-01 | 0.0889 |
220064 | ORAOV1 | P9T-E | Human | Esophagus | ESCC | 5.57e-05 | 1.57e-01 | 0.1131 |
220064 | ORAOV1 | P10T-E | Human | Esophagus | ESCC | 1.24e-12 | 2.24e-01 | 0.116 |
220064 | ORAOV1 | P11T-E | Human | Esophagus | ESCC | 1.81e-02 | 2.48e-01 | 0.1426 |
220064 | ORAOV1 | P12T-E | Human | Esophagus | ESCC | 8.83e-13 | 2.23e-01 | 0.1122 |
220064 | ORAOV1 | P15T-E | Human | Esophagus | ESCC | 2.50e-09 | 3.18e-01 | 0.1149 |
220064 | ORAOV1 | P16T-E | Human | Esophagus | ESCC | 7.25e-69 | 1.10e+00 | 0.1153 |
220064 | ORAOV1 | P17T-E | Human | Esophagus | ESCC | 3.46e-11 | 6.39e-01 | 0.1278 |
220064 | ORAOV1 | P19T-E | Human | Esophagus | ESCC | 5.41e-06 | 4.73e-01 | 0.1662 |
220064 | ORAOV1 | P20T-E | Human | Esophagus | ESCC | 1.75e-22 | 5.85e-01 | 0.1124 |
220064 | ORAOV1 | P21T-E | Human | Esophagus | ESCC | 7.97e-12 | 3.33e-01 | 0.1617 |
220064 | ORAOV1 | P22T-E | Human | Esophagus | ESCC | 2.61e-68 | 1.03e+00 | 0.1236 |
220064 | ORAOV1 | P23T-E | Human | Esophagus | ESCC | 1.15e-73 | 1.71e+00 | 0.108 |
220064 | ORAOV1 | P24T-E | Human | Esophagus | ESCC | 1.02e-18 | 4.50e-01 | 0.1287 |
220064 | ORAOV1 | P26T-E | Human | Esophagus | ESCC | 1.85e-76 | 1.24e+00 | 0.1276 |
220064 | ORAOV1 | P27T-E | Human | Esophagus | ESCC | 6.54e-65 | 1.35e+00 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ORAOV1 | SNV | Missense_Mutation | novel | c.67N>C | p.Tyr23His | p.Y23H | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ORAOV1 | SNV | Missense_Mutation | novel | c.321N>A | p.Asp107Glu | p.D107E | Q8WV07 | protein_coding | tolerated(1) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ORAOV1 | SNV | Missense_Mutation | c.172N>T | p.Gly58Cys | p.G58C | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ORAOV1 | SNV | Missense_Mutation | novel | c.359N>G | p.Leu120Arg | p.L120R | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ORAOV1 | SNV | Missense_Mutation | rs759989062 | c.353C>T | p.Ser118Leu | p.S118L | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ORAOV1 | SNV | Missense_Mutation | rs759989062 | c.353C>T | p.Ser118Leu | p.S118L | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ORAOV1 | SNV | Missense_Mutation | novel | c.373N>T | p.Asp125Tyr | p.D125Y | Q8WV07 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ORAOV1 | SNV | Missense_Mutation | rs759989062 | c.353N>T | p.Ser118Leu | p.S118L | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ORAOV1 | SNV | Missense_Mutation | rs759989062 | c.353C>T | p.Ser118Leu | p.S118L | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ORAOV1 | SNV | Missense_Mutation | rs759989062 | c.353N>T | p.Ser118Leu | p.S118L | Q8WV07 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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