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Gene: ORAI3 |
Gene summary for ORAI3 |
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Gene information | Species | Human | Gene symbol | ORAI3 | Gene ID | 93129 |
Gene name | ORAI calcium release-activated calcium modulator 3 | |
Gene Alias | TMEM142C | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0002115 | UniProtAcc | A0A024QZA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93129 | ORAI3 | LZE4T | Human | Esophagus | ESCC | 1.81e-05 | 1.36e-01 | 0.0811 |
93129 | ORAI3 | LZE7T | Human | Esophagus | ESCC | 2.49e-03 | 1.74e-01 | 0.0667 |
93129 | ORAI3 | LZE20T | Human | Esophagus | ESCC | 3.00e-05 | 2.14e-01 | 0.0662 |
93129 | ORAI3 | LZE22T | Human | Esophagus | ESCC | 2.64e-04 | 2.79e-01 | 0.068 |
93129 | ORAI3 | LZE24T | Human | Esophagus | ESCC | 2.57e-13 | 3.70e-01 | 0.0596 |
93129 | ORAI3 | LZE21T | Human | Esophagus | ESCC | 7.67e-04 | 2.65e-01 | 0.0655 |
93129 | ORAI3 | P1T-E | Human | Esophagus | ESCC | 2.55e-05 | 5.71e-01 | 0.0875 |
93129 | ORAI3 | P2T-E | Human | Esophagus | ESCC | 1.69e-45 | 9.34e-01 | 0.1177 |
93129 | ORAI3 | P4T-E | Human | Esophagus | ESCC | 1.61e-41 | 1.09e+00 | 0.1323 |
93129 | ORAI3 | P5T-E | Human | Esophagus | ESCC | 2.34e-04 | 1.05e-01 | 0.1327 |
93129 | ORAI3 | P8T-E | Human | Esophagus | ESCC | 3.09e-30 | 5.95e-01 | 0.0889 |
93129 | ORAI3 | P9T-E | Human | Esophagus | ESCC | 4.14e-16 | 3.62e-01 | 0.1131 |
93129 | ORAI3 | P10T-E | Human | Esophagus | ESCC | 2.49e-20 | 2.70e-01 | 0.116 |
93129 | ORAI3 | P11T-E | Human | Esophagus | ESCC | 4.45e-18 | 8.08e-01 | 0.1426 |
93129 | ORAI3 | P12T-E | Human | Esophagus | ESCC | 8.32e-27 | 5.33e-01 | 0.1122 |
93129 | ORAI3 | P15T-E | Human | Esophagus | ESCC | 2.43e-18 | 4.91e-01 | 0.1149 |
93129 | ORAI3 | P16T-E | Human | Esophagus | ESCC | 2.86e-22 | 3.97e-01 | 0.1153 |
93129 | ORAI3 | P17T-E | Human | Esophagus | ESCC | 1.42e-03 | 2.87e-01 | 0.1278 |
93129 | ORAI3 | P20T-E | Human | Esophagus | ESCC | 4.11e-16 | 4.46e-01 | 0.1124 |
93129 | ORAI3 | P21T-E | Human | Esophagus | ESCC | 1.17e-12 | 1.90e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ORAI3 | deletion | Frame_Shift_Del | novel | c.603delT | p.Thr202ProfsTer81 | p.T202Pfs*81 | Q9BRQ5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ORAI3 | SNV | Missense_Mutation | novel | c.338T>C | p.Leu113Pro | p.L113P | Q9BRQ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ORAI3 | SNV | Missense_Mutation | rs868345841 | c.74N>T | p.Ala25Val | p.A25V | Q9BRQ5 | protein_coding | tolerated_low_confidence(0.42) | benign(0.003) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
ORAI3 | SNV | Missense_Mutation | rs553613759 | c.583N>A | p.Gly195Arg | p.G195R | Q9BRQ5 | protein_coding | tolerated_low_confidence(0.13) | benign(0.006) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ORAI3 | SNV | Missense_Mutation | novel | c.319G>A | p.Ala107Thr | p.A107T | Q9BRQ5 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ORAI3 | SNV | Missense_Mutation | c.691G>T | p.Ala231Ser | p.A231S | Q9BRQ5 | protein_coding | tolerated_low_confidence(0.8) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ORAI3 | SNV | Missense_Mutation | novel | c.658N>C | p.Ser220Pro | p.S220P | Q9BRQ5 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ORAI3 | SNV | Missense_Mutation | novel | c.860N>A | p.Arg287His | p.R287H | Q9BRQ5 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ORAI3 | SNV | Missense_Mutation | c.551N>T | p.Pro184Leu | p.P184L | Q9BRQ5 | protein_coding | tolerated(0.4) | benign(0.044) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ORAI3 | SNV | Missense_Mutation | c.754N>G | p.Met252Val | p.M252V | Q9BRQ5 | protein_coding | tolerated(0.14) | probably_damaging(0.977) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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