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Gene: OPLAH |
Gene summary for OPLAH |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | OPLAH | Gene ID | 26873 |
| Gene name | 5-oxoprolinase, ATP-hydrolysing | |
| Gene Alias | 5-Opase | |
| Cytomap | 8q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0006518 | UniProtAcc | O14841 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26873 | OPLAH | LZE24T | Human | Esophagus | ESCC | 1.27e-06 | 1.48e-01 | 0.0596 |
| 26873 | OPLAH | P1T-E | Human | Esophagus | ESCC | 2.56e-05 | 2.80e-01 | 0.0875 |
| 26873 | OPLAH | P2T-E | Human | Esophagus | ESCC | 4.59e-07 | 1.01e-01 | 0.1177 |
| 26873 | OPLAH | P4T-E | Human | Esophagus | ESCC | 5.63e-03 | 1.13e-01 | 0.1323 |
| 26873 | OPLAH | P5T-E | Human | Esophagus | ESCC | 2.88e-09 | 9.76e-02 | 0.1327 |
| 26873 | OPLAH | P8T-E | Human | Esophagus | ESCC | 1.01e-10 | 1.01e-01 | 0.0889 |
| 26873 | OPLAH | P9T-E | Human | Esophagus | ESCC | 1.48e-08 | 1.66e-01 | 0.1131 |
| 26873 | OPLAH | P10T-E | Human | Esophagus | ESCC | 1.66e-02 | 3.38e-02 | 0.116 |
| 26873 | OPLAH | P12T-E | Human | Esophagus | ESCC | 6.86e-21 | 3.99e-01 | 0.1122 |
| 26873 | OPLAH | P15T-E | Human | Esophagus | ESCC | 1.03e-05 | 1.42e-01 | 0.1149 |
| 26873 | OPLAH | P16T-E | Human | Esophagus | ESCC | 4.19e-25 | 3.34e-01 | 0.1153 |
| 26873 | OPLAH | P20T-E | Human | Esophagus | ESCC | 2.97e-06 | 1.56e-01 | 0.1124 |
| 26873 | OPLAH | P21T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.14e-01 | 0.1617 |
| 26873 | OPLAH | P22T-E | Human | Esophagus | ESCC | 6.33e-10 | 7.34e-02 | 0.1236 |
| 26873 | OPLAH | P23T-E | Human | Esophagus | ESCC | 1.48e-02 | 1.25e-01 | 0.108 |
| 26873 | OPLAH | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.63e-02 | 0.1287 |
| 26873 | OPLAH | P26T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.09e-01 | 0.1276 |
| 26873 | OPLAH | P27T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.46e-02 | 0.1055 |
| 26873 | OPLAH | P28T-E | Human | Esophagus | ESCC | 1.12e-12 | 2.30e-01 | 0.1149 |
| 26873 | OPLAH | P30T-E | Human | Esophagus | ESCC | 1.51e-07 | 2.26e-01 | 0.137 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
| GO:000674912 | Esophagus | ESCC | glutathione metabolic process | 42/8552 | 64/18723 | 1.01e-03 | 5.12e-03 | 42 |
| GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
| GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
| GO:000674911 | Liver | HCC | glutathione metabolic process | 44/7958 | 64/18723 | 1.95e-05 | 2.09e-04 | 44 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
| hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| OPLAH | SNV | Missense_Mutation | novel | c.3053N>G | p.Pro1018Arg | p.P1018R | O14841 | protein_coding | tolerated(0.08) | benign(0.297) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD |
| OPLAH | SNV | Missense_Mutation | rs372767256 | c.2265C>G | p.Ile755Met | p.I755M | O14841 | protein_coding | tolerated(0.07) | possibly_damaging(0.878) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.3046N>T | p.Thr1016Ser | p.T1016S | O14841 | protein_coding | tolerated(0.17) | benign(0.018) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| OPLAH | deletion | Frame_Shift_Del | novel | c.2001delT | p.Phe667LeufsTer45 | p.F667Lfs*45 | O14841 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| OPLAH | SNV | Missense_Mutation | novel | c.3479N>A | p.Arg1160His | p.R1160H | O14841 | protein_coding | tolerated(0.27) | possibly_damaging(0.836) | TCGA-C5-A1MF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.974A>C | p.Tyr325Ser | p.Y325S | O14841 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.217N>T | p.His73Tyr | p.H73Y | O14841 | protein_coding | tolerated(0.3) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.1493N>T | p.Ala498Val | p.A498V | O14841 | protein_coding | deleterious(0) | possibly_damaging(0.602) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.3419N>C | p.Met1140Thr | p.M1140T | O14841 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| OPLAH | SNV | Missense_Mutation | novel | c.934N>A | p.Gly312Ser | p.G312S | O14841 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 26873 | OPLAH | ENZYME | MELPHALAN | MELPHALAN | 9751079 |
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