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Gene: OGA |
Gene summary for OGA |
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Gene information | Species | Human | Gene symbol | OGA | Gene ID | 10724 |
Gene name | O-GlcNAcase | |
Gene Alias | MEA5 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0006040 | UniProtAcc | O60502 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10724 | OGA | GSM4909281 | Human | Breast | IDC | 1.18e-03 | 2.42e-01 | 0.21 |
10724 | OGA | GSM4909286 | Human | Breast | IDC | 2.48e-03 | 1.34e-01 | 0.1081 |
10724 | OGA | GSM4909293 | Human | Breast | IDC | 2.12e-12 | 2.82e-01 | 0.1581 |
10724 | OGA | GSM4909295 | Human | Breast | IDC | 2.36e-03 | 3.10e-01 | 0.0898 |
10724 | OGA | GSM4909298 | Human | Breast | IDC | 8.00e-11 | 3.39e-01 | 0.1551 |
10724 | OGA | GSM4909299 | Human | Breast | IDC | 2.37e-03 | 1.87e-01 | 0.035 |
10724 | OGA | GSM4909301 | Human | Breast | IDC | 4.79e-05 | 3.81e-01 | 0.1577 |
10724 | OGA | GSM4909302 | Human | Breast | IDC | 4.74e-02 | 2.44e-01 | 0.1545 |
10724 | OGA | GSM4909304 | Human | Breast | IDC | 2.67e-04 | 2.22e-01 | 0.1636 |
10724 | OGA | GSM4909305 | Human | Breast | IDC | 2.87e-05 | 2.75e-01 | 0.0436 |
10724 | OGA | GSM4909308 | Human | Breast | IDC | 6.78e-08 | 2.35e-01 | 0.158 |
10724 | OGA | GSM4909311 | Human | Breast | IDC | 9.30e-05 | -8.74e-02 | 0.1534 |
10724 | OGA | GSM4909317 | Human | Breast | IDC | 4.48e-05 | 2.17e-01 | 0.1355 |
10724 | OGA | GSM4909319 | Human | Breast | IDC | 2.72e-08 | -1.49e-01 | 0.1563 |
10724 | OGA | ctrl6 | Human | Breast | Precancer | 7.17e-17 | 5.94e-01 | -0.0061 |
10724 | OGA | brca1 | Human | Breast | Precancer | 8.07e-06 | -2.10e-01 | -0.0338 |
10724 | OGA | brca2 | Human | Breast | Precancer | 8.25e-07 | -2.10e-01 | -0.024 |
10724 | OGA | brca3 | Human | Breast | Precancer | 8.25e-07 | -2.10e-01 | -0.0263 |
10724 | OGA | M1 | Human | Breast | IDC | 1.93e-18 | 5.52e-01 | 0.1577 |
10724 | OGA | P1 | Human | Breast | IDC | 5.18e-06 | 3.21e-01 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0090307 | Colorectum | AD | mitotic spindle assembly | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04931 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa049311 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa049312 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa049313 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa049314 | Colorectum | CRC | Insulin resistance | 28/1091 | 108/8465 | 1.78e-04 | 2.37e-03 | 1.61e-03 | 28 |
hsa049315 | Colorectum | CRC | Insulin resistance | 28/1091 | 108/8465 | 1.78e-04 | 2.37e-03 | 1.61e-03 | 28 |
hsa049318 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0493113 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa049316 | Liver | NAFLD | Insulin resistance | 29/1043 | 108/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 29 |
hsa0493111 | Liver | NAFLD | Insulin resistance | 29/1043 | 108/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 29 |
hsa0493121 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0493131 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10724 | OGA | ENZYME, DRUGGABLE GENOME | MK 8719 | |||
10724 | OGA | ENZYME, DRUGGABLE GENOME | inhibitor | 387065591 | CHEMBL1213603 | |
10724 | OGA | ENZYME, DRUGGABLE GENOME | inhibitor | 387065590 | ||
10724 | OGA | ENZYME, DRUGGABLE GENOME | STZ | STREPTOZOCIN | 11336633 |
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