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Gene: ODF3B |
Gene summary for ODF3B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ODF3B | Gene ID | 440836 |
| Gene name | outer dense fiber of sperm tails 3B | |
| Gene Alias | FAP123 | |
| Cytomap | 22q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A1L1A8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 440836 | ODF3B | LZE4T | Human | Esophagus | ESCC | 2.09e-07 | 3.04e-01 | 0.0811 |
| 440836 | ODF3B | LZE7T | Human | Esophagus | ESCC | 2.54e-03 | 5.63e-02 | 0.0667 |
| 440836 | ODF3B | LZE8T | Human | Esophagus | ESCC | 5.11e-05 | 1.20e-01 | 0.067 |
| 440836 | ODF3B | LZE20T | Human | Esophagus | ESCC | 7.81e-08 | 6.17e-01 | 0.0662 |
| 440836 | ODF3B | LZE22D1 | Human | Esophagus | HGIN | 9.45e-05 | 4.61e-01 | 0.0595 |
| 440836 | ODF3B | LZE24T | Human | Esophagus | ESCC | 2.24e-30 | 1.16e+00 | 0.0596 |
| 440836 | ODF3B | LZE21T | Human | Esophagus | ESCC | 2.46e-08 | 8.84e-01 | 0.0655 |
| 440836 | ODF3B | LZE6T | Human | Esophagus | ESCC | 7.38e-05 | 1.49e-01 | 0.0845 |
| 440836 | ODF3B | P1T-E | Human | Esophagus | ESCC | 7.29e-36 | 2.48e+00 | 0.0875 |
| 440836 | ODF3B | P2T-E | Human | Esophagus | ESCC | 4.46e-112 | 2.09e+00 | 0.1177 |
| 440836 | ODF3B | P4T-E | Human | Esophagus | ESCC | 1.08e-20 | 7.35e-01 | 0.1323 |
| 440836 | ODF3B | P5T-E | Human | Esophagus | ESCC | 1.11e-97 | 1.89e+00 | 0.1327 |
| 440836 | ODF3B | P8T-E | Human | Esophagus | ESCC | 3.23e-54 | 1.21e+00 | 0.0889 |
| 440836 | ODF3B | P9T-E | Human | Esophagus | ESCC | 8.90e-81 | 2.28e+00 | 0.1131 |
| 440836 | ODF3B | P10T-E | Human | Esophagus | ESCC | 3.29e-03 | 1.73e-01 | 0.116 |
| 440836 | ODF3B | P11T-E | Human | Esophagus | ESCC | 6.42e-50 | 3.48e+00 | 0.1426 |
| 440836 | ODF3B | P12T-E | Human | Esophagus | ESCC | 1.26e-07 | 3.74e-01 | 0.1122 |
| 440836 | ODF3B | P15T-E | Human | Esophagus | ESCC | 1.13e-34 | 1.39e+00 | 0.1149 |
| 440836 | ODF3B | P16T-E | Human | Esophagus | ESCC | 5.54e-25 | 5.85e-01 | 0.1153 |
| 440836 | ODF3B | P17T-E | Human | Esophagus | ESCC | 1.17e-49 | 2.71e+00 | 0.1278 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ODF3B | SNV | Missense_Mutation | rs754401271 | c.554G>A | p.Cys185Tyr | p.C185Y | A8MYP8 | protein_coding | deleterious(0.01) | possibly_damaging(0.694) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ODF3B | SNV | Missense_Mutation | c.752N>A | p.Ala251Glu | p.A251E | A8MYP8 | protein_coding | tolerated(0.09) | benign(0.03) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD | |
| ODF3B | SNV | Missense_Mutation | c.598N>T | p.Pro200Ser | p.P200S | A8MYP8 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-56-6545-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ODF3B | SNV | Missense_Mutation | novel | c.364N>T | p.Arg122Trp | p.R122W | A8MYP8 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-P3-A5Q5-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ODF3B | SNV | Missense_Mutation | novel | c.349T>C | p.Tyr117His | p.Y117H | A8MYP8 | protein_coding | tolerated(0.08) | possibly_damaging(0.898) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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