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Gene: OBFC1 |
Gene summary for OBFC1 |
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Gene information | Species | Human | Gene symbol | OBFC1 | Gene ID | 79991 |
Gene name | STN1 subunit of CST complex | |
Gene Alias | AAF-44 | |
Cytomap | 10q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q9H668 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79991 | OBFC1 | P1T-E | Human | Esophagus | ESCC | 1.71e-04 | 2.61e-01 | 0.0875 |
79991 | OBFC1 | P2T-E | Human | Esophagus | ESCC | 6.61e-24 | 3.70e-01 | 0.1177 |
79991 | OBFC1 | P4T-E | Human | Esophagus | ESCC | 1.77e-13 | 2.63e-01 | 0.1323 |
79991 | OBFC1 | P5T-E | Human | Esophagus | ESCC | 2.96e-18 | 3.41e-01 | 0.1327 |
79991 | OBFC1 | P8T-E | Human | Esophagus | ESCC | 2.08e-04 | 1.70e-01 | 0.0889 |
79991 | OBFC1 | P9T-E | Human | Esophagus | ESCC | 8.09e-07 | 1.48e-01 | 0.1131 |
79991 | OBFC1 | P10T-E | Human | Esophagus | ESCC | 1.19e-04 | 7.54e-02 | 0.116 |
79991 | OBFC1 | P11T-E | Human | Esophagus | ESCC | 6.69e-10 | 2.17e-01 | 0.1426 |
79991 | OBFC1 | P12T-E | Human | Esophagus | ESCC | 1.30e-09 | 2.45e-01 | 0.1122 |
79991 | OBFC1 | P15T-E | Human | Esophagus | ESCC | 2.98e-12 | 2.28e-01 | 0.1149 |
79991 | OBFC1 | P16T-E | Human | Esophagus | ESCC | 3.23e-19 | 2.83e-01 | 0.1153 |
79991 | OBFC1 | P17T-E | Human | Esophagus | ESCC | 2.16e-14 | 4.48e-01 | 0.1278 |
79991 | OBFC1 | P19T-E | Human | Esophagus | ESCC | 7.55e-03 | 3.41e-01 | 0.1662 |
79991 | OBFC1 | P20T-E | Human | Esophagus | ESCC | 1.40e-22 | 4.29e-01 | 0.1124 |
79991 | OBFC1 | P21T-E | Human | Esophagus | ESCC | 2.17e-20 | 4.35e-01 | 0.1617 |
79991 | OBFC1 | P22T-E | Human | Esophagus | ESCC | 9.10e-15 | 1.63e-01 | 0.1236 |
79991 | OBFC1 | P23T-E | Human | Esophagus | ESCC | 2.88e-23 | 5.75e-01 | 0.108 |
79991 | OBFC1 | P24T-E | Human | Esophagus | ESCC | 4.47e-10 | 2.65e-01 | 0.1287 |
79991 | OBFC1 | P26T-E | Human | Esophagus | ESCC | 6.10e-15 | 3.12e-01 | 0.1276 |
79991 | OBFC1 | P27T-E | Human | Esophagus | ESCC | 2.61e-14 | 2.91e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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