|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: OARD1 |
Gene summary for OARD1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | OARD1 | Gene ID | 221443 |
| Gene name | O-acyl-ADP-ribose deacylase 1 | |
| Gene Alias | C6orf130 | |
| Cytomap | 6p21.1 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCY9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 221443 | OARD1 | LZE2T | Human | Esophagus | ESCC | 8.69e-04 | 1.18e+00 | 0.082 |
| 221443 | OARD1 | LZE3D | Human | Esophagus | HGIN | 1.69e-04 | 5.48e-01 | 0.0668 |
| 221443 | OARD1 | LZE4T | Human | Esophagus | ESCC | 6.11e-04 | 1.02e-01 | 0.0811 |
| 221443 | OARD1 | LZE7T | Human | Esophagus | ESCC | 1.73e-09 | 3.00e-01 | 0.0667 |
| 221443 | OARD1 | LZE8T | Human | Esophagus | ESCC | 4.25e-05 | 7.03e-02 | 0.067 |
| 221443 | OARD1 | LZE20T | Human | Esophagus | ESCC | 2.47e-04 | 1.41e-01 | 0.0662 |
| 221443 | OARD1 | LZE24T | Human | Esophagus | ESCC | 3.13e-15 | 4.63e-01 | 0.0596 |
| 221443 | OARD1 | LZE21T | Human | Esophagus | ESCC | 2.02e-06 | 2.78e-01 | 0.0655 |
| 221443 | OARD1 | LZE6T | Human | Esophagus | ESCC | 6.19e-06 | 1.95e-01 | 0.0845 |
| 221443 | OARD1 | P1T-E | Human | Esophagus | ESCC | 7.24e-08 | 3.17e-01 | 0.0875 |
| 221443 | OARD1 | P2T-E | Human | Esophagus | ESCC | 3.71e-25 | 4.49e-01 | 0.1177 |
| 221443 | OARD1 | P4T-E | Human | Esophagus | ESCC | 4.07e-24 | 6.77e-01 | 0.1323 |
| 221443 | OARD1 | P5T-E | Human | Esophagus | ESCC | 8.85e-19 | 1.87e-01 | 0.1327 |
| 221443 | OARD1 | P8T-E | Human | Esophagus | ESCC | 8.26e-18 | 3.76e-01 | 0.0889 |
| 221443 | OARD1 | P9T-E | Human | Esophagus | ESCC | 2.27e-20 | 1.96e-01 | 0.1131 |
| 221443 | OARD1 | P10T-E | Human | Esophagus | ESCC | 1.39e-20 | 3.50e-01 | 0.116 |
| 221443 | OARD1 | P11T-E | Human | Esophagus | ESCC | 1.15e-12 | 3.72e-01 | 0.1426 |
| 221443 | OARD1 | P12T-E | Human | Esophagus | ESCC | 9.51e-29 | 5.19e-01 | 0.1122 |
| 221443 | OARD1 | P15T-E | Human | Esophagus | ESCC | 5.48e-13 | 2.80e-01 | 0.1149 |
| 221443 | OARD1 | P16T-E | Human | Esophagus | ESCC | 5.34e-29 | 7.48e-01 | 0.1153 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
| GO:19016574 | Esophagus | ESCC | glycosyl compound metabolic process | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
| GO:00091163 | Esophagus | ESCC | nucleoside metabolic process | 39/8552 | 62/18723 | 4.68e-03 | 1.82e-02 | 39 |
| GO:007252112 | Liver | Cirrhotic | purine-containing compound metabolic process | 156/4634 | 416/18723 | 3.74e-09 | 1.52e-07 | 156 |
| GO:19016572 | Liver | Cirrhotic | glycosyl compound metabolic process | 37/4634 | 88/18723 | 2.70e-04 | 2.40e-03 | 37 |
| GO:0042278 | Liver | Cirrhotic | purine nucleoside metabolic process | 13/4634 | 26/18723 | 4.72e-03 | 2.48e-02 | 13 |
| GO:0009116 | Liver | Cirrhotic | nucleoside metabolic process | 25/4634 | 62/18723 | 4.90e-03 | 2.56e-02 | 25 |
| GO:007252122 | Liver | HCC | purine-containing compound metabolic process | 250/7958 | 416/18723 | 2.26e-13 | 1.24e-11 | 250 |
| GO:19016571 | Liver | HCC | glycosyl compound metabolic process | 55/7958 | 88/18723 | 1.20e-04 | 1.01e-03 | 55 |
| GO:00091161 | Liver | HCC | nucleoside metabolic process | 37/7958 | 62/18723 | 4.73e-03 | 2.02e-02 | 37 |
| GO:19016573 | Oral cavity | OSCC | glycosyl compound metabolic process | 52/7305 | 88/18723 | 1.06e-04 | 7.84e-04 | 52 |
| GO:007252120 | Oral cavity | OSCC | purine-containing compound metabolic process | 199/7305 | 416/18723 | 1.34e-04 | 9.53e-04 | 199 |
| GO:00091162 | Oral cavity | OSCC | nucleoside metabolic process | 37/7305 | 62/18723 | 7.79e-04 | 4.23e-03 | 37 |
| GO:190165711 | Oral cavity | LP | glycosyl compound metabolic process | 43/4623 | 88/18723 | 7.80e-07 | 2.05e-05 | 43 |
| GO:000911611 | Oral cavity | LP | nucleoside metabolic process | 31/4623 | 62/18723 | 1.46e-05 | 2.57e-04 | 31 |
| GO:0072521110 | Oral cavity | LP | purine-containing compound metabolic process | 130/4623 | 416/18723 | 1.30e-03 | 1.05e-02 | 130 |
| GO:00422781 | Oral cavity | LP | purine nucleoside metabolic process | 14/4623 | 26/18723 | 1.33e-03 | 1.07e-02 | 14 |
| GO:0072521112 | Skin | cSCC | purine-containing compound metabolic process | 150/4864 | 416/18723 | 2.88e-06 | 4.54e-05 | 150 |
| GO:19016575 | Skin | cSCC | glycosyl compound metabolic process | 37/4864 | 88/18723 | 7.39e-04 | 5.15e-03 | 37 |
| GO:00091164 | Skin | cSCC | nucleoside metabolic process | 27/4864 | 62/18723 | 1.99e-03 | 1.19e-02 | 27 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| OARD1 | SNV | Missense_Mutation | rs770268622 | c.263C>T | p.Ser88Leu | p.S88L | Q9Y530 | protein_coding | tolerated(0.64) | benign(0.214) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | rs770268622 | c.263N>T | p.Ser88Leu | p.S88L | Q9Y530 | protein_coding | tolerated(0.64) | benign(0.214) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | rs769331533 | c.376N>T | p.Arg126Cys | p.R126C | Q9Y530 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | rs769331533 | c.376C>T | p.Arg126Cys | p.R126C | Q9Y530 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | novel | c.343N>A | p.Leu115Ile | p.L115I | Q9Y530 | protein_coding | tolerated(0.69) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | rs529411165 | c.409N>A | p.Glu137Lys | p.E137K | Q9Y530 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| OARD1 | SNV | Missense_Mutation | c.445N>A | p.Val149Met | p.V149M | Q9Y530 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | |
| OARD1 | SNV | Missense_Mutation | novel | c.150N>T | p.Lys50Asn | p.K50N | Q9Y530 | protein_coding | tolerated(0.24) | possibly_damaging(0.779) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | rs529411165 | c.409N>A | p.Glu137Lys | p.E137K | Q9Y530 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| OARD1 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q9Y530 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |