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Gene: NXPE4 |
Gene summary for NXPE4 |
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Gene information | Species | Human | Gene symbol | NXPE4 | Gene ID | 54827 |
Gene name | neurexophilin and PC-esterase domain family member 4 | |
Gene Alias | C11orf33 | |
Cytomap | 11q23.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6UWF7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54827 | NXPE4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.49e-24 | -7.92e-01 | 0.0155 |
54827 | NXPE4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.56e-03 | -4.96e-01 | -0.1808 |
54827 | NXPE4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.94e-03 | -8.01e-01 | 0.0216 |
54827 | NXPE4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.92e-06 | -6.55e-01 | -0.1207 |
54827 | NXPE4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.42e-05 | -4.07e-01 | -0.1464 |
54827 | NXPE4 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.35e-05 | -4.43e-01 | -0.1001 |
54827 | NXPE4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.15e-06 | -5.36e-01 | -0.059 |
54827 | NXPE4 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.57e-16 | -7.14e-01 | 0.096 |
54827 | NXPE4 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.93e-04 | -8.68e-01 | 0.0451 |
54827 | NXPE4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.51e-08 | -6.85e-01 | 0.0338 |
54827 | NXPE4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-19 | -6.48e-01 | 0.0674 |
54827 | NXPE4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.44e-03 | -6.67e-01 | 0.0112 |
54827 | NXPE4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.30e-41 | -8.34e-01 | 0.294 |
54827 | NXPE4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.59e-11 | -7.81e-01 | 0.281 |
54827 | NXPE4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.92e-46 | -8.64e-01 | 0.3859 |
54827 | NXPE4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.13e-08 | -7.88e-01 | 0.2585 |
54827 | NXPE4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.11e-46 | -8.68e-01 | 0.3005 |
54827 | NXPE4 | F007 | Human | Colorectum | FAP | 1.02e-02 | -3.33e-01 | 0.1176 |
54827 | NXPE4 | A001-C-207 | Human | Colorectum | FAP | 6.51e-13 | -5.99e-01 | 0.1278 |
54827 | NXPE4 | A015-C-203 | Human | Colorectum | FAP | 9.55e-30 | -5.20e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXPE4 | SNV | Missense_Mutation | c.229G>C | p.Glu77Gln | p.E77Q | Q6UWF7 | protein_coding | tolerated(0.06) | possibly_damaging(0.616) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NXPE4 | SNV | Missense_Mutation | novel | c.755N>A | p.Ala252Asp | p.A252D | Q6UWF7 | protein_coding | tolerated(0.37) | benign(0.009) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NXPE4 | SNV | Missense_Mutation | novel | c.1534N>C | p.Asp512His | p.D512H | Q6UWF7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
NXPE4 | SNV | Missense_Mutation | c.482N>T | p.Gly161Val | p.G161V | Q6UWF7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NXPE4 | SNV | Missense_Mutation | c.1306N>T | p.Gly436Cys | p.G436C | Q6UWF7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NXPE4 | SNV | Missense_Mutation | novel | c.241C>A | p.Gln81Lys | p.Q81K | Q6UWF7 | protein_coding | tolerated(0.14) | benign(0.029) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE4 | SNV | Missense_Mutation | c.863T>G | p.Phe288Cys | p.F288C | Q6UWF7 | protein_coding | deleterious(0.02) | probably_damaging(0.91) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NXPE4 | SNV | Missense_Mutation | novel | c.611N>C | p.Phe204Ser | p.F204S | Q6UWF7 | protein_coding | deleterious(0.03) | probably_damaging(0.927) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NXPE4 | SNV | Missense_Mutation | c.409N>G | p.Phe137Val | p.F137V | Q6UWF7 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NXPE4 | insertion | Frame_Shift_Ins | novel | c.765_766insG | p.His256AlafsTer5 | p.H256Afs*5 | Q6UWF7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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