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Gene: NUTF2 |
Gene summary for NUTF2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NUTF2 | Gene ID | 10204 |
| Gene name | nuclear transport factor 2 | |
| Gene Alias | NTF-2 | |
| Cytomap | 16q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A0A024R6Y2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10204 | NUTF2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.78e-07 | 2.78e-01 | -0.1808 |
| 10204 | NUTF2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.33e-09 | 4.82e-01 | -0.0811 |
| 10204 | NUTF2 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.10e-04 | 2.58e-01 | -0.1088 |
| 10204 | NUTF2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.66e-12 | 3.65e-01 | -0.1954 |
| 10204 | NUTF2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.52e-07 | 7.20e-01 | -0.2602 |
| 10204 | NUTF2 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.02e-04 | 2.83e-01 | -0.1464 |
| 10204 | NUTF2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.61e-05 | 2.54e-01 | -0.1001 |
| 10204 | NUTF2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.86e-08 | 3.99e-01 | -0.059 |
| 10204 | NUTF2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.69e-13 | 4.69e-01 | 0.096 |
| 10204 | NUTF2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.52e-02 | 2.81e-01 | -0.0177 |
| 10204 | NUTF2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.87e-02 | 2.31e-01 | 0.0338 |
| 10204 | NUTF2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.31e-04 | 2.22e-01 | 0.0674 |
| 10204 | NUTF2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.49e-05 | 3.85e-01 | 0.0588 |
| 10204 | NUTF2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.19e-11 | 3.63e-01 | 0.294 |
| 10204 | NUTF2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.21e-05 | 8.72e-01 | 0.3487 |
| 10204 | NUTF2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.41e-14 | 6.50e-01 | 0.281 |
| 10204 | NUTF2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.52e-23 | 7.05e-01 | 0.3859 |
| 10204 | NUTF2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.42e-04 | 3.45e-01 | 0.2585 |
| 10204 | NUTF2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.05e-06 | 2.86e-01 | 0.3005 |
| 10204 | NUTF2 | LZE2D | Human | Esophagus | HGIN | 5.37e-04 | 2.02e-01 | 0.0642 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
| GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
| GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
| GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
| GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
| GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
| GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
| GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
| GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
| GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
| GO:0046822 | Colorectum | AD | regulation of nucleocytoplasmic transport | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
| GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
| GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
| GO:0046824 | Colorectum | AD | positive regulation of nucleocytoplasmic transport | 27/3918 | 62/18723 | 4.91e-05 | 8.43e-04 | 27 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NUTF2 | SNV | Missense_Mutation | c.209C>T | p.Ala70Val | p.A70V | P61970 | protein_coding | tolerated(0.26) | benign(0.048) | TCGA-AR-A1AV-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
| NUTF2 | insertion | In_Frame_Ins | novel | c.172-1_172insGTGCGATTTCGGCTCGCTACAAACCGCCGCCTCCTGGGTTCA | p.Ser57_Ser58insValArgPheArgLeuAlaThrAsnArgArgLeuLeuGlySer | p.S57_S58insVRFRLATNRRLLGS | P61970 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| NUTF2 | deletion | Frame_Shift_Del | novel | c.267delT | p.Lys90ArgfsTer16 | p.K90Rfs*16 | P61970 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| NUTF2 | SNV | Missense_Mutation | c.110C>T | p.Ser37Leu | p.S37L | P61970 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| NUTF2 | SNV | Missense_Mutation | novel | c.27N>C | p.Gln9His | p.Q9H | P61970 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| NUTF2 | SNV | Missense_Mutation | novel | c.119N>T | p.Thr40Met | p.T40M | P61970 | protein_coding | deleterious(0.03) | possibly_damaging(0.596) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| NUTF2 | SNV | Missense_Mutation | c.209C>T | p.Ala70Val | p.A70V | P61970 | protein_coding | tolerated(0.26) | benign(0.048) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| NUTF2 | SNV | Missense_Mutation | rs780123868 | c.107C>T | p.Ala36Val | p.A36V | P61970 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NUTF2 | SNV | Missense_Mutation | novel | c.73N>T | p.Asp25Tyr | p.D25Y | P61970 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NUTF2 | SNV | Missense_Mutation | novel | c.263A>T | p.Gln88Leu | p.Q88L | P61970 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DD-AACZ-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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