Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: NUP93

Gene summary for NUP93

Gene summary.

Gene information	Species	Human
	Gene symbol	NUP93
	Gene ID	9688
	Gene name	nucleoporin 93
	Gene Alias	NIC96
	Cytomap	16q13
	Gene Type	protein-coding
	GO ID	GO:0006403
	UniProtAcc	Q8N1F7

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
9688	NUP93	CCI_2	Human	Cervix	CC	9.20e-08	7.17e-01	0.5249
9688	NUP93	CCI_3	Human	Cervix	CC	9.99e-03	5.30e-01	0.516
9688	NUP93	LZE2T	Human	Esophagus	ESCC	1.10e-04	5.04e-01	0.082
9688	NUP93	LZE4T	Human	Esophagus	ESCC	4.29e-04	1.14e-01	0.0811
9688	NUP93	LZE20T	Human	Esophagus	ESCC	3.27e-02	1.28e-01	0.0662
9688	NUP93	LZE22T	Human	Esophagus	ESCC	4.26e-02	1.64e-01	0.068
9688	NUP93	LZE24T	Human	Esophagus	ESCC	7.81e-10	1.81e-01	0.0596
9688	NUP93	LZE21T	Human	Esophagus	ESCC	8.50e-05	2.42e-01	0.0655
9688	NUP93	LZE6T	Human	Esophagus	ESCC	2.25e-03	1.77e-01	0.0845
9688	NUP93	P1T-E	Human	Esophagus	ESCC	2.56e-04	3.57e-01	0.0875
9688	NUP93	P2T-E	Human	Esophagus	ESCC	2.76e-17	2.18e-01	0.1177
9688	NUP93	P4T-E	Human	Esophagus	ESCC	3.19e-15	4.12e-01	0.1323
9688	NUP93	P5T-E	Human	Esophagus	ESCC	1.95e-09	2.65e-01	0.1327
9688	NUP93	P8T-E	Human	Esophagus	ESCC	2.40e-10	1.85e-01	0.0889
9688	NUP93	P9T-E	Human	Esophagus	ESCC	1.40e-02	8.43e-02	0.1131
9688	NUP93	P10T-E	Human	Esophagus	ESCC	1.31e-07	1.52e-01	0.116
9688	NUP93	P11T-E	Human	Esophagus	ESCC	1.32e-07	2.64e-01	0.1426
9688	NUP93	P12T-E	Human	Esophagus	ESCC	1.96e-14	3.13e-01	0.1122
9688	NUP93	P15T-E	Human	Esophagus	ESCC	3.41e-10	2.47e-01	0.1149
9688	NUP93	P16T-E	Human	Esophagus	ESCC	1.12e-13	1.86e-01	0.1153

Page: 1 2 3 4 5

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00725949	Cervix	CC	establishment of protein localization to organelle	99/2311	422/18723	1.23e-10	2.11e-08	99
GO:00069139	Cervix	CC	nucleocytoplasmic transport	71/2311	301/18723	4.04e-08	2.54e-06	71
GO:00511699	Cervix	CC	nuclear transport	71/2311	301/18723	4.04e-08	2.54e-06	71
GO:00345048	Cervix	CC	protein localization to nucleus	68/2311	290/18723	9.91e-08	5.25e-06	68
GO:00170388	Cervix	CC	protein import	48/2311	206/18723	8.62e-06	1.98e-04	48
GO:00511689	Cervix	CC	nuclear export	38/2311	154/18723	1.86e-05	3.46e-04	38
GO:00511707	Cervix	CC	import into nucleus	38/2311	159/18723	3.98e-05	6.18e-04	38
GO:00512368	Cervix	CC	establishment of RNA localization	39/2311	166/18723	4.76e-05	7.25e-04	39
GO:00066067	Cervix	CC	protein import into nucleus	37/2311	155/18723	5.13e-05	7.71e-04	37
GO:00506578	Cervix	CC	nucleic acid transport	38/2311	163/18723	7.06e-05	9.85e-04	38
GO:00506588	Cervix	CC	RNA transport	38/2311	163/18723	7.06e-05	9.85e-04	38
GO:000640310	Cervix	CC	RNA localization	43/2311	201/18723	2.00e-04	2.29e-03	43
GO:00510284	Cervix	CC	mRNA transport	31/2311	130/18723	2.05e-04	2.33e-03	31
GO:00071786	Cervix	CC	transmembrane receptor protein serine/threonine kinase signaling pathway	67/2311	355/18723	2.39e-04	2.67e-03	67
GO:00469312	Cervix	CC	pore complex assembly	9/2311	20/18723	3.06e-04	3.27e-03	9
GO:00159318	Cervix	CC	nucleobase-containing compound transport	43/2311	222/18723	1.72e-03	1.30e-02	43
GO:00069991	Cervix	CC	nuclear pore organization	6/2311	14/18723	4.36e-03	2.67e-02	6
GO:00714262	Cervix	CC	ribonucleoprotein complex export from nucleus	18/2311	76/18723	4.45e-03	2.71e-02	18
GO:00711662	Cervix	CC	ribonucleoprotein complex localization	18/2311	77/18723	5.15e-03	3.03e-02	18
GO:00064054	Cervix	CC	RNA export from nucleus	19/2311	84/18723	6.02e-03	3.43e-02	19

Page: 1 2 3 4 5

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0501418	Cervix	CC	Amyotrophic lateral sclerosis	103/1267	364/8465	1.79e-11	4.47e-10	2.64e-10	103
hsa0501419	Cervix	CC	Amyotrophic lateral sclerosis	103/1267	364/8465	1.79e-11	4.47e-10	2.64e-10	103
hsa05014210	Esophagus	ESCC	Amyotrophic lateral sclerosis	266/4205	364/8465	1.31e-20	2.20e-18	1.13e-18	266
hsa0301321	Esophagus	ESCC	Nucleocytoplasmic transport	89/4205	108/8465	1.20e-12	2.37e-11	1.21e-11	89
hsa0501438	Esophagus	ESCC	Amyotrophic lateral sclerosis	266/4205	364/8465	1.31e-20	2.20e-18	1.13e-18	266
hsa0301331	Esophagus	ESCC	Nucleocytoplasmic transport	89/4205	108/8465	1.20e-12	2.37e-11	1.21e-11	89
hsa0501428	Oral cavity	OSCC	Amyotrophic lateral sclerosis	246/3704	364/8465	6.65e-21	1.11e-18	5.67e-19	246
hsa030136	Oral cavity	OSCC	Nucleocytoplasmic transport	82/3704	108/8465	7.93e-12	1.33e-10	6.77e-11	82
hsa05014112	Oral cavity	OSCC	Amyotrophic lateral sclerosis	246/3704	364/8465	6.65e-21	1.11e-18	5.67e-19	246
hsa0301311	Oral cavity	OSCC	Nucleocytoplasmic transport	82/3704	108/8465	7.93e-12	1.33e-10	6.77e-11	82

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

NUP93

SNV

Missense_Mutation

rs371707121

c.1609N>T

p.Arg537Trp

p.R537W

Q8N1F7

protein_coding

deleterious(0)

probably_damaging(0.991)

TCGA-A7-A6VV-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cyclophosphamide

NUP93

SNV

Missense_Mutation

rs528073782

c.40G>A

p.Glu14Lys

p.E14K

Q8N1F7

protein_coding

deleterious(0.05)

benign(0.013)

TCGA-BH-A209-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

NUP93

SNV

Missense_Mutation

rs528073782

c.40N>A

p.Glu14Lys

p.E14K

Q8N1F7

protein_coding

deleterious(0.05)

benign(0.013)

TCGA-BH-A2L8-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

NUP93

SNV

Missense_Mutation

rs528073782

c.40G>A

p.Glu14Lys

p.E14K

Q8N1F7

protein_coding

deleterious(0.05)

benign(0.013)

TCGA-E2-A10C-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

NUP93

SNV

Missense_Mutation

rs528073782

c.40G>A

p.Glu14Lys

p.E14K

Q8N1F7

protein_coding

deleterious(0.05)

benign(0.013)

TCGA-E9-A1NC-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

NUP93

insertion

Nonsense_Mutation

novel

c.195_196insGCAACAGAGCAAGACCCTGTCTGAAAATAAAATAAAATAGAC

p.Gly65_Ser66insAlaThrGluGlnAspProValTerLysTerAsnLysIleAsp

p.G65_S66insATEQDPV*K*NKID

Q8N1F7

protein_coding

TCGA-A8-A08H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

NUP93

deletion

Frame_Shift_Del

novel

c.1390delC

p.Gln464LysfsTer5

p.Q464Kfs*5

Q8N1F7

protein_coding

TCGA-D8-A27V-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

tamoxiphen

NUP93

SNV

Missense_Mutation

novel

c.773C>T

p.Ala258Val

p.A258V

Q8N1F7

protein_coding

deleterious(0.01)

possibly_damaging(0.78)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

NUP93

SNV

Missense_Mutation

novel

c.1600C>A

p.Leu534Met

p.L534M

Q8N1F7

protein_coding

tolerated(0.25)

benign(0.123)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

NUP93

SNV

Missense_Mutation

rs145578512

c.1000N>A

p.Ala334Thr

p.A334T

Q8N1F7

protein_coding

deleterious(0.05)

probably_damaging(0.94)

TCGA-C5-A1MH-01

Cervix

cervical & endocervical cancer

Female

>=65

III/IV

Chemotherapy

cisplatin

Page: 1 2 3 4 5 6 7 8 9

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1