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Gene: NUBPL |
Gene summary for NUBPL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NUBPL | Gene ID | 80224 |
| Gene name | nucleotide binding protein like | |
| Gene Alias | C14orf127 | |
| Cytomap | 14q12 | |
| Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | B4DWB0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 80224 | NUBPL | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.18e-08 | -4.61e-01 | 0.0155 |
| 80224 | NUBPL | HTA11_696_2000001011 | Human | Colorectum | AD | 1.71e-04 | -3.68e-01 | -0.1464 |
| 80224 | NUBPL | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.36e-03 | -6.33e-01 | -0.2061 |
| 80224 | NUBPL | HTA11_866_3004761011 | Human | Colorectum | AD | 4.80e-03 | -3.80e-01 | 0.096 |
| 80224 | NUBPL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.54e-04 | -3.40e-01 | 0.3005 |
| 80224 | NUBPL | A002-C-010 | Human | Colorectum | FAP | 3.61e-02 | 6.87e-02 | 0.242 |
| 80224 | NUBPL | A015-C-203 | Human | Colorectum | FAP | 1.12e-17 | -1.41e-01 | -0.1294 |
| 80224 | NUBPL | A015-C-204 | Human | Colorectum | FAP | 1.23e-03 | -1.23e-01 | -0.0228 |
| 80224 | NUBPL | A014-C-040 | Human | Colorectum | FAP | 2.54e-03 | -7.82e-02 | -0.1184 |
| 80224 | NUBPL | A002-C-201 | Human | Colorectum | FAP | 7.49e-13 | -3.27e-01 | 0.0324 |
| 80224 | NUBPL | A002-C-203 | Human | Colorectum | FAP | 1.21e-02 | 8.64e-02 | 0.2786 |
| 80224 | NUBPL | A001-C-119 | Human | Colorectum | FAP | 2.59e-08 | -3.81e-01 | -0.1557 |
| 80224 | NUBPL | A001-C-108 | Human | Colorectum | FAP | 2.02e-08 | -1.51e-01 | -0.0272 |
| 80224 | NUBPL | A002-C-205 | Human | Colorectum | FAP | 4.39e-22 | -4.62e-01 | -0.1236 |
| 80224 | NUBPL | A015-C-005 | Human | Colorectum | FAP | 6.30e-03 | -1.60e-01 | -0.0336 |
| 80224 | NUBPL | A015-C-006 | Human | Colorectum | FAP | 4.62e-13 | -7.57e-02 | -0.0994 |
| 80224 | NUBPL | A015-C-106 | Human | Colorectum | FAP | 4.86e-08 | -7.27e-02 | -0.0511 |
| 80224 | NUBPL | A002-C-114 | Human | Colorectum | FAP | 3.46e-15 | -1.97e-01 | -0.1561 |
| 80224 | NUBPL | A015-C-104 | Human | Colorectum | FAP | 8.45e-19 | -2.60e-01 | -0.1899 |
| 80224 | NUBPL | A001-C-014 | Human | Colorectum | FAP | 4.07e-08 | -1.27e-01 | 0.0135 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010257 | Colorectum | AD | NADH dehydrogenase complex assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
| GO:0032981 | Colorectum | AD | mitochondrial respiratory chain complex I assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
| GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:0070584 | Colorectum | AD | mitochondrion morphogenesis | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
| GO:00102572 | Colorectum | MSS | NADH dehydrogenase complex assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
| GO:00329812 | Colorectum | MSS | mitochondrial respiratory chain complex I assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
| GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
| GO:00705842 | Colorectum | MSS | mitochondrion morphogenesis | 12/3467 | 21/18723 | 8.83e-05 | 1.41e-03 | 12 |
| GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
| GO:00705843 | Colorectum | FAP | mitochondrion morphogenesis | 9/2622 | 21/18723 | 1.22e-03 | 1.14e-02 | 9 |
| GO:00705844 | Colorectum | CRC | mitochondrion morphogenesis | 8/2078 | 21/18723 | 1.22e-03 | 1.38e-02 | 8 |
| GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
| GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
| GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
| GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:00705848 | Esophagus | ESCC | mitochondrion morphogenesis | 18/8552 | 21/18723 | 1.81e-04 | 1.16e-03 | 18 |
| GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
| GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
| GO:00067904 | Liver | NAFLD | sulfur compound metabolic process | 58/1882 | 339/18723 | 3.79e-05 | 9.38e-04 | 58 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NUBPL | insertion | In_Frame_Ins | novel | c.676_677insACCATGTTA | p.Arg226delinsHisHisValSer | p.R226delinsHHVS | Q8TB37 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| NUBPL | insertion | In_Frame_Ins | novel | c.678_679insCAGGCTGGTCTTGAACTCCTGACCCCA | p.Arg226_Arg227insGlnAlaGlyLeuGluLeuLeuThrPro | p.R226_R227insQAGLELLTP | Q8TB37 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| NUBPL | SNV | Missense_Mutation | rs781341998 | c.488C>T | p.Ser163Leu | p.S163L | Q8TB37 | protein_coding | deleterious(0) | benign(0.232) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| NUBPL | SNV | Missense_Mutation | c.316N>A | p.Val106Met | p.V106M | Q8TB37 | protein_coding | deleterious(0) | possibly_damaging(0.549) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| NUBPL | SNV | Missense_Mutation | novel | c.717N>C | p.Met239Ile | p.M239I | Q8TB37 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| NUBPL | SNV | Missense_Mutation | c.613N>A | p.Val205Met | p.V205M | Q8TB37 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| NUBPL | SNV | Missense_Mutation | c.805N>C | p.Glu269Gln | p.E269Q | Q8TB37 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
| NUBPL | SNV | Missense_Mutation | novel | c.680G>C | p.Arg227Thr | p.R227T | Q8TB37 | protein_coding | deleterious(0) | benign(0.003) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| NUBPL | SNV | Missense_Mutation | rs749762773 | c.640N>A | p.Ala214Thr | p.A214T | Q8TB37 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A6-2680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NUBPL | SNV | Missense_Mutation | rs776389264 | c.281C>T | p.Ala94Val | p.A94V | Q8TB37 | protein_coding | tolerated(0.06) | benign(0.391) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 80224 | NUBPL | NA | iloperidone | ILOPERIDONE | 18521091 |
| Page: 1 |
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