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Gene: NR2C2AP |
Gene summary for NR2C2AP |
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Gene information | Species | Human | Gene symbol | NR2C2AP | Gene ID | 126382 |
Gene name | nuclear receptor 2C2 associated protein | |
Gene Alias | TRA16 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86WQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126382 | NR2C2AP | LZE4T | Human | Esophagus | ESCC | 2.87e-09 | 2.10e-01 | 0.0811 |
126382 | NR2C2AP | LZE7T | Human | Esophagus | ESCC | 7.80e-06 | 6.13e-01 | 0.0667 |
126382 | NR2C2AP | LZE8T | Human | Esophagus | ESCC | 2.18e-04 | 9.10e-02 | 0.067 |
126382 | NR2C2AP | LZE20T | Human | Esophagus | ESCC | 5.95e-03 | 3.22e-02 | 0.0662 |
126382 | NR2C2AP | LZE22T | Human | Esophagus | ESCC | 4.99e-04 | 3.67e-01 | 0.068 |
126382 | NR2C2AP | LZE24T | Human | Esophagus | ESCC | 3.38e-16 | 4.73e-01 | 0.0596 |
126382 | NR2C2AP | LZE6T | Human | Esophagus | ESCC | 1.23e-02 | 1.98e-01 | 0.0845 |
126382 | NR2C2AP | P1T-E | Human | Esophagus | ESCC | 1.20e-05 | 4.42e-01 | 0.0875 |
126382 | NR2C2AP | P2T-E | Human | Esophagus | ESCC | 8.62e-14 | 2.16e-01 | 0.1177 |
126382 | NR2C2AP | P4T-E | Human | Esophagus | ESCC | 5.89e-18 | 5.16e-01 | 0.1323 |
126382 | NR2C2AP | P5T-E | Human | Esophagus | ESCC | 1.65e-20 | 5.02e-01 | 0.1327 |
126382 | NR2C2AP | P8T-E | Human | Esophagus | ESCC | 2.58e-14 | 4.47e-01 | 0.0889 |
126382 | NR2C2AP | P9T-E | Human | Esophagus | ESCC | 6.63e-13 | 3.20e-01 | 0.1131 |
126382 | NR2C2AP | P10T-E | Human | Esophagus | ESCC | 1.30e-23 | 5.74e-01 | 0.116 |
126382 | NR2C2AP | P11T-E | Human | Esophagus | ESCC | 1.28e-08 | 3.55e-01 | 0.1426 |
126382 | NR2C2AP | P12T-E | Human | Esophagus | ESCC | 2.45e-19 | 3.27e-01 | 0.1122 |
126382 | NR2C2AP | P15T-E | Human | Esophagus | ESCC | 1.11e-12 | 2.58e-01 | 0.1149 |
126382 | NR2C2AP | P16T-E | Human | Esophagus | ESCC | 1.01e-10 | 1.69e-01 | 0.1153 |
126382 | NR2C2AP | P17T-E | Human | Esophagus | ESCC | 3.70e-05 | 3.71e-01 | 0.1278 |
126382 | NR2C2AP | P19T-E | Human | Esophagus | ESCC | 5.10e-05 | 6.69e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR2C2AP | SNV | Missense_Mutation | rs776177267 | c.218N>A | p.Arg73His | p.R73H | Q86WQ0 | protein_coding | tolerated(0.18) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NR2C2AP | SNV | Missense_Mutation | rs773638257 | c.67N>G | p.Arg23Gly | p.R23G | Q86WQ0 | protein_coding | deleterious(0) | possibly_damaging(0.498) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NR2C2AP | SNV | Missense_Mutation | c.59N>A | p.Arg20His | p.R20H | Q86WQ0 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-DR-A0ZL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NR2C2AP | SNV | Missense_Mutation | c.413N>C | p.Lys138Thr | p.K138T | Q86WQ0 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
NR2C2AP | SNV | Missense_Mutation | novel | c.88C>A | p.Leu30Ile | p.L30I | Q86WQ0 | protein_coding | deleterious(0.04) | probably_damaging(0.976) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NR2C2AP | SNV | Missense_Mutation | novel | c.57T>G | p.Asn19Lys | p.N19K | Q86WQ0 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AJ-A2QM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
NR2C2AP | SNV | Missense_Mutation | novel | c.354G>T | p.Glu118Asp | p.E118D | Q86WQ0 | protein_coding | tolerated(0.11) | possibly_damaging(0.498) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NR2C2AP | SNV | Missense_Mutation | novel | c.119N>T | p.Asn40Ile | p.N40I | Q86WQ0 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
NR2C2AP | SNV | Missense_Mutation | novel | c.294N>A | p.Asn98Lys | p.N98K | Q86WQ0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
NR2C2AP | SNV | Missense_Mutation | novel | c.387C>G | p.Ile129Met | p.I129M | Q86WQ0 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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