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Gene: NPTXR |
Gene summary for NPTXR |
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Gene information | Species | Human | Gene symbol | NPTXR | Gene ID | 23467 |
Gene name | neuronal pentraxin receptor | |
Gene Alias | NPR | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O95502 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23467 | NPTXR | HCC1 | Human | Liver | HCC | 2.10e-06 | 7.39e-01 | 0.5336 |
23467 | NPTXR | HCC2 | Human | Liver | HCC | 2.13e-19 | 1.47e+00 | 0.5341 |
23467 | NPTXR | HCC5 | Human | Liver | HCC | 7.01e-20 | 1.11e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPTXR | SNV | Missense_Mutation | c.1454N>A | p.Gly485Asp | p.G485D | O95502 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NPTXR | insertion | Nonsense_Mutation | novel | c.933_934insAACTCTTGTCTCTTAGGGTTGTAGTGAGAAGT | p.Ala312AsnfsTer8 | p.A312Nfs*8 | O95502 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
NPTXR | deletion | Frame_Shift_Del | novel | c.1036delG | p.Ala346ProfsTer7 | p.A346Pfs*7 | O95502 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
NPTXR | SNV | Missense_Mutation | rs200083748 | c.1030G>A | p.Gly344Arg | p.G344R | O95502 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NPTXR | SNV | Missense_Mutation | novel | c.1027C>T | p.Pro343Ser | p.P343S | O95502 | protein_coding | deleterious(0.01) | benign(0.395) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NPTXR | SNV | Missense_Mutation | rs200507552 | c.781N>T | p.Arg261Cys | p.R261C | O95502 | protein_coding | deleterious(0.01) | possibly_damaging(0.594) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NPTXR | SNV | Missense_Mutation | novel | c.1312G>T | p.Ala438Ser | p.A438S | O95502 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NPTXR | SNV | Missense_Mutation | novel | c.827G>C | p.Gly276Ala | p.G276A | O95502 | protein_coding | tolerated(0.19) | possibly_damaging(0.579) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
NPTXR | SNV | Missense_Mutation | novel | c.885N>T | p.Lys295Asn | p.K295N | O95502 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPTXR | SNV | Missense_Mutation | novel | c.1445N>T | p.Ala482Val | p.A482V | O95502 | protein_coding | tolerated(1) | benign(0.015) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23467 | NPTXR | NA | NNZ-2566 |
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