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Gene: NPM2 |
Gene summary for NPM2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NPM2 | Gene ID | 10361 |
| Gene name | nucleophosmin/nucleoplasmin 2 | |
| Gene Alias | NPM2 | |
| Cytomap | 8p21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86SE8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10361 | NPM2 | LZE24T | Human | Esophagus | ESCC | 1.24e-25 | 6.38e-01 | 0.0596 |
| 10361 | NPM2 | P8T-E | Human | Esophagus | ESCC | 2.56e-09 | 2.46e-01 | 0.0889 |
| 10361 | NPM2 | P9T-E | Human | Esophagus | ESCC | 1.09e-13 | 2.75e-01 | 0.1131 |
| 10361 | NPM2 | P10T-E | Human | Esophagus | ESCC | 2.37e-13 | 1.75e-01 | 0.116 |
| 10361 | NPM2 | P12T-E | Human | Esophagus | ESCC | 3.44e-02 | 1.11e-01 | 0.1122 |
| 10361 | NPM2 | P16T-E | Human | Esophagus | ESCC | 3.94e-02 | 5.65e-02 | 0.1153 |
| 10361 | NPM2 | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 8.65e-02 | 0.1124 |
| 10361 | NPM2 | P23T-E | Human | Esophagus | ESCC | 3.36e-03 | 9.72e-02 | 0.108 |
| 10361 | NPM2 | P26T-E | Human | Esophagus | ESCC | 3.42e-09 | 2.08e-01 | 0.1276 |
| 10361 | NPM2 | P27T-E | Human | Esophagus | ESCC | 5.59e-07 | 9.20e-02 | 0.1055 |
| 10361 | NPM2 | P28T-E | Human | Esophagus | ESCC | 5.51e-04 | 1.46e-01 | 0.1149 |
| 10361 | NPM2 | P30T-E | Human | Esophagus | ESCC | 4.84e-02 | 1.26e-01 | 0.137 |
| 10361 | NPM2 | P31T-E | Human | Esophagus | ESCC | 1.09e-02 | 1.00e-01 | 0.1251 |
| 10361 | NPM2 | P36T-E | Human | Esophagus | ESCC | 5.72e-04 | 1.17e-01 | 0.1187 |
| 10361 | NPM2 | P48T-E | Human | Esophagus | ESCC | 3.09e-10 | 8.87e-02 | 0.0959 |
| 10361 | NPM2 | P61T-E | Human | Esophagus | ESCC | 3.11e-12 | 2.70e-01 | 0.099 |
| 10361 | NPM2 | P74T-E | Human | Esophagus | ESCC | 4.95e-14 | 3.27e-01 | 0.1479 |
| 10361 | NPM2 | P75T-E | Human | Esophagus | ESCC | 1.50e-05 | 1.16e-01 | 0.1125 |
| 10361 | NPM2 | P76T-E | Human | Esophagus | ESCC | 5.56e-08 | 1.98e-01 | 0.1207 |
| 10361 | NPM2 | P89T-E | Human | Esophagus | ESCC | 4.86e-05 | 3.24e-01 | 0.1752 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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