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Gene: NPIPA2 |
Gene summary for NPIPA2 |
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Gene information | Species | Human | Gene symbol | NPIPA2 | Gene ID | 642799 |
Gene name | nuclear pore complex interacting protein family member A2 | |
Gene Alias | NPIP | |
Cytomap | 16p13.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A0B4J2F6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
642799 | NPIPA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.47e-05 | 1.94e-01 | 0.0155 |
642799 | NPIPA2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.18e-10 | 4.43e-01 | -0.1808 |
642799 | NPIPA2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.40e-12 | 4.75e-01 | -0.0811 |
642799 | NPIPA2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.54e-16 | 5.11e-01 | -0.1088 |
642799 | NPIPA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.61e-42 | 7.27e-01 | -0.1954 |
642799 | NPIPA2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.39e-08 | 3.35e-01 | -0.1207 |
642799 | NPIPA2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.63e-15 | 4.72e-01 | -0.1526 |
642799 | NPIPA2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.16e-33 | 6.84e-01 | -0.1464 |
642799 | NPIPA2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.80e-32 | 5.70e-01 | -0.1001 |
642799 | NPIPA2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.92e-16 | 4.69e-01 | -0.059 |
642799 | NPIPA2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.67e-18 | 8.03e-01 | -0.2061 |
642799 | NPIPA2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.06e-04 | 4.11e-01 | -0.1462 |
642799 | NPIPA2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.28e-11 | 5.01e-01 | -0.0842 |
642799 | NPIPA2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.34e-07 | 4.47e-01 | -0.0179 |
642799 | NPIPA2 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.51e-11 | 3.10e-01 | 0.096 |
642799 | NPIPA2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.57e-04 | 3.79e-01 | 0.0131 |
642799 | NPIPA2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.04e-04 | 3.13e-01 | -0.0177 |
642799 | NPIPA2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.76e-08 | 3.15e-01 | 0.0338 |
642799 | NPIPA2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.56e-07 | 1.44e-01 | 0.0674 |
642799 | NPIPA2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.43e-05 | 3.39e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPIPA2 | SNV | Missense_Mutation | rs748143363 | c.968N>T | p.Ser323Leu | p.S323L | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
NPIPA2 | SNV | Missense_Mutation | novel | c.865N>A | p.Pro289Thr | p.P289T | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.803) | TCGA-AA-3679-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | SD | |
NPIPA2 | SNV | Missense_Mutation | novel | c.989N>T | p.Thr330Ile | p.T330I | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.997) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
NPIPA2 | SNV | Missense_Mutation | novel | c.764C>A | p.Ser255Tyr | p.S255Y | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NPIPA2 | SNV | Missense_Mutation | novel | c.820N>A | p.Leu274Ile | p.L274I | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.567) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NPIPA2 | SNV | Missense_Mutation | novel | c.1046G>T | p.Arg349Ile | p.R349I | protein_coding | deleterious_low_confidence(0.01) | benign(0.246) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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