GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0008631 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to oxidative stress | 22/3918 | 45/18723 | 2.77e-05 | 5.24e-04 | 22 |
GO:1902175 | Colorectum | AD | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 16/3918 | 29/18723 | 5.32e-05 | 9.01e-04 | 16 |
GO:0036473 | Colorectum | AD | cell death in response to oxidative stress | 35/3918 | 95/18723 | 2.58e-04 | 3.24e-03 | 35 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0036295 | Colorectum | AD | cellular response to increased oxygen levels | 9/3918 | 14/18723 | 5.43e-04 | 5.79e-03 | 9 |
GO:1903201 | Colorectum | AD | regulation of oxidative stress-induced cell death | 28/3918 | 74/18723 | 6.29e-04 | 6.52e-03 | 28 |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:2001235 | Colorectum | AD | positive regulation of apoptotic signaling pathway | 42/3918 | 126/18723 | 7.85e-04 | 7.84e-03 | 42 |
GO:2001244 | Colorectum | AD | positive regulation of intrinsic apoptotic signaling pathway | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:0071453 | Colorectum | AD | cellular response to oxygen levels | 55/3918 | 177/18723 | 9.48e-04 | 8.96e-03 | 55 |
GO:1902882 | Colorectum | AD | regulation of response to oxidative stress | 34/3918 | 98/18723 | 1.09e-03 | 1.01e-02 | 34 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05208 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa05417 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa052081 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa054171 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa052082 | Colorectum | SER | Chemical carcinogenesis - reactive oxygen species | 103/1580 | 223/8465 | 1.60e-21 | 7.57e-20 | 5.50e-20 | 103 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa054182 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa054172 | Colorectum | SER | Lipid and atherosclerosis | 55/1580 | 215/8465 | 6.83e-03 | 3.77e-02 | 2.74e-02 | 55 |
hsa052083 | Colorectum | SER | Chemical carcinogenesis - reactive oxygen species | 103/1580 | 223/8465 | 1.60e-21 | 7.57e-20 | 5.50e-20 | 103 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa054183 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa054173 | Colorectum | SER | Lipid and atherosclerosis | 55/1580 | 215/8465 | 6.83e-03 | 3.77e-02 | 2.74e-02 | 55 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOX1 | SNV | Missense_Mutation | novel | c.802N>C | p.Glu268Gln | p.E268Q | Q9Y5S8 | protein_coding | tolerated(0.58) | benign(0.001) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOX1 | SNV | Missense_Mutation | rs769691003 | c.776N>A | p.Arg259His | p.R259H | Q9Y5S8 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AR-A1AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOX1 | SNV | Missense_Mutation | | c.1487T>G | p.Val496Gly | p.V496G | Q9Y5S8 | protein_coding | deleterious(0) | possibly_damaging(0.892) | TCGA-BH-A0BT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NOX1 | insertion | Nonsense_Mutation | rs761560592 | c.155_156insATTCTGAA | p.Cys52Ter | p.C52* | Q9Y5S8 | protein_coding | | | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NOX1 | insertion | Nonsense_Mutation | novel | c.155_156insAA | p.Cys52Ter | p.C52* | Q9Y5S8 | protein_coding | | | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NOX1 | insertion | Nonsense_Mutation | rs761560592 | c.155_156insATTCTGAA | p.Cys52Ter | p.C52* | Q9Y5S8 | protein_coding | | | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
NOX1 | SNV | Missense_Mutation | rs772834730 | c.869N>A | p.Arg290His | p.R290H | Q9Y5S8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NOX1 | SNV | Missense_Mutation | rs192653247 | c.263N>A | p.Arg88His | p.R88H | Q9Y5S8 | protein_coding | tolerated(0.34) | benign(0.112) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
NOX1 | SNV | Missense_Mutation | rs373860304 | c.218G>A | p.Arg73His | p.R73H | Q9Y5S8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NOX1 | SNV | Missense_Mutation | | c.1012C>T | p.His338Tyr | p.H338Y | Q9Y5S8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | inhibitor | 363894229 | | |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | | PHENOTHIAZINE | PHENOTHIAZINE | |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | | TCMDC-125505 | CHEMBL587104 | |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | inhibitor | 363894225 | | |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | inhibitor | 363894227 | | |
27035 | NOX1 | ION CHANNEL, ENZYME, TRANSPORTER, DRUGGABLE GENOME | inhibitor | 363894226 | | |