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Gene: NOSTRIN |
Gene summary for NOSTRIN |
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Gene information | Species | Human | Gene symbol | NOSTRIN | Gene ID | 115677 |
Gene name | nitric oxide synthase trafficking | |
Gene Alias | DaIP2 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IVI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115677 | NOSTRIN | GSM4909308 | Human | Breast | IDC | 1.20e-03 | 1.59e-01 | 0.158 |
115677 | NOSTRIN | GSM4909315 | Human | Breast | IDC | 1.78e-08 | 2.84e-01 | 0.21 |
115677 | NOSTRIN | M5 | Human | Breast | IDC | 3.86e-18 | 9.47e-01 | 0.1598 |
115677 | NOSTRIN | P3 | Human | Breast | IDC | 1.32e-05 | 4.39e-01 | 0.1542 |
115677 | NOSTRIN | DCIS2 | Human | Breast | DCIS | 4.86e-02 | -1.19e-02 | 0.0085 |
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Tissue | Expression Dynamics | Abbreviation |
Breast | ![]() | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ | ||
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOSTRIN | SNV | Missense_Mutation | novel | c.1454C>A | p.Ser485Tyr | p.S485Y | Q8IVI9 | protein_coding | tolerated(0.13) | benign(0.11) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
NOSTRIN | SNV | Missense_Mutation | c.1514N>G | p.Ser505Cys | p.S505C | Q8IVI9 | protein_coding | deleterious(0.03) | possibly_damaging(0.905) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NOSTRIN | SNV | Missense_Mutation | novel | c.304T>G | p.Tyr102Asp | p.Y102D | Q8IVI9 | protein_coding | tolerated(0.1) | benign(0.07) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
NOSTRIN | insertion | In_Frame_Ins | novel | c.1187_1188insTTT | p.Ala396_Lys397insLeu | p.A396_K397insL | Q8IVI9 | protein_coding | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NOSTRIN | insertion | Frame_Shift_Ins | novel | c.1189_1190insGCACCAGCACTTCTCAAATTTCATTAAGTGA | p.Lys397SerfsTer22 | p.K397Sfs*22 | Q8IVI9 | protein_coding | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NOSTRIN | insertion | In_Frame_Ins | novel | c.1648_1649insCAGCCAACACGCCAAACAATCAAAAACACC | p.Glu550delinsAlaAlaAsnThrProAsnAsnGlnLysHisGln | p.E550delinsAANTPNNQKHQ | Q8IVI9 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
NOSTRIN | SNV | Missense_Mutation | novel | c.1030N>A | p.Glu344Lys | p.E344K | Q8IVI9 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NOSTRIN | SNV | Missense_Mutation | rs773928664 | c.1064N>A | p.Arg355Gln | p.R355Q | Q8IVI9 | protein_coding | tolerated(0.3) | benign(0.067) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOSTRIN | SNV | Missense_Mutation | novel | c.1565N>G | p.Val522Gly | p.V522G | Q8IVI9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOSTRIN | deletion | Frame_Shift_Del | c.1386delN | p.Leu464Ter | p.L464* | Q8IVI9 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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