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Gene: NOC4L |
Gene summary for NOC4L |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NOC4L | Gene ID | 79050 |
| Gene name | nucleolar complex associated 4 homolog | |
| Gene Alias | NET49 | |
| Cytomap | 12q24.33 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BVI4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79050 | NOC4L | LZE4T | Human | Esophagus | ESCC | 4.53e-04 | 1.51e-01 | 0.0811 |
| 79050 | NOC4L | LZE7T | Human | Esophagus | ESCC | 3.01e-10 | 4.30e-01 | 0.0667 |
| 79050 | NOC4L | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 9.02e-02 | 0.067 |
| 79050 | NOC4L | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 1.62e-01 | 0.068 |
| 79050 | NOC4L | LZE24T | Human | Esophagus | ESCC | 1.47e-24 | 4.64e-01 | 0.0596 |
| 79050 | NOC4L | LZE21T | Human | Esophagus | ESCC | 1.78e-08 | 4.38e-01 | 0.0655 |
| 79050 | NOC4L | P1T-E | Human | Esophagus | ESCC | 1.98e-11 | 4.48e-01 | 0.0875 |
| 79050 | NOC4L | P2T-E | Human | Esophagus | ESCC | 5.67e-42 | 7.73e-01 | 0.1177 |
| 79050 | NOC4L | P4T-E | Human | Esophagus | ESCC | 1.32e-23 | 4.66e-01 | 0.1323 |
| 79050 | NOC4L | P5T-E | Human | Esophagus | ESCC | 2.34e-23 | 4.33e-01 | 0.1327 |
| 79050 | NOC4L | P8T-E | Human | Esophagus | ESCC | 1.95e-22 | 4.37e-01 | 0.0889 |
| 79050 | NOC4L | P9T-E | Human | Esophagus | ESCC | 1.09e-13 | 2.59e-01 | 0.1131 |
| 79050 | NOC4L | P10T-E | Human | Esophagus | ESCC | 7.08e-17 | 2.40e-01 | 0.116 |
| 79050 | NOC4L | P11T-E | Human | Esophagus | ESCC | 4.80e-15 | 5.07e-01 | 0.1426 |
| 79050 | NOC4L | P12T-E | Human | Esophagus | ESCC | 3.26e-15 | 3.19e-01 | 0.1122 |
| 79050 | NOC4L | P15T-E | Human | Esophagus | ESCC | 1.52e-21 | 3.94e-01 | 0.1149 |
| 79050 | NOC4L | P16T-E | Human | Esophagus | ESCC | 3.79e-13 | 2.88e-01 | 0.1153 |
| 79050 | NOC4L | P17T-E | Human | Esophagus | ESCC | 4.56e-20 | 6.02e-01 | 0.1278 |
| 79050 | NOC4L | P19T-E | Human | Esophagus | ESCC | 5.23e-14 | 6.42e-01 | 0.1662 |
| 79050 | NOC4L | P20T-E | Human | Esophagus | ESCC | 1.03e-28 | 4.47e-01 | 0.1124 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
| GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
| GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
| GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
| GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
| GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
| GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
| GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
| GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
| GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
| GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
| GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
| GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
| GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
| GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
| GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
| GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NOC4L | SNV | Missense_Mutation | novel | c.445C>T | p.Leu149Phe | p.L149F | Q9BVI4 | protein_coding | tolerated(0.13) | probably_damaging(0.947) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | rs766320330 | c.304N>T | p.Arg102Cys | p.R102C | Q9BVI4 | protein_coding | tolerated(0.24) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| NOC4L | SNV | Missense_Mutation | novel | c.1308N>T | p.Trp436Cys | p.W436C | Q9BVI4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | rs375866510 | c.361N>A | p.Ala121Thr | p.A121T | Q9BVI4 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | c.152N>A | p.Arg51His | p.R51H | Q9BVI4 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NOC4L | SNV | Missense_Mutation | rs375092329 | c.376N>A | p.Val126Met | p.V126M | Q9BVI4 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | rs141373941 | c.1363G>A | p.Val455Ile | p.V455I | Q9BVI4 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | rs577947175 | c.305N>A | p.Arg102His | p.R102H | Q9BVI4 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| NOC4L | SNV | Missense_Mutation | rs539569004 | c.1219N>T | p.Arg407Cys | p.R407C | Q9BVI4 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| NOC4L | SNV | Missense_Mutation | novel | c.1252T>C | p.Tyr418His | p.Y418H | Q9BVI4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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